Index	variant	cluster	cells	proposed_label	final_label	confidence	support	competing_explanation	rationale	reviewer	reviewer_role	reviewed_at	dictionary_sha256	cluster_membership_sha256	decision_version	decision_status	assessment_code	same_cell_evidence	library_evidence	qc_evidence	evidence_locator	assessor	assessor_role	assessed_at	proposal_confidence	proposal_rationale	review_disposition
0	complexity_high_removed	0	2939	VSMC	VSMC	supported	Acta2: 99.8% detected, mean 155 versus rest 105; Tagln: 99.5% detected, mean 96.2 versus rest 68.8; Myh11: 97.7% detected, mean 22.9 versus rest 13.7; Cnn1: 50.7% detected, mean 3.7 versus rest 1.86; Entpd1: 29.5% detected, mean 0.801 versus rest 0.623	Other programs remain visible: same-cell pericyte pair and contractile triple 7.2%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e35b07fe18394f5ff8bfbf086dec25d57590ee7ee59626b64224e324db3fe31a	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 250/2939 (8.5%); all four pericyte markers: 15/2939 (0.5%); Acta2/Tagln/Myh11: 2856/2939 (97.2%); Cnn1/Entpd1: 551/2939 (18.7%); Plp1/Cnp: 3/2939 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2939 (0.0%); Pecam1/Cdh5: 0/2939 (0.0%); Ptprc plus a listed subtype marker: 0/2939 (0.0%)	SS: n=2874; detection/mean Acta2 99.8%/155, Tagln 99.5%/95.9, Myh11 97.8%/22.7, Cnn1 50.9%/3.7, Entpd1 29.4%/0.79; pericyte pair 8.6%, contractile triple 97.3%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=49; detection/mean Acta2 100.0%/176, Tagln 100.0%/115, Myh11 89.8%/26, Cnn1 40.8%/3.06, Entpd1 32.7%/1.26; pericyte pair 4.1%, contractile triple 89.8%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=12 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/126, Tagln 100.0%/99.8, Myh11 100.0%/36, Cnn1 58.3%/7.14, Entpd1 33.3%/1.34; pericyte pair 8.3%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=4 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/149, Tagln 100.0%/50, Myh11 100.0%/27.6, Cnn1 25.0%/2.62, Entpd1 50.0%/1.07; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1813; median mitochondrial fraction 0.0605; predicted doublets 9/2939; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=complexity_high_removed, cluster=0; source annotation_evidence/markers_complexity_high_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.323649+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
1	complexity_high_removed	1	764	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 287 versus rest 106; Tagln: 100.0% detected, mean 228 versus rest 66.3; Myh11: 100.0% detected, mean 33.6 versus rest 14.4; Cnn1: 99.0% detected, mean 8.09 versus rest 1.9; Entpd1: 75.7% detected, mean 1.38 versus rest 0.619	Other programs remain visible: same-cell pericyte pair and contractile triple 5.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.3%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	95ee3d5969425fb051bc4a5327577ebf9085d29c39b4dae9c4ba7acfec294d3e	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 43/764 (5.6%); all four pericyte markers: 5/764 (0.7%); Acta2/Tagln/Myh11: 764/764 (100.0%); Cnn1/Entpd1: 575/764 (75.3%); Plp1/Cnp: 2/764 (0.3%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/764 (0.1%); Pecam1/Cdh5: 0/764 (0.0%); Ptprc plus a listed subtype marker: 0/764 (0.0%)	SS: n=28; detection/mean Acta2 100.0%/197, Tagln 100.0%/155, Myh11 100.0%/30.9, Cnn1 92.9%/8.46, Entpd1 35.7%/1.19; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=735; detection/mean Acta2 100.0%/290, Tagln 100.0%/230, Myh11 100.0%/33.7, Cnn1 99.2%/8.06, Entpd1 77.3%/1.39; pericyte pair 5.9%, contractile triple 100.0%, Schwann pair 0.3%, fibroblast pair 0.1% | D7: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/317, Tagln 100.0%/185, Myh11 100.0%/19.8, Cnn1 100.0%/19.8, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 3189; median mitochondrial fraction 0.0844; predicted doublets 0/764; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=complexity_high_removed, cluster=1; source annotation_evidence/markers_complexity_high_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.338934+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
2	complexity_high_removed	2	432	Schwann	Schwann	supported	Plp1: 96.8% detected, mean 23 versus rest 0.0545; Cnp: 88.9% detected, mean 13.4 versus rest 0.106	Other programs remain visible: same-cell pericyte pair and contractile triple 1.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 13.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e6f997da9513413875ba350696d03eb9becd30a955298bb06266857351585789	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 14/432 (3.2%); all four pericyte markers: 3/432 (0.7%); Acta2/Tagln/Myh11: 64/432 (14.8%); Cnn1/Entpd1: 10/432 (2.3%); Plp1/Cnp: 378/432 (87.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/432 (0.0%); Pecam1/Cdh5: 0/432 (0.0%); Ptprc plus a listed subtype marker: 0/432 (0.0%)	SS: n=121; detection/mean Plp1 95.0%/22, Cnp 90.1%/18.5; pericyte pair 1.7%, contractile triple 9.1%, Schwann pair 86.8%, fibroblast pair 0.0% | D3: n=215; detection/mean Plp1 97.7%/20.1, Cnp 87.0%/8.13; pericyte pair 5.6%, contractile triple 24.7%, Schwann pair 86.5%, fibroblast pair 0.0% | D7: n=35; detection/mean Plp1 94.3%/31.6, Cnp 85.7%/15.4; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 82.9%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1888; median mitochondrial fraction 0.0288; predicted doublets 4/432; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=complexity_high_removed, cluster=2; source annotation_evidence/markers_complexity_high_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.358153+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
3	complexity_high_removed	3	3201	VSMC	VSMC	supported	Acta2: 99.1% detected, mean 139 versus rest 108; Tagln: 98.3% detected, mean 70.3 versus rest 74.3; Myh11: 93.9% detected, mean 20.8 versus rest 14; Cnn1: 42.8% detected, mean 3.13 versus rest 1.95; Entpd1: 23.2% detected, mean 0.757 versus rest 0.63	Other programs remain visible: same-cell pericyte pair and contractile triple 10.1%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	708a6b2e129e03310e283f750a5906a8a1f590b488c51075b9468639a51f3e3e	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 410/3201 (12.8%); all four pericyte markers: 37/3201 (1.2%); Acta2/Tagln/Myh11: 2981/3201 (93.1%); Cnn1/Entpd1: 446/3201 (13.9%); Plp1/Cnp: 3/3201 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/3201 (0.0%); Pecam1/Cdh5: 0/3201 (0.0%); Ptprc plus a listed subtype marker: 0/3201 (0.0%)	SS: n=43; detection/mean Acta2 100.0%/99.6, Tagln 95.3%/57.7, Myh11 79.1%/14.2, Cnn1 18.6%/1.85, Entpd1 7.0%/0.378; pericyte pair 20.9%, contractile triple 76.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=13 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/153, Tagln 100.0%/109, Myh11 69.2%/26.7, Cnn1 30.8%/5.22, Entpd1 15.4%/0.673; pericyte pair 7.7%, contractile triple 69.2%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=1452; detection/mean Acta2 98.2%/127, Tagln 97.2%/62.3, Myh11 93.7%/19.6, Cnn1 41.3%/3.06, Entpd1 21.3%/0.723; pericyte pair 12.0%, contractile triple 92.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1693; detection/mean Acta2 99.8%/150, Tagln 99.2%/77.2, Myh11 94.7%/21.9, Cnn1 44.7%/3.21, Entpd1 25.3%/0.797; pericyte pair 13.3%, contractile triple 94.2%, Schwann pair 0.2%, fibroblast pair 0.0%	median detected genes 1487; median mitochondrial fraction 0.0633; predicted doublets 9/3201; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=complexity_high_removed, cluster=3; source annotation_evidence/markers_complexity_high_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.377910+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
4	complexity_high_removed	4	1365	pericyte	pericyte	supported	Kcnj8: 91.3% detected, mean 33.2 versus rest 3.47; Abcc9: 85.0% detected, mean 12.9 versus rest 2.95; Colec11: 92.5% detected, mean 24.2 versus rest 4.14; Vtn: 92.2% detected, mean 27 versus rest 3.96	Other programs remain visible: same-cell pericyte pair and contractile triple 9.5%; pericyte and fibroblast pairs 0.4%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	f7a52b9b5ab1ec2884b8ea70231ec51df84d50c8fe931e458406e4ab07b31888	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1323/1365 (96.9%); all four pericyte markers: 1000/1365 (73.3%); Acta2/Tagln/Myh11: 136/1365 (10.0%); Cnn1/Entpd1: 0/1365 (0.0%); Plp1/Cnp: 1/1365 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 7/1365 (0.5%); Pecam1/Cdh5: 0/1365 (0.0%); Ptprc plus a listed subtype marker: 0/1365 (0.0%)	SS: n=362; detection/mean Kcnj8 92.5%/26.9, Abcc9 85.6%/12.5, Colec11 95.0%/22.2, Vtn 95.3%/26.7; pericyte pair 98.6%, contractile triple 14.1%, Schwann pair 0.0%, fibroblast pair 0.6% | D3: n=59; detection/mean Kcnj8 76.3%/25.1, Abcc9 59.3%/13.9, Colec11 74.6%/19, Vtn 76.3%/19.6; pericyte pair 86.4%, contractile triple 10.2%, Schwann pair 0.0%, fibroblast pair 1.7% | D7: n=264; detection/mean Kcnj8 90.9%/35.8, Abcc9 84.1%/12, Colec11 93.6%/27.4, Vtn 92.4%/31.8; pericyte pair 96.6%, contractile triple 5.3%, Schwann pair 0.0%, fibroblast pair 0.8% | D42: n=680; detection/mean Kcnj8 92.1%/36.2, Abcc9 87.2%/13.3, Colec11 92.2%/24.4, Vtn 91.8%/25.9; pericyte pair 97.1%, contractile triple 9.6%, Schwann pair 0.1%, fibroblast pair 0.3%	median detected genes 1226; median mitochondrial fraction 0.031; predicted doublets 5/1365; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=complexity_high_removed, cluster=4; source annotation_evidence/markers_complexity_high_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.397586+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
5	complexity_high_removed	5	1900	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 147 versus rest 110; Tagln: 100.0% detected, mean 107 versus rest 69.3; Myh11: 99.6% detected, mean 18.7 versus rest 14.8; Cnn1: 51.3% detected, mean 2.01 versus rest 2.2; Entpd1: 54.1% detected, mean 1.12 versus rest 0.596	Other programs remain visible: same-cell pericyte pair and contractile triple 10.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	1060681934c53a8fc6d689c111cb5771ff6faff92f39b905bc2c5e6895d0889b	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 203/1900 (10.7%); all four pericyte markers: 23/1900 (1.2%); Acta2/Tagln/Myh11: 1892/1900 (99.6%); Cnn1/Entpd1: 627/1900 (33.0%); Plp1/Cnp: 1/1900 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/1900 (0.1%); Pecam1/Cdh5: 0/1900 (0.0%); Ptprc plus a listed subtype marker: 0/1900 (0.0%)	SS: n=17 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/147, Tagln 100.0%/87.1, Myh11 100.0%/25.8, Cnn1 76.5%/5.09, Entpd1 35.3%/0.707; pericyte pair 11.8%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1883; detection/mean Acta2 100.0%/148, Tagln 100.0%/107, Myh11 99.6%/18.6, Cnn1 51.1%/1.98, Entpd1 54.3%/1.12; pericyte pair 10.7%, contractile triple 99.6%, Schwann pair 0.1%, fibroblast pair 0.1% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2511; median mitochondrial fraction 0.0654; predicted doublets 0/1900; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=complexity_high_removed, cluster=5; source annotation_evidence/markers_complexity_high_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.408201+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
6	complexity_high_removed	6	3144	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 131 versus rest 110; Tagln: 99.1% detected, mean 91.8 versus rest 69.4; Myh11: 96.4% detected, mean 17.4 versus rest 14.8; Cnn1: 33.7% detected, mean 1.36 versus rest 2.36; Entpd1: 44.1% detected, mean 0.942 versus rest 0.589	Other programs remain visible: same-cell pericyte pair and contractile triple 26.3%; pericyte and fibroblast pairs 0.2%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	c373792053a0c9319a24bc6a6a2e3f9a8fee885372aa37cc977e49754119a8fd	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 905/3144 (28.8%); all four pericyte markers: 242/3144 (7.7%); Acta2/Tagln/Myh11: 3020/3144 (96.1%); Cnn1/Entpd1: 690/3144 (21.9%); Plp1/Cnp: 5/3144 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 6/3144 (0.2%); Pecam1/Cdh5: 0/3144 (0.0%); Ptprc plus a listed subtype marker: 0/3144 (0.0%)	SS: n=31; detection/mean Acta2 100.0%/91.4, Tagln 87.1%/54.9, Myh11 87.1%/14.1, Cnn1 32.3%/1.45, Entpd1 19.4%/0.334; pericyte pair 54.8%, contractile triple 80.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=3107; detection/mean Acta2 99.9%/131, Tagln 99.3%/92.3, Myh11 96.5%/17.5, Cnn1 33.8%/1.36, Entpd1 44.4%/0.948; pericyte pair 28.5%, contractile triple 96.3%, Schwann pair 0.2%, fibroblast pair 0.2% | D7: n=5 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/113, Tagln 60.0%/69.8, Myh11 100.0%/9.5, Cnn1 0.0%/0, Entpd1 20.0%/0.959; pericyte pair 60.0%, contractile triple 60.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/45.4, Tagln 100.0%/2.39, Myh11 100.0%/4.78, Cnn1 0.0%/0, Entpd1 0.0%/0; pericyte pair 100.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2380; median mitochondrial fraction 0.0635; predicted doublets 10/3144; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=complexity_high_removed, cluster=6; source annotation_evidence/markers_complexity_high_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.427918+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
7	complexity_high_removed	7	101	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 129 versus rest 114; Tagln: 100.0% detected, mean 94.3 versus rest 73.4; Myh11: 99.0% detected, mean 17.1 versus rest 15.3; Cnn1: 43.6% detected, mean 1.73 versus rest 2.18; Entpd1: 47.5% detected, mean 0.842 versus rest 0.652	Other programs remain visible: same-cell pericyte pair and contractile triple 21.8%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	41236ecc6a7306b98adb01747fcf37dee800d84db39a414034af32958a44a266	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 23/101 (22.8%); all four pericyte markers: 2/101 (2.0%); Acta2/Tagln/Myh11: 100/101 (99.0%); Cnn1/Entpd1: 25/101 (24.8%); Plp1/Cnp: 0/101 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/101 (0.0%); Pecam1/Cdh5: 0/101 (0.0%); Ptprc plus a listed subtype marker: 0/101 (0.0%)	SS: n=19 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/127, Tagln 100.0%/74.5, Myh11 100.0%/17.6, Cnn1 42.1%/2.15, Entpd1 31.6%/0.785; pericyte pair 5.3%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=76; detection/mean Acta2 100.0%/133, Tagln 100.0%/103, Myh11 100.0%/17, Cnn1 43.4%/1.57, Entpd1 53.9%/0.898; pericyte pair 26.3%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=2 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/94, Tagln 100.0%/50.5, Myh11 100.0%/17.9, Cnn1 100.0%/3.62, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=4 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/102, Tagln 100.0%/48.1, Myh11 75.0%/15.2, Cnn1 25.0%/1.88, Entpd1 25.0%/0.469; pericyte pair 50.0%, contractile triple 75.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2719; median mitochondrial fraction 0.053; predicted doublets 0/101; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=complexity_high_removed, cluster=7; source annotation_evidence/markers_complexity_high_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.447801+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
8	complexity_high_removed	8	1577	pericyte	pericyte	supported	Kcnj8: 92.6% detected, mean 24.1 versus rest 3.99; Abcc9: 96.8% detected, mean 21.5 versus rest 1.94; Colec11: 92.5% detected, mean 20.6 versus rest 4.23; Vtn: 92.3% detected, mean 17.7 versus rest 4.59	Other programs remain visible: same-cell pericyte pair and contractile triple 22.3%; pericyte and fibroblast pairs 1.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	29935e927a92ee89a702904406c3e534014dc8068e668fd1b276ad5806e78751	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1545/1577 (98.0%); all four pericyte markers: 1303/1577 (82.6%); Acta2/Tagln/Myh11: 361/1577 (22.9%); Cnn1/Entpd1: 0/1577 (0.0%); Plp1/Cnp: 2/1577 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 15/1577 (1.0%); Pecam1/Cdh5: 0/1577 (0.0%); Ptprc plus a listed subtype marker: 0/1577 (0.0%)	SS: n=17 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 76.5%/19.3, Abcc9 88.2%/14.4, Colec11 88.2%/19.2, Vtn 76.5%/17.2; pericyte pair 88.2%, contractile triple 17.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1560; detection/mean Kcnj8 92.8%/24.1, Abcc9 96.9%/21.6, Colec11 92.6%/20.6, Vtn 92.4%/17.7; pericyte pair 98.1%, contractile triple 22.9%, Schwann pair 0.1%, fibroblast pair 1.0% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 1744; median mitochondrial fraction 0.0444; predicted doublets 0/1577; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=complexity_high_removed, cluster=8; source annotation_evidence/markers_complexity_high_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.458279+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
9	complexity_high_removed	9	1425	pericyte	pericyte	supported	Kcnj8: 74.9% detected, mean 8.01 versus rest 5.64; Abcc9: 75.4% detected, mean 4.75 versus rest 3.65; Colec11: 84.6% detected, mean 16.7 versus rest 4.75; Vtn: 87.2% detected, mean 14.2 versus rest 5.04	Other programs remain visible: same-cell pericyte pair and contractile triple 46.9%; pericyte and fibroblast pairs 9.3%; Schwann pair and contractile triple 0.4%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	162b81ea8057a11432be3686bc97f199246bb1219607fa4cf5c874ddaa692053	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1307/1425 (91.7%); all four pericyte markers: 783/1425 (54.9%); Acta2/Tagln/Myh11: 737/1425 (51.7%); Cnn1/Entpd1: 29/1425 (2.0%); Plp1/Cnp: 7/1425 (0.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 160/1425 (11.2%); Pecam1/Cdh5: 0/1425 (0.0%); Ptprc plus a listed subtype marker: 0/1425 (0.0%)	SS: n=81; detection/mean Kcnj8 59.3%/5.89, Abcc9 46.9%/1.96, Colec11 81.5%/20.1, Vtn 75.3%/24.8; pericyte pair 79.0%, contractile triple 69.1%, Schwann pair 0.0%, fibroblast pair 14.8% | D3: n=596; detection/mean Kcnj8 74.8%/4.88, Abcc9 86.9%/5.1, Colec11 73.3%/6.05, Vtn 86.6%/6.52; pericyte pair 89.6%, contractile triple 69.3%, Schwann pair 0.8%, fibroblast pair 12.9% | D7: n=538; detection/mean Kcnj8 78.1%/11.3, Abcc9 74.5%/5.26, Colec11 93.3%/22.7, Vtn 87.0%/14.4; pericyte pair 94.4%, contractile triple 32.3%, Schwann pair 0.4%, fibroblast pair 11.0% | D42: n=210; detection/mean Kcnj8 73.3%/9.41, Abcc9 56.2%/3.53, Colec11 95.2%/30, Vtn 93.8%/31.1; pericyte pair 95.7%, contractile triple 44.8%, Schwann pair 0.0%, fibroblast pair 5.7%	median detected genes 2410; median mitochondrial fraction 0.0328; predicted doublets 4/1425; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=complexity_high_removed, cluster=9; source annotation_evidence/markers_complexity_high_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.477787+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
10	complexity_high_removed	10	249	fibroblast	fibroblast	supported	Pdgfra: 57.8% detected, mean 0.855 versus rest 0.0025; Lum: 96.0% detected, mean 25.9 versus rest 0.0578; Dcn: 99.6% detected, mean 71.1 versus rest 0.577; Cd34: 82.3% detected, mean 3.43 versus rest 0.0252	Other programs remain visible: same-cell pericyte pair and contractile triple 2.0%; pericyte and fibroblast pairs 6.8%; Schwann pair and contractile triple 1.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	abee59e3846960797fb0642344891c67335eac382d37b7cc4d38ce30f4232464	SCP002-A001	accepted_versioned_annotation_decision	F	at least two of Kcnj8/Abcc9/Colec11/Vtn: 17/249 (6.8%); all four pericyte markers: 3/249 (1.2%); Acta2/Tagln/Myh11: 45/249 (18.1%); Cnn1/Entpd1: 3/249 (1.2%); Plp1/Cnp: 3/249 (1.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 248/249 (99.6%); Pecam1/Cdh5: 0/249 (0.0%); Ptprc plus a listed subtype marker: 0/249 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=80; detection/mean Pdgfra 76.2%/0.928, Lum 92.5%/6.65, Dcn 98.7%/21.4, Cd34 75.0%/1.34; pericyte pair 13.8%, contractile triple 43.8%, Schwann pair 1.2%, fibroblast pair 98.8% | D7: n=162; detection/mean Pdgfra 48.8%/0.771, Lum 97.5%/33.7, Dcn 100.0%/89.8, Cd34 85.8%/4.34; pericyte pair 3.7%, contractile triple 6.2%, Schwann pair 1.2%, fibroblast pair 100.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Pdgfra 57.1%/1.96, Lum 100.0%/66.5, Dcn 100.0%/206, Cd34 85.7%/6.26; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 100.0%	median detected genes 3417; median mitochondrial fraction 0.024; predicted doublets 1/249; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=complexity_high_removed, cluster=10; source annotation_evidence/markers_complexity_high_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.493183+00:00	supported	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	supported_broad_identity_retained
0	genes_300	0	1750	VSMC	VSMC	supported	Acta2: 99.7% detected, mean 135 versus rest 111; Tagln: 98.3% detected, mean 82.4 versus rest 72.5; Myh11: 95.4% detected, mean 18.4 versus rest 14.9; Cnn1: 22.2% detected, mean 1.05 versus rest 2.3; Entpd1: 29.7% detected, mean 0.833 versus rest 0.633	Other programs remain visible: same-cell pericyte pair and contractile triple 16.1%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	89d21c0e03495ca78ac97cba0060d10aba58fec6a5f9fa8004b1287360ab0dde	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 322/1750 (18.4%); all four pericyte markers: 19/1750 (1.1%); Acta2/Tagln/Myh11: 1650/1750 (94.3%); Cnn1/Entpd1: 189/1750 (10.8%); Plp1/Cnp: 1/1750 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/1750 (0.0%); Pecam1/Cdh5: 0/1750 (0.0%); Ptprc plus a listed subtype marker: 0/1750 (0.0%)	SS: n=1006; detection/mean Acta2 99.7%/126, Tagln 98.4%/71.7, Myh11 94.7%/16.4, Cnn1 17.7%/0.966, Entpd1 20.8%/0.642; pericyte pair 19.7%, contractile triple 93.3%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=731; detection/mean Acta2 99.9%/148, Tagln 98.9%/98.1, Myh11 96.6%/21.2, Cnn1 28.6%/1.18, Entpd1 42.3%/1.11; pericyte pair 16.6%, contractile triple 96.3%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=6 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/46.4, Tagln 50.0%/11.7, Myh11 100.0%/17.6, Cnn1 0.0%/0, Entpd1 0.0%/0; pericyte pair 50.0%, contractile triple 50.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 85.7%/92, Tagln 71.4%/31.9, Myh11 57.1%/15.8, Cnn1 14.3%/1.5, Entpd1 28.6%/0.611; pericyte pair 0.0%, contractile triple 57.1%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1760.5; median mitochondrial fraction 0.0565; predicted doublets 1/1750; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=genes_300, cluster=0; source annotation_evidence/markers_genes_300/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.512972+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
1	genes_300	1	1939	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 144 versus rest 110; Tagln: 99.9% detected, mean 103 versus rest 69.7; Myh11: 98.4% detected, mean 18.7 versus rest 14.8; Cnn1: 43.1% detected, mean 1.88 versus rest 2.21; Entpd1: 49.6% detected, mean 1.05 versus rest 0.603	Other programs remain visible: same-cell pericyte pair and contractile triple 16.4%; pericyte and fibroblast pairs 0.1%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	51de9b1edfcd45e16b82213a409ef46ea1875387a55584ce716d93de89946200	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 331/1939 (17.1%); all four pericyte markers: 29/1939 (1.5%); Acta2/Tagln/Myh11: 1906/1939 (98.3%); Cnn1/Entpd1: 549/1939 (28.3%); Plp1/Cnp: 4/1939 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 2/1939 (0.1%); Pecam1/Cdh5: 0/1939 (0.0%); Ptprc plus a listed subtype marker: 0/1939 (0.0%)	SS: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/120, Tagln 100.0%/73.8, Myh11 100.0%/20.2, Cnn1 28.6%/2.62, Entpd1 57.1%/1.26; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1932; detection/mean Acta2 99.9%/144, Tagln 99.9%/104, Myh11 98.4%/18.7, Cnn1 43.1%/1.87, Entpd1 49.5%/1.05; pericyte pair 17.1%, contractile triple 98.3%, Schwann pair 0.2%, fibroblast pair 0.1% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2444; median mitochondrial fraction 0.0665; predicted doublets 0/1939; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=genes_300, cluster=1; source annotation_evidence/markers_genes_300/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.523525+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
2	genes_300	2	432	Schwann	Schwann	supported	Plp1: 96.8% detected, mean 23 versus rest 0.0545; Cnp: 88.9% detected, mean 13.4 versus rest 0.106	Other programs remain visible: same-cell pericyte pair and contractile triple 1.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 13.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e6f997da9513413875ba350696d03eb9becd30a955298bb06266857351585789	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 14/432 (3.2%); all four pericyte markers: 3/432 (0.7%); Acta2/Tagln/Myh11: 64/432 (14.8%); Cnn1/Entpd1: 10/432 (2.3%); Plp1/Cnp: 378/432 (87.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/432 (0.0%); Pecam1/Cdh5: 0/432 (0.0%); Ptprc plus a listed subtype marker: 0/432 (0.0%)	SS: n=121; detection/mean Plp1 95.0%/22, Cnp 90.1%/18.5; pericyte pair 1.7%, contractile triple 9.1%, Schwann pair 86.8%, fibroblast pair 0.0% | D3: n=215; detection/mean Plp1 97.7%/20.1, Cnp 87.0%/8.13; pericyte pair 5.6%, contractile triple 24.7%, Schwann pair 86.5%, fibroblast pair 0.0% | D7: n=35; detection/mean Plp1 94.3%/31.6, Cnp 85.7%/15.4; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 82.9%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1888; median mitochondrial fraction 0.0288; predicted doublets 5/432; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=genes_300, cluster=2; source annotation_evidence/markers_genes_300/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.542885+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
3	genes_300	3	1968	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 172 versus rest 106; Tagln: 100.0% detected, mean 110 versus rest 68.8; Myh11: 99.5% detected, mean 26.6 versus rest 13.8; Cnn1: 69.6% detected, mean 5.37 versus rest 1.76; Entpd1: 34.2% detected, mean 0.88 versus rest 0.624	Other programs remain visible: same-cell pericyte pair and contractile triple 2.7%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	7f3bb422f907ab998ab05ec2ed8c57046e98180edcf7dab30d7f7c5e22a494b7	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 54/1968 (2.7%); all four pericyte markers: 2/1968 (0.1%); Acta2/Tagln/Myh11: 1958/1968 (99.5%); Cnn1/Entpd1: 521/1968 (26.5%); Plp1/Cnp: 2/1968 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/1968 (0.0%); Pecam1/Cdh5: 0/1968 (0.0%); Ptprc plus a listed subtype marker: 0/1968 (0.0%)	SS: n=1879; detection/mean Acta2 100.0%/171, Tagln 100.0%/109, Myh11 99.6%/26.2, Cnn1 69.1%/5.21, Entpd1 34.0%/0.87; pericyte pair 2.5%, contractile triple 99.6%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=29; detection/mean Acta2 100.0%/178, Tagln 100.0%/116, Myh11 89.7%/29.1, Cnn1 48.3%/4.26, Entpd1 31.0%/1.06; pericyte pair 3.4%, contractile triple 89.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=47; detection/mean Acta2 100.0%/208, Tagln 100.0%/140, Myh11 100.0%/40.3, Cnn1 93.6%/11.4, Entpd1 36.2%/1.01; pericyte pair 6.4%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=13 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/266, Tagln 100.0%/167, Myh11 100.0%/35.1, Cnn1 100.0%/8.86, Entpd1 69.2%/1.41; pericyte pair 23.1%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1908.5; median mitochondrial fraction 0.0674; predicted doublets 6/1968; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=genes_300, cluster=3; source annotation_evidence/markers_genes_300/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.562754+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
4	genes_300	4	3050	VSMC	VSMC	supported	Acta2: 99.3% detected, mean 140 versus rest 108; Tagln: 98.6% detected, mean 70.6 versus rest 74.2; Myh11: 94.4% detected, mean 20.9 versus rest 14; Cnn1: 43.0% detected, mean 3.07 versus rest 1.98; Entpd1: 23.2% detected, mean 0.764 versus rest 0.63	Other programs remain visible: same-cell pericyte pair and contractile triple 8.7%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	4bfe8b6307182d1d7c287770199bf154242959932ae9dae6d642d6996e9b6a57	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 333/3050 (10.9%); all four pericyte markers: 21/3050 (0.7%); Acta2/Tagln/Myh11: 2861/3050 (93.8%); Cnn1/Entpd1: 421/3050 (13.8%); Plp1/Cnp: 1/3050 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/3050 (0.0%); Pecam1/Cdh5: 0/3050 (0.0%); Ptprc plus a listed subtype marker: 0/3050 (0.0%)	SS: n=31; detection/mean Acta2 100.0%/108, Tagln 100.0%/61.7, Myh11 80.6%/15.4, Cnn1 9.7%/0.355, Entpd1 0.0%/0; pericyte pair 16.1%, contractile triple 80.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=14 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/142, Tagln 100.0%/103, Myh11 57.1%/22.9, Cnn1 21.4%/3.01, Entpd1 14.3%/0.625; pericyte pair 14.3%, contractile triple 57.1%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=1377; detection/mean Acta2 98.6%/127, Tagln 97.8%/61.4, Myh11 94.2%/19.4, Cnn1 40.9%/2.9, Entpd1 21.4%/0.738; pericyte pair 10.0%, contractile triple 93.4%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1628; detection/mean Acta2 99.9%/152, Tagln 99.3%/78.3, Myh11 95.2%/22.2, Cnn1 45.6%/3.27, Entpd1 25.3%/0.801; pericyte pair 11.5%, contractile triple 94.7%, Schwann pair 0.1%, fibroblast pair 0.0%	median detected genes 1481.5; median mitochondrial fraction 0.0639; predicted doublets 9/3050; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=genes_300, cluster=4; source annotation_evidence/markers_genes_300/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.582419+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
5	genes_300	5	1448	pericyte	pericyte	supported	Kcnj8: 88.9% detected, mean 31.5 versus rest 3.47; Abcc9: 82.7% detected, mean 12.3 versus rest 2.95; Colec11: 91.2% detected, mean 23.2 versus rest 4.12; Vtn: 91.2% detected, mean 25.8 versus rest 3.96	Other programs remain visible: same-cell pericyte pair and contractile triple 12.2%; pericyte and fibroblast pairs 0.3%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	ec211e230ad63db4346b09c16999d2bc342ebf5cf6b8a87a906d10e6f750d728	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1392/1448 (96.1%); all four pericyte markers: 1013/1448 (70.0%); Acta2/Tagln/Myh11: 193/1448 (13.3%); Cnn1/Entpd1: 0/1448 (0.0%); Plp1/Cnp: 3/1448 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 6/1448 (0.4%); Pecam1/Cdh5: 0/1448 (0.0%); Ptprc plus a listed subtype marker: 0/1448 (0.0%)	SS: n=368; detection/mean Kcnj8 92.1%/26.6, Abcc9 85.1%/12.3, Colec11 94.0%/21.9, Vtn 94.6%/26.3; pericyte pair 98.1%, contractile triple 14.7%, Schwann pair 0.0%, fibroblast pair 0.3% | D3: n=58; detection/mean Kcnj8 77.6%/25.7, Abcc9 58.6%/14.1, Colec11 74.1%/19.3, Vtn 75.9%/19.8; pericyte pair 86.2%, contractile triple 8.6%, Schwann pair 0.0%, fibroblast pair 1.7% | D7: n=302; detection/mean Kcnj8 87.7%/32.1, Abcc9 80.8%/11.2, Colec11 93.0%/25.4, Vtn 90.7%/28.9; pericyte pair 96.4%, contractile triple 9.9%, Schwann pair 0.0%, fibroblast pair 0.7% | D42: n=720; detection/mean Kcnj8 88.6%/34.2, Abcc9 84.2%/12.6, Colec11 90.4%/23.3, Vtn 90.8%/24.6; pericyte pair 95.8%, contractile triple 14.4%, Schwann pair 0.4%, fibroblast pair 0.3%	median detected genes 1236; median mitochondrial fraction 0.0311; predicted doublets 6/1448; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=genes_300, cluster=5; source annotation_evidence/markers_genes_300/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.602476+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
6	genes_300	6	878	pericyte	pericyte	supported	Kcnj8: 74.1% detected, mean 9.7 versus rest 5.63; Abcc9: 68.8% detected, mean 4.41 versus rest 3.7; Colec11: 94.1% detected, mean 24.2 versus rest 4.74; Vtn: 89.2% detected, mean 20.1 versus rest 5.03	Other programs remain visible: same-cell pericyte pair and contractile triple 40.0%; pericyte and fibroblast pairs 8.1%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	d59acd842114bc2115e750a61e04edde8d6a9252f8599f09be6f5e0fe4b356b4	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 828/878 (94.3%); all four pericyte markers: 470/878 (53.5%); Acta2/Tagln/Myh11: 381/878 (43.4%); Cnn1/Entpd1: 15/878 (1.7%); Plp1/Cnp: 2/878 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 95/878 (10.8%); Pecam1/Cdh5: 0/878 (0.0%); Ptprc plus a listed subtype marker: 0/878 (0.0%)	SS: n=76; detection/mean Kcnj8 60.5%/5.77, Abcc9 46.1%/1.88, Colec11 82.9%/20.8, Vtn 73.7%/24.8; pericyte pair 80.3%, contractile triple 69.7%, Schwann pair 0.0%, fibroblast pair 15.8% | D3: n=90; detection/mean Kcnj8 60.0%/2.6, Abcc9 81.1%/3.66, Colec11 92.2%/12.7, Vtn 93.3%/17.7; pericyte pair 95.6%, contractile triple 85.6%, Schwann pair 1.1%, fibroblast pair 17.8% | D7: n=502; detection/mean Kcnj8 79.3%/11.6, Abcc9 75.5%/5.29, Colec11 95.4%/24, Vtn 88.6%/14.9; pericyte pair 95.6%, contractile triple 31.3%, Schwann pair 0.2%, fibroblast pair 11.0% | D42: n=210; detection/mean Kcnj8 72.9%/9.64, Abcc9 55.7%/3.57, Colec11 95.7%/30.7, Vtn 94.3%/31.7; pericyte pair 95.7%, contractile triple 44.8%, Schwann pair 0.0%, fibroblast pair 5.7%	median detected genes 1959.5; median mitochondrial fraction 0.0309; predicted doublets 4/878; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=genes_300, cluster=6; source annotation_evidence/markers_genes_300/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.623243+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
7	genes_300	7	2005	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 153 versus rest 109; Tagln: 100.0% detected, mean 112 versus rest 68.4; Myh11: 99.6% detected, mean 19.3 versus rest 14.7; Cnn1: 52.7% detected, mean 2.26 versus rest 2.16; Entpd1: 55.3% detected, mean 1.12 versus rest 0.591	Other programs remain visible: same-cell pericyte pair and contractile triple 10.0%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	82e1af9f23ee50f622c7dffb35607a4aba926773dc9aaeefbad030fb35750174	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 201/2005 (10.0%); all four pericyte markers: 15/2005 (0.7%); Acta2/Tagln/Myh11: 1997/2005 (99.6%); Cnn1/Entpd1: 696/2005 (34.7%); Plp1/Cnp: 1/2005 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/2005 (0.0%); Pecam1/Cdh5: 0/2005 (0.0%); Ptprc plus a listed subtype marker: 0/2005 (0.0%)	SS: n=20; detection/mean Acta2 100.0%/153, Tagln 100.0%/98.5, Myh11 100.0%/26.9, Cnn1 85.0%/6.04, Entpd1 35.0%/0.685; pericyte pair 5.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1985; detection/mean Acta2 100.0%/153, Tagln 100.0%/112, Myh11 99.6%/19.2, Cnn1 52.3%/2.23, Entpd1 55.5%/1.13; pericyte pair 10.1%, contractile triple 99.6%, Schwann pair 0.1%, fibroblast pair 0.1% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2540; median mitochondrial fraction 0.066; predicted doublets 0/2005; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=genes_300, cluster=7; source annotation_evidence/markers_genes_300/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.633911+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
8	genes_300	8	83	unassigned	unassigned	mixed	Kcnj8: 98.8% detected, mean 7.1 versus rest 5.83; Abcc9: 100.0% detected, mean 7.2 versus rest 3.72; Colec11: 96.4% detected, mean 6.07 versus rest 5.74; Vtn: 94.0% detected, mean 5.1 versus rest 5.81; Myh11: 100.0% detected, mean 18.6 versus rest 15.2; Cnn1: 73.5% detected, mean 2.86 versus rest 2.17; Entpd1: 63.9% detected, mean 1.03 versus rest 0.652; Pdgfra: 0.0% detected, mean 0 versus rest 0.0151; Lum: 2.4% detected, mean 0.0237 versus rest 0.437; Dcn: 12.0% detected, mean 0.0978 versus rest 1.62; Cd34: 3.6% detected, mean 0.0245 versus rest 0.0755	Other programs remain visible: same-cell pericyte pair and contractile triple 100.0%; pericyte and fibroblast pairs 2.4%; Schwann pair and contractile triple 1.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Strong pericyte and VSMC-associated programs occur in the same cells: all four pericyte markers commonly coincide with Acta2/Tagln/Myh11, and Cnn1/Entpd1 coexpression is substantial. Elevated doublet flags and complexity add concern, but do not prove doublets. Pericyte contractile overlap alone would not justify exclusion; the combined unusually strong dual signature leaves mural identity unresolved. Retain all cells in composition denominators, label unassigned, and exclude this cluster from supported-pericyte contrasts. 83 cells: 76 express all four pericyte markers; all 83 express Acta2/Tagln/Myh11; 42 express Cnn1/Entpd1. Eight Scrublet flags are retained in this cohort. Mixed mural identity is not resolved by treating predicted non-doublets as confirmed singlets.	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	d892571d6f15b28e5ca2f4dd77c62b4a2582dd74b5ebd3cfec8df734eb774c2b	SCP002-A001	accepted_versioned_annotation_decision	M	at least two of Kcnj8/Abcc9/Colec11/Vtn: 83/83 (100.0%); all four pericyte markers: 76/83 (91.6%); Acta2/Tagln/Myh11: 83/83 (100.0%); Cnn1/Entpd1: 42/83 (50.6%); Plp1/Cnp: 1/83 (1.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 2/83 (2.4%); Pecam1/Cdh5: 0/83 (0.0%); Ptprc plus a listed subtype marker: 0/83 (0.0%)	SS: n=8 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/11.1, Abcc9 100.0%/6.82, Colec11 100.0%/7.13, Vtn 100.0%/8.51, Myh11 100.0%/22, Cnn1 75.0%/2.91, Entpd1 50.0%/0.783, Pdgfra 0.0%/0, Lum 0.0%/0, Dcn 0.0%/0, Cd34 0.0%/0; pericyte pair 100.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=75; detection/mean Kcnj8 98.7%/6.68, Abcc9 100.0%/7.25, Colec11 96.0%/5.95, Vtn 93.3%/4.74, Myh11 100.0%/18.2, Cnn1 73.3%/2.85, Entpd1 65.3%/1.05, Pdgfra 0.0%/0, Lum 2.7%/0.0262, Dcn 13.3%/0.108, Cd34 4.0%/0.0271; pericyte pair 100.0%, contractile triple 100.0%, Schwann pair 1.3%, fibroblast pair 2.7% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 3665; median mitochondrial fraction 0.0678; predicted doublets 8/83; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=genes_300, cluster=8; source annotation_evidence/markers_genes_300/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.645104+00:00	mixed	Strong pericyte and VSMC-associated programs occur in the same cells: all four pericyte markers commonly coincide with Acta2/Tagln/Myh11, and Cnn1/Entpd1 coexpression is substantial. Elevated doublet flags and complexity add concern, but do not prove doublets. Pericyte contractile overlap alone would not justify exclusion; the combined unusually strong dual signature leaves mural identity unresolved. Retain all cells in composition denominators, label unassigned, and exclude this cluster from supported-pericyte contrasts. 83 cells: 76 express all four pericyte markers; all 83 express Acta2/Tagln/Myh11; 42 express Cnn1/Entpd1. Eight Scrublet flags are retained in this cohort. Mixed mural identity is not resolved by treating predicted non-doublets as confirmed singlets.	proposal_uncertainty_retained
9	genes_300	9	581	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 296 versus rest 107; Tagln: 100.0% detected, mean 236 versus rest 67.8; Myh11: 100.0% detected, mean 34.7 versus rest 14.6; Cnn1: 98.8% detected, mean 8.4 versus rest 1.96; Entpd1: 76.2% detected, mean 1.42 versus rest 0.627	Other programs remain visible: same-cell pericyte pair and contractile triple 6.5%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.3%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	17c9235f6d3b3ede295f45b2a3651172c69d9b438d9254fafa94a68757d3e76d	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 38/581 (6.5%); all four pericyte markers: 5/581 (0.9%); Acta2/Tagln/Myh11: 581/581 (100.0%); Cnn1/Entpd1: 440/581 (75.7%); Plp1/Cnp: 2/581 (0.3%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/581 (0.2%); Pecam1/Cdh5: 0/581 (0.0%); Ptprc plus a listed subtype marker: 0/581 (0.0%)	SS: n=17 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/199, Tagln 100.0%/162, Myh11 100.0%/33.7, Cnn1 88.2%/8.94, Entpd1 35.3%/1.44; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=563; detection/mean Acta2 100.0%/299, Tagln 100.0%/239, Myh11 100.0%/34.8, Cnn1 99.1%/8.36, Entpd1 77.6%/1.42; pericyte pair 6.7%, contractile triple 100.0%, Schwann pair 0.4%, fibroblast pair 0.2% | D7: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/317, Tagln 100.0%/185, Myh11 100.0%/19.8, Cnn1 100.0%/19.8, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 3238; median mitochondrial fraction 0.0845; predicted doublets 0/581; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=genes_300, cluster=9; source annotation_evidence/markers_genes_300/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.660289+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
10	genes_300	10	1803	pericyte	pericyte	supported	Kcnj8: 88.1% detected, mean 21.6 versus rest 3.98; Abcc9: 93.2% detected, mean 19.4 versus rest 1.9; Colec11: 91.6% detected, mean 18.9 versus rest 4.18; Vtn: 91.7% detected, mean 16.5 versus rest 4.55	Other programs remain visible: same-cell pericyte pair and contractile triple 27.6%; pericyte and fibroblast pairs 0.8%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	d955c5f44efa5840d155e6bcc349ae5999ea5ba2a670c054bf4d8f145a47d666	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1750/1803 (97.1%); all four pericyte markers: 1383/1803 (76.7%); Acta2/Tagln/Myh11: 527/1803 (29.2%); Cnn1/Entpd1: 5/1803 (0.3%); Plp1/Cnp: 2/1803 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 15/1803 (0.8%); Pecam1/Cdh5: 0/1803 (0.0%); Ptprc plus a listed subtype marker: 0/1803 (0.0%)	SS: n=22; detection/mean Kcnj8 81.8%/17.1, Abcc9 81.8%/12.4, Colec11 77.3%/14.9, Vtn 81.8%/16.8; pericyte pair 90.9%, contractile triple 18.2%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1781; detection/mean Kcnj8 88.2%/21.6, Abcc9 93.3%/19.5, Colec11 91.7%/19, Vtn 91.9%/16.5; pericyte pair 97.1%, contractile triple 29.4%, Schwann pair 0.1%, fibroblast pair 0.8% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 1758; median mitochondrial fraction 0.0438; predicted doublets 1/1803; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=genes_300, cluster=10; source annotation_evidence/markers_genes_300/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.670700+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
11	genes_300	11	908	pericyte	unassigned	uncertain	Kcnj8: 59.3% detected, mean 3.5 versus rest 5.97; Abcc9: 71.4% detected, mean 3.58 versus rest 3.75; Colec11: 58.5% detected, mean 3.55 versus rest 5.86; Vtn: 78.9% detected, mean 3.78 versus rest 5.92	Other programs remain visible: same-cell pericyte pair and contractile triple 57.3%; pericyte and fibroblast pairs 7.2%; Schwann pair and contractile triple 0.3%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	The pericyte program is plausible but weaker or more heterogeneous than in the clear supported clusters, while a strong VSMC-like contractile program remains. No exclusive marker resolves this boundary. This is not an Acta2/Cspg4 exclusion rule: multiple-marker strength, same-cell concordance, library variation and the unresolved mixture alternative jointly limit confidence. Retain a proposed pericyte interpretation but leave final identity unassigned for quantitative outputs pending separate review. The SS subset (37 cells) has only 32.4% two-marker pericyte concordance, compared with 77.3% in D3 (823 cells); contractile-triple detection is 81.1% and 79.5%, respectively. Cnn1/Entpd1 coexpression is 7.3% overall. Pericyte/contractile overlap is expected, but this heterogeneous boundary does not justify an unqualified whole-cluster pericyte assignment.	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	1b8042bd04ccda5772e6740b78d7c91d45e9930dff41e2d763e83da080bba8a6	SCP002-A001	accepted_versioned_annotation_decision	U	at least two of Kcnj8/Abcc9/Colec11/Vtn: 683/908 (75.2%); all four pericyte markers: 378/908 (41.6%); Acta2/Tagln/Myh11: 714/908 (78.6%); Cnn1/Entpd1: 66/908 (7.3%); Plp1/Cnp: 5/908 (0.6%); at least two of Pdgfra/Lum/Dcn/Cd34: 69/908 (7.6%); Pecam1/Cdh5: 0/908 (0.0%); Ptprc plus a listed subtype marker: 0/908 (0.0%)	SS: n=37; detection/mean Kcnj8 16.2%/1.83, Abcc9 18.9%/1.23, Colec11 32.4%/2.55, Vtn 54.1%/6.03; pericyte pair 32.4%, contractile triple 81.1%, Schwann pair 0.0%, fibroblast pair 2.7% | D3: n=823; detection/mean Kcnj8 61.0%/3.47, Abcc9 74.5%/3.72, Colec11 59.5%/3.5, Vtn 80.7%/3.56; pericyte pair 77.3%, contractile triple 79.5%, Schwann pair 0.5%, fibroblast pair 7.9% | D7: n=38; detection/mean Kcnj8 60.5%/4.66, Abcc9 57.9%/2.24, Colec11 57.9%/4.77, Vtn 65.8%/5.08; pericyte pair 71.1%, contractile triple 68.4%, Schwann pair 2.6%, fibroblast pair 7.9% | D42: n=10 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 70.0%/8.05, Abcc9 60.0%/5.91, Colec11 70.0%/7.3, Vtn 70.0%/8.72; pericyte pair 80.0%, contractile triple 40.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 3894.5; median mitochondrial fraction 0.0417; predicted doublets 0/908; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=genes_300, cluster=11; source annotation_evidence/markers_genes_300/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.690479+00:00	uncertain	The pericyte program is plausible but weaker or more heterogeneous than in the clear supported clusters, while a strong VSMC-like contractile program remains. No exclusive marker resolves this boundary. This is not an Acta2/Cspg4 exclusion rule: multiple-marker strength, same-cell concordance, library variation and the unresolved mixture alternative jointly limit confidence. Retain a proposed pericyte interpretation but leave final identity unassigned for quantitative outputs pending separate review. The SS subset (37 cells) has only 32.4% two-marker pericyte concordance, compared with 77.3% in D3 (823 cells); contractile-triple detection is 81.1% and 79.5%, respectively. Cnn1/Entpd1 coexpression is 7.3% overall. Pericyte/contractile overlap is expected, but this heterogeneous boundary does not justify an unqualified whole-cluster pericyte assignment.	proposal_uncertainty_retained
12	genes_300	12	254	fibroblast	fibroblast	supported	Pdgfra: 58.3% detected, mean 0.853 versus rest 0.00242; Lum: 96.1% detected, mean 25.5 versus rest 0.0569; Dcn: 99.6% detected, mean 70.6 versus rest 0.571; Cd34: 81.9% detected, mean 3.39 versus rest 0.0252	Other programs remain visible: same-cell pericyte pair and contractile triple 2.4%; pericyte and fibroblast pairs 7.5%; Schwann pair and contractile triple 1.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	ad76ec777d98dba2bdb0ed0396bb20c6950d0a93d54d154a7e2d55fdf0b304f3	SCP002-A001	accepted_versioned_annotation_decision	F	at least two of Kcnj8/Abcc9/Colec11/Vtn: 19/254 (7.5%); all four pericyte markers: 4/254 (1.6%); Acta2/Tagln/Myh11: 47/254 (18.5%); Cnn1/Entpd1: 3/254 (1.2%); Plp1/Cnp: 3/254 (1.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 253/254 (99.6%); Pecam1/Cdh5: 0/254 (0.0%); Ptprc plus a listed subtype marker: 0/254 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=82; detection/mean Pdgfra 76.8%/0.923, Lum 92.7%/6.54, Dcn 98.8%/21, Cd34 74.4%/1.32; pericyte pair 14.6%, contractile triple 43.9%, Schwann pair 1.2%, fibroblast pair 98.8% | D7: n=165; detection/mean Pdgfra 49.1%/0.772, Lum 97.6%/33.2, Dcn 100.0%/89.4, Cd34 85.5%/4.31; pericyte pair 4.2%, contractile triple 6.7%, Schwann pair 1.2%, fibroblast pair 100.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Pdgfra 57.1%/1.96, Lum 100.0%/66.5, Dcn 100.0%/206, Cd34 85.7%/6.26; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 100.0%	median detected genes 3424.5; median mitochondrial fraction 0.0239; predicted doublets 0/254; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=genes_300, cluster=12; source annotation_evidence/markers_genes_300/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.705630+00:00	supported	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	supported_broad_identity_retained
0	mito_10	0	2650	VSMC	VSMC	supported	Acta2: 99.8% detected, mean 154 versus rest 101; Tagln: 99.7% detected, mean 94.2 versus rest 65.5; Myh11: 97.7% detected, mean 21.9 versus rest 12.4; Cnn1: 48.2% detected, mean 3.39 versus rest 1.65; Entpd1: 29.2% detected, mean 0.784 versus rest 0.584	Other programs remain visible: same-cell pericyte pair and contractile triple 7.4%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	fc6b8d3f66bb51ae02227be41936852d19499a995452144a955860e39e734a72	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 223/2650 (8.4%); all four pericyte markers: 13/2650 (0.5%); Acta2/Tagln/Myh11: 2582/2650 (97.4%); Cnn1/Entpd1: 472/2650 (17.8%); Plp1/Cnp: 2/2650 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2650 (0.0%); Pecam1/Cdh5: 0/2650 (0.0%); Ptprc plus a listed subtype marker: 0/2650 (0.0%)	SS: n=2597; detection/mean Acta2 99.8%/154, Tagln 99.7%/94.3, Myh11 98.0%/21.8, Cnn1 48.5%/3.39, Entpd1 29.3%/0.786; pericyte pair 8.3%, contractile triple 97.7%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=38; detection/mean Acta2 100.0%/165, Tagln 100.0%/112, Myh11 86.8%/26.3, Cnn1 34.2%/4.3, Entpd1 31.6%/0.738; pericyte pair 13.2%, contractile triple 86.8%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=10 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/108, Tagln 90.0%/48.2, Myh11 100.0%/27.9, Cnn1 30.0%/2.46, Entpd1 10.0%/0.618; pericyte pair 10.0%, contractile triple 90.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=5 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 80.0%/76, Tagln 80.0%/17.5, Myh11 40.0%/10.9, Cnn1 0.0%/0, Entpd1 20.0%/0.556; pericyte pair 20.0%, contractile triple 40.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1803; median mitochondrial fraction 0.0581; predicted doublets 7/2650; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_10, cluster=0; source annotation_evidence/markers_mito_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.725459+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
1	mito_10	1	502	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 289 versus rest 104; Tagln: 100.0% detected, mean 233 versus rest 64.9; Myh11: 100.0% detected, mean 33.8 versus rest 13.4; Cnn1: 99.4% detected, mean 8.77 versus rest 1.72; Entpd1: 75.9% detected, mean 1.39 versus rest 0.593	Other programs remain visible: same-cell pericyte pair and contractile triple 9.6%; pericyte and fibroblast pairs 0.2%; Schwann pair and contractile triple 0.4%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	221479562b0041072f1b3ffa548b8ccf926588a24dbc62f26bc21aa9f500416e	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 48/502 (9.6%); all four pericyte markers: 18/502 (3.6%); Acta2/Tagln/Myh11: 502/502 (100.0%); Cnn1/Entpd1: 380/502 (75.7%); Plp1/Cnp: 2/502 (0.4%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/502 (0.2%); Pecam1/Cdh5: 0/502 (0.0%); Ptprc plus a listed subtype marker: 0/502 (0.0%)	SS: n=31; detection/mean Acta2 100.0%/204, Tagln 100.0%/165, Myh11 100.0%/31.3, Cnn1 100.0%/10.1, Entpd1 45.2%/1.36; pericyte pair 3.2%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=470; detection/mean Acta2 100.0%/295, Tagln 100.0%/238, Myh11 100.0%/33.9, Cnn1 99.4%/8.68, Entpd1 78.1%/1.39; pericyte pair 9.8%, contractile triple 100.0%, Schwann pair 0.4%, fibroblast pair 0.2% | D7: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/166, Tagln 100.0%/126, Myh11 100.0%/52.1, Cnn1 100.0%/10, Entpd1 0.0%/0; pericyte pair 100.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 3324; median mitochondrial fraction 0.0781; predicted doublets 1/502; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_10, cluster=1; source annotation_evidence/markers_mito_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.740695+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
2	mito_10	2	2666	VSMC	VSMC	supported	Acta2: 99.1% detected, mean 141 versus rest 103; Tagln: 98.1% detected, mean 70.9 versus rest 70.3; Myh11: 94.1% detected, mean 19.6 versus rest 12.9; Cnn1: 40.5% detected, mean 2.91 versus rest 1.75; Entpd1: 23.1% detected, mean 0.734 versus rest 0.594	Other programs remain visible: same-cell pericyte pair and contractile triple 10.1%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	fa53039ff818622fc60baf67ebbc4c11650509ddf86f7335807975789009ea03	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 340/2666 (12.8%); all four pericyte markers: 28/2666 (1.1%); Acta2/Tagln/Myh11: 2484/2666 (93.2%); Cnn1/Entpd1: 358/2666 (13.4%); Plp1/Cnp: 1/2666 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2666 (0.0%); Pecam1/Cdh5: 0/2666 (0.0%); Ptprc plus a listed subtype marker: 0/2666 (0.0%)	SS: n=29; detection/mean Acta2 100.0%/138, Tagln 93.1%/73.8, Myh11 86.2%/14.7, Cnn1 31.0%/3.86, Entpd1 10.3%/0.324; pericyte pair 24.1%, contractile triple 79.3%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=9 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/147, Tagln 100.0%/107, Myh11 44.4%/18.8, Cnn1 33.3%/4.67, Entpd1 0.0%/0; pericyte pair 22.2%, contractile triple 44.4%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=1158; detection/mean Acta2 98.0%/125, Tagln 97.0%/60.2, Myh11 93.1%/17.4, Cnn1 35.6%/2.57, Entpd1 20.4%/0.699; pericyte pair 13.4%, contractile triple 91.8%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1470; detection/mean Acta2 99.9%/154, Tagln 99.0%/79, Myh11 95.4%/21.4, Cnn1 44.6%/3.16, Entpd1 25.6%/0.775; pericyte pair 12.0%, contractile triple 94.8%, Schwann pair 0.1%, fibroblast pair 0.0%	median detected genes 1493; median mitochondrial fraction 0.0591; predicted doublets 1/2666; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_10, cluster=2; source annotation_evidence/markers_mito_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.761008+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
3	mito_10	3	1725	VSMC	VSMC	supported	Acta2: 99.6% detected, mean 120 versus rest 108; Tagln: 98.4% detected, mean 82 versus rest 68.9; Myh11: 93.7% detected, mean 15.1 versus rest 13.9; Cnn1: 24.9% detected, mean 0.942 versus rest 2.07; Entpd1: 36.4% detected, mean 0.778 versus rest 0.599	Other programs remain visible: same-cell pericyte pair and contractile triple 37.6%; pericyte and fibroblast pairs 0.2%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	d3f61ca0ac451831b2124650be26006d1c45067f46f2a559f7e1cb59205084b2	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 749/1725 (43.4%); all four pericyte markers: 246/1725 (14.3%); Acta2/Tagln/Myh11: 1604/1725 (93.0%); Cnn1/Entpd1: 259/1725 (15.0%); Plp1/Cnp: 2/1725 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 4/1725 (0.2%); Pecam1/Cdh5: 0/1725 (0.0%); Ptprc plus a listed subtype marker: 0/1725 (0.0%)	SS: n=33; detection/mean Acta2 100.0%/81, Tagln 84.8%/43.6, Myh11 81.8%/11.8, Cnn1 27.3%/1.3, Entpd1 9.1%/0.107; pericyte pair 60.6%, contractile triple 72.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1688; detection/mean Acta2 99.6%/121, Tagln 98.8%/82.8, Myh11 94.0%/15.2, Cnn1 24.9%/0.937, Entpd1 37.0%/0.79; pericyte pair 43.0%, contractile triple 93.4%, Schwann pair 0.1%, fibroblast pair 0.2% | D7: n=4 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/123, Tagln 75.0%/87.3, Myh11 100.0%/8.34, Cnn1 0.0%/0, Entpd1 25.0%/1.2; pericyte pair 75.0%, contractile triple 75.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 2280; median mitochondrial fraction 0.0559; predicted doublets 10/1725; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_10, cluster=3; source annotation_evidence/markers_mito_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.776884+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
4	mito_10	4	412	Schwann	Schwann	supported	Plp1: 96.8% detected, mean 22.7 versus rest 0.0554; Cnp: 91.3% detected, mean 13.9 versus rest 0.11	Other programs remain visible: same-cell pericyte pair and contractile triple 1.7%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 13.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	9d5a4e80a8ce4b447ef4949364a96cf2ff01c8bf2c0fb72e8905ac66bc8b2703	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 14/412 (3.4%); all four pericyte markers: 3/412 (0.7%); Acta2/Tagln/Myh11: 60/412 (14.6%); Cnn1/Entpd1: 9/412 (2.2%); Plp1/Cnp: 370/412 (89.8%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/412 (0.0%); Pecam1/Cdh5: 0/412 (0.0%); Ptprc plus a listed subtype marker: 0/412 (0.0%)	SS: n=121; detection/mean Plp1 95.0%/22, Cnp 90.1%/18.5; pericyte pair 1.7%, contractile triple 9.1%, Schwann pair 86.8%, fibroblast pair 0.0% | D3: n=196; detection/mean Plp1 98.0%/19.3, Cnp 91.3%/8.5; pericyte pair 6.1%, contractile triple 25.0%, Schwann pair 90.8%, fibroblast pair 0.0% | D7: n=34; detection/mean Plp1 94.1%/31.5, Cnp 88.2%/15.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 85.3%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1901.5; median mitochondrial fraction 0.0274; predicted doublets 3/412; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_10, cluster=4; source annotation_evidence/markers_mito_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.798038+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
5	mito_10	5	1363	pericyte	pericyte	supported	Kcnj8: 88.9% detected, mean 31.7 versus rest 3.82; Abcc9: 83.8% detected, mean 12.3 versus rest 3.07; Colec11: 92.2% detected, mean 23.2 versus rest 4.53; Vtn: 91.6% detected, mean 25.9 versus rest 4.35	Other programs remain visible: same-cell pericyte pair and contractile triple 12.7%; pericyte and fibroblast pairs 0.3%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	204fd63bc3126d5f69819777326b97cccd4256b6634696a11972c8bbe5fd3e33	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1316/1363 (96.6%); all four pericyte markers: 965/1363 (70.8%); Acta2/Tagln/Myh11: 190/1363 (13.9%); Cnn1/Entpd1: 0/1363 (0.0%); Plp1/Cnp: 3/1363 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 5/1363 (0.4%); Pecam1/Cdh5: 0/1363 (0.0%); Ptprc plus a listed subtype marker: 0/1363 (0.0%)	SS: n=373; detection/mean Kcnj8 90.6%/25.5, Abcc9 84.2%/11.9, Colec11 93.8%/21.1, Vtn 93.3%/25.6; pericyte pair 98.1%, contractile triple 16.6%, Schwann pair 0.0%, fibroblast pair 0.3% | D3: n=9 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/26.6, Abcc9 77.8%/21.9, Colec11 88.9%/16.6, Vtn 100.0%/22.5; pericyte pair 100.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=273; detection/mean Kcnj8 87.9%/34.1, Abcc9 81.0%/11.3, Colec11 93.0%/26.1, Vtn 90.5%/29.8; pericyte pair 95.6%, contractile triple 7.7%, Schwann pair 0.0%, fibroblast pair 0.7% | D42: n=708; detection/mean Kcnj8 88.3%/34.2, Abcc9 84.7%/12.7, Colec11 91.1%/23.4, Vtn 91.0%/24.6; pericyte pair 96.0%, contractile triple 15.1%, Schwann pair 0.4%, fibroblast pair 0.3%	median detected genes 1256; median mitochondrial fraction 0.031; predicted doublets 2/1363; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_10, cluster=5; source annotation_evidence/markers_mito_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.818030+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
6	mito_10	6	924	pericyte	pericyte	supported	Kcnj8: 74.8% detected, mean 9.47 versus rest 6.07; Abcc9: 69.8% detected, mean 4.33 versus rest 3.85; Colec11: 93.1% detected, mean 23.1 versus rest 5.11; Vtn: 89.3% detected, mean 19.5 versus rest 5.4	Other programs remain visible: same-cell pericyte pair and contractile triple 42.2%; pericyte and fibroblast pairs 9.2%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	95a3830e2b702975f95eae09b5efc8ab406c7fe09dc32c5b7d0b0a01408b0cdd	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 871/924 (94.3%); all four pericyte markers: 499/924 (54.0%); Acta2/Tagln/Myh11: 422/924 (45.7%); Cnn1/Entpd1: 19/924 (2.1%); Plp1/Cnp: 2/924 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 111/924 (12.0%); Pecam1/Cdh5: 0/924 (0.0%); Ptprc plus a listed subtype marker: 0/924 (0.0%)	SS: n=74; detection/mean Kcnj8 60.8%/5.7, Abcc9 44.6%/1.85, Colec11 82.4%/20.5, Vtn 73.0%/24.7; pericyte pair 79.7%, contractile triple 70.3%, Schwann pair 0.0%, fibroblast pair 16.2% | D3: n=135; detection/mean Kcnj8 67.4%/2.81, Abcc9 83.7%/3.22, Colec11 86.7%/9.6, Vtn 94.8%/13.6; pericyte pair 95.6%, contractile triple 86.7%, Schwann pair 0.7%, fibroblast pair 22.2% | D7: n=510; detection/mean Kcnj8 79.6%/11.8, Abcc9 75.7%/5.37, Colec11 95.1%/23.9, Vtn 88.4%/15.4; pericyte pair 95.5%, contractile triple 31.2%, Schwann pair 0.2%, fibroblast pair 11.2% | D42: n=205; detection/mean Kcnj8 72.7%/9.4, Abcc9 55.1%/3.35, Colec11 96.1%/30.6, Vtn 93.7%/31.7; pericyte pair 95.6%, contractile triple 45.9%, Schwann pair 0.0%, fibroblast pair 5.9%	median detected genes 2031.5; median mitochondrial fraction 0.0308; predicted doublets 1/924; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_10, cluster=6; source annotation_evidence/markers_mito_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.837767+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
7	mito_10	7	1412	pericyte	pericyte	supported	Kcnj8: 95.4% detected, mean 25.9 versus rest 4.31; Abcc9: 97.5% detected, mean 21.8 versus rest 2.08; Colec11: 95.0% detected, mean 21.8 versus rest 4.61; Vtn: 94.1% detected, mean 18.7 versus rest 4.99	Other programs remain visible: same-cell pericyte pair and contractile triple 19.8%; pericyte and fibroblast pairs 1.1%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	3017d2902514d10f61cb919fae81ad9966a22c0cf45fcc1b69fd4f248f07126a	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1398/1412 (99.0%); all four pericyte markers: 1228/1412 (87.0%); Acta2/Tagln/Myh11: 282/1412 (20.0%); Cnn1/Entpd1: 0/1412 (0.0%); Plp1/Cnp: 2/1412 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 15/1412 (1.1%); Pecam1/Cdh5: 0/1412 (0.0%); Ptprc plus a listed subtype marker: 0/1412 (0.0%)	SS: n=19 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/27.7, Abcc9 84.2%/12.9, Colec11 100.0%/25, Vtn 89.5%/22.5; pericyte pair 100.0%, contractile triple 10.5%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1390; detection/mean Kcnj8 95.3%/25.8, Abcc9 97.7%/21.9, Colec11 95.0%/21.8, Vtn 94.1%/18.7; pericyte pair 99.0%, contractile triple 20.1%, Schwann pair 0.1%, fibroblast pair 1.1% | D7: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/38.2, Abcc9 100.0%/23.9, Colec11 100.0%/47.8, Vtn 100.0%/38.2; pericyte pair 100.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=2 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/34.3, Abcc9 100.0%/27.4, Colec11 100.0%/23.2, Vtn 100.0%/19.5; pericyte pair 100.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1757.5; median mitochondrial fraction 0.043; predicted doublets 2/1412; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_10, cluster=7; source annotation_evidence/markers_mito_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.857655+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
8	mito_10	8	153	VSMC	VSMC	supported	Acta2: 98.7% detected, mean 121 versus rest 110; Tagln: 98.7% detected, mean 80 versus rest 70.3; Myh11: 93.5% detected, mean 15.9 versus rest 14; Cnn1: 34.6% detected, mean 1.54 versus rest 1.95; Entpd1: 32.7% detected, mean 0.615 versus rest 0.619	Other programs remain visible: same-cell pericyte pair and contractile triple 20.9%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	827570840174f7846b52c895c5c91d80f9005458fd247de8f2ab14bf0f5d737e	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 38/153 (24.8%); all four pericyte markers: 4/153 (2.6%); Acta2/Tagln/Myh11: 143/153 (93.5%); Cnn1/Entpd1: 26/153 (17.0%); Plp1/Cnp: 0/153 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/153 (0.0%); Pecam1/Cdh5: 0/153 (0.0%); Ptprc plus a listed subtype marker: 0/153 (0.0%)	SS: n=29; detection/mean Acta2 100.0%/111, Tagln 100.0%/69.8, Myh11 96.6%/16.8, Cnn1 27.6%/1.41, Entpd1 20.7%/0.514; pericyte pair 17.2%, contractile triple 96.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=74; detection/mean Acta2 100.0%/135, Tagln 100.0%/105, Myh11 100.0%/17.3, Cnn1 43.2%/1.75, Entpd1 55.4%/0.879; pericyte pair 27.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=14 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/112, Tagln 100.0%/42.7, Myh11 92.9%/11.6, Cnn1 35.7%/1.95, Entpd1 0.0%/0; pericyte pair 7.1%, contractile triple 92.9%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=36; detection/mean Acta2 94.4%/105, Tagln 94.4%/50.4, Myh11 77.8%/13.8, Cnn1 22.2%/1.06, Entpd1 8.3%/0.39; pericyte pair 33.3%, contractile triple 77.8%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1984; median mitochondrial fraction 0.0506; predicted doublets 0/153; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_10, cluster=8; source annotation_evidence/markers_mito_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.877512+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
9	mito_10	9	2934	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 145 versus rest 101; Tagln: 100.0% detected, mean 106 versus rest 62.2; Myh11: 99.1% detected, mean 18 versus rest 13.1; Cnn1: 46.3% detected, mean 1.84 versus rest 1.97; Entpd1: 52.7% detected, mean 1.1 versus rest 0.506	Other programs remain visible: same-cell pericyte pair and contractile triple 12.2%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	674732a1d1db55d513073316fc9d6f59819972b1169e00ab507998c3960c5a0a	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 362/2934 (12.3%); all four pericyte markers: 32/2934 (1.1%); Acta2/Tagln/Myh11: 2908/2934 (99.1%); Cnn1/Entpd1: 893/2934 (30.4%); Plp1/Cnp: 2/2934 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/2934 (0.0%); Pecam1/Cdh5: 0/2934 (0.0%); Ptprc plus a listed subtype marker: 0/2934 (0.0%)	SS: n=15 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/146, Tagln 100.0%/87.1, Myh11 93.3%/18.3, Cnn1 60.0%/3.92, Entpd1 33.3%/0.869; pericyte pair 0.0%, contractile triple 93.3%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=2919; detection/mean Acta2 100.0%/145, Tagln 100.0%/106, Myh11 99.1%/18, Cnn1 46.2%/1.83, Entpd1 52.8%/1.1; pericyte pair 12.4%, contractile triple 99.1%, Schwann pair 0.1%, fibroblast pair 0.0% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2490.5; median mitochondrial fraction 0.0633; predicted doublets 0/2934; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_10, cluster=9; source annotation_evidence/markers_mito_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.888280+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
10	mito_10	10	521	pericyte	pericyte	supported	Kcnj8: 77.5% detected, mean 7.54 versus rest 6.23; Abcc9: 82.7% detected, mean 5.69 versus rest 3.81; Colec11: 68.9% detected, mean 6.37 versus rest 6.17; Vtn: 82.3% detected, mean 5.9 versus rest 6.25	Other programs remain visible: same-cell pericyte pair and contractile triple 52.6%; pericyte and fibroblast pairs 9.6%; Schwann pair and contractile triple 0.6%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	fe40ab4e50b2f761eb88b5189756d7a5b5f94b0e86a3d0979de73bd5f0ac8df6	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 454/521 (87.1%); all four pericyte markers: 288/521 (55.3%); Acta2/Tagln/Myh11: 306/521 (58.7%); Cnn1/Entpd1: 10/521 (1.9%); Plp1/Cnp: 5/521 (1.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 52/521 (10.0%); Pecam1/Cdh5: 0/521 (0.0%); Ptprc plus a listed subtype marker: 0/521 (0.0%)	SS: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 57.1%/9.87, Abcc9 57.1%/3.71, Colec11 57.1%/8.6, Vtn 100.0%/17.1; pericyte pair 71.4%, contractile triple 42.9%, Schwann pair 0.0%, fibroblast pair 14.3% | D3: n=477; detection/mean Kcnj8 78.0%/7.25, Abcc9 84.9%/5.92, Colec11 69.6%/6.3, Vtn 83.4%/5.65; pericyte pair 88.1%, contractile triple 60.0%, Schwann pair 0.8%, fibroblast pair 10.1% | D7: n=28; detection/mean Kcnj8 67.9%/5.74, Abcc9 60.7%/2.14, Colec11 60.7%/4.6, Vtn 64.3%/4.54; pericyte pair 75.0%, contractile triple 60.7%, Schwann pair 3.6%, fibroblast pair 10.7% | D42: n=9 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/26.7, Abcc9 55.6%/6.12, Colec11 66.7%/13.7, Vtn 66.7%/14.7; pericyte pair 88.9%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 4221; median mitochondrial fraction 0.0354; predicted doublets 0/521; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_10, cluster=10; source annotation_evidence/markers_mito_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.908186+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
11	mito_10	11	247	fibroblast	fibroblast	supported	Pdgfra: 58.3% detected, mean 0.796 versus rest 0.00265; Lum: 96.8% detected, mean 26.1 versus rest 0.0613; Dcn: 99.6% detected, mean 71.5 versus rest 0.622; Cd34: 82.6% detected, mean 3.45 versus rest 0.0274	Other programs remain visible: same-cell pericyte pair and contractile triple 2.0%; pericyte and fibroblast pairs 7.3%; Schwann pair and contractile triple 1.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	23e19e86f6813ebaf4bcf3c37023d7efec8c47a2d37534a5d18c43ed0ff1df90	SCP002-A001	accepted_versioned_annotation_decision	F	at least two of Kcnj8/Abcc9/Colec11/Vtn: 18/247 (7.3%); all four pericyte markers: 4/247 (1.6%); Acta2/Tagln/Myh11: 45/247 (18.2%); Cnn1/Entpd1: 3/247 (1.2%); Plp1/Cnp: 3/247 (1.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 246/247 (99.6%); Pecam1/Cdh5: 0/247 (0.0%); Ptprc plus a listed subtype marker: 0/247 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=79; detection/mean Pdgfra 75.9%/0.72, Lum 93.7%/6.67, Dcn 98.7%/21.2, Cd34 75.9%/1.33; pericyte pair 15.2%, contractile triple 44.3%, Schwann pair 1.3%, fibroblast pair 98.7% | D7: n=161; detection/mean Pdgfra 49.7%/0.783, Lum 98.1%/33.9, Dcn 100.0%/90.3, Cd34 85.7%/4.37; pericyte pair 3.7%, contractile triple 6.2%, Schwann pair 1.2%, fibroblast pair 100.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Pdgfra 57.1%/1.96, Lum 100.0%/66.5, Dcn 100.0%/206, Cd34 85.7%/6.26; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 100.0%	median detected genes 3463; median mitochondrial fraction 0.0238; predicted doublets 0/247; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_10, cluster=11; source annotation_evidence/markers_mito_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.923154+00:00	supported	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	supported_broad_identity_retained
0	mito_20	0	2954	VSMC	VSMC	supported	Acta2: 99.7% detected, mean 153 versus rest 105; Tagln: 99.4% detected, mean 94.7 versus rest 68.9; Myh11: 97.9% detected, mean 23 versus rest 14; Cnn1: 50.6% detected, mean 3.63 versus rest 1.9; Entpd1: 29.0% detected, mean 0.789 versus rest 0.631	Other programs remain visible: same-cell pericyte pair and contractile triple 7.1%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	fc58c515860865fe99ab9602c532c8b22a2bd7d954218b34e474c57cc26ce893	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 244/2954 (8.3%); all four pericyte markers: 14/2954 (0.5%); Acta2/Tagln/Myh11: 2876/2954 (97.4%); Cnn1/Entpd1: 543/2954 (18.4%); Plp1/Cnp: 2/2954 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2954 (0.0%); Pecam1/Cdh5: 0/2954 (0.0%); Ptprc plus a listed subtype marker: 0/2954 (0.0%)	SS: n=2885; detection/mean Acta2 99.7%/153, Tagln 99.4%/94.4, Myh11 97.9%/22.8, Cnn1 50.6%/3.61, Entpd1 28.9%/0.783; pericyte pair 8.2%, contractile triple 97.4%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=48; detection/mean Acta2 100.0%/183, Tagln 100.0%/124, Myh11 97.9%/28.8, Cnn1 50.0%/3.84, Entpd1 35.4%/0.973; pericyte pair 12.5%, contractile triple 97.9%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=18 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/142, Tagln 88.9%/81.4, Myh11 100.0%/35.1, Cnn1 66.7%/6.48, Entpd1 38.9%/1.26; pericyte pair 5.6%, contractile triple 88.9%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=3 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/118, Tagln 100.0%/32.7, Myh11 100.0%/24.8, Cnn1 0.0%/0, Entpd1 33.3%/0.926; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1803; median mitochondrial fraction 0.0611; predicted doublets 4/2954; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_20, cluster=0; source annotation_evidence/markers_mito_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.942883+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
1	mito_20	1	2031	pericyte	pericyte	supported	Kcnj8: 86.4% detected, mean 25.1 versus rest 3.2; Abcc9: 80.6% detected, mean 9.87 versus rest 2.94; Colec11: 94.9% detected, mean 25.2 versus rest 3.08; Vtn: 92.1% detected, mean 25.3 versus rest 3.14	Other programs remain visible: same-cell pericyte pair and contractile triple 20.7%; pericyte and fibroblast pairs 3.7%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	c0fdfe7a464ce8274e0691501dd44b7e3a53e179f6e7aa31ad6c4a59da54feb1	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1967/2031 (96.8%); all four pericyte markers: 1402/2031 (69.0%); Acta2/Tagln/Myh11: 450/2031 (22.2%); Cnn1/Entpd1: 15/2031 (0.7%); Plp1/Cnp: 4/2031 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 101/2031 (5.0%); Pecam1/Cdh5: 0/2031 (0.0%); Ptprc plus a listed subtype marker: 0/2031 (0.0%)	SS: n=426; detection/mean Kcnj8 87.1%/23.3, Abcc9 79.6%/10.5, Colec11 94.1%/21.8, Vtn 93.0%/26.5; pericyte pair 96.5%, contractile triple 25.6%, Schwann pair 0.2%, fibroblast pair 3.3% | D3: n=111; detection/mean Kcnj8 66.7%/6.57, Abcc9 81.1%/6.18, Colec11 92.8%/13.8, Vtn 91.9%/17.8; pericyte pair 95.5%, contractile triple 70.3%, Schwann pair 0.9%, fibroblast pair 14.4% | D7: n=708; detection/mean Kcnj8 85.2%/20.8, Abcc9 79.7%/7.87, Colec11 95.9%/26.2, Vtn 90.1%/21.5; pericyte pair 96.5%, contractile triple 21.2%, Schwann pair 0.1%, fibroblast pair 8.1% | D42: n=786; detection/mean Kcnj8 89.9%/32.6, Abcc9 81.8%/11.9, Colec11 94.7%/27.7, Vtn 93.4%/29.2; pericyte pair 97.6%, contractile triple 14.4%, Schwann pair 0.1%, fibroblast pair 1.8%	median detected genes 1463; median mitochondrial fraction 0.031; predicted doublets 11/2031; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_20, cluster=1; source annotation_evidence/markers_mito_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.962484+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
2	mito_20	2	771	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 286 versus rest 106; Tagln: 100.0% detected, mean 226 versus rest 66.2; Myh11: 100.0% detected, mean 34.4 versus rest 14.6; Cnn1: 98.6% detected, mean 8.43 versus rest 1.91; Entpd1: 73.7% detected, mean 1.38 versus rest 0.625	Other programs remain visible: same-cell pericyte pair and contractile triple 5.4%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.3%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	635a4c9fce4d9e47100ab0575ef81383770a84405ab8e9bb2c7dd03711f980bf	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 42/771 (5.4%); all four pericyte markers: 5/771 (0.6%); Acta2/Tagln/Myh11: 771/771 (100.0%); Cnn1/Entpd1: 565/771 (73.3%); Plp1/Cnp: 2/771 (0.3%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/771 (0.1%); Pecam1/Cdh5: 0/771 (0.0%); Ptprc plus a listed subtype marker: 0/771 (0.0%)	SS: n=70; detection/mean Acta2 100.0%/240, Tagln 100.0%/176, Myh11 100.0%/36.2, Cnn1 95.7%/11.6, Entpd1 47.1%/1.26; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=698; detection/mean Acta2 100.0%/291, Tagln 100.0%/231, Myh11 100.0%/34.1, Cnn1 99.0%/8.11, Entpd1 76.6%/1.4; pericyte pair 6.0%, contractile triple 100.0%, Schwann pair 0.3%, fibroblast pair 0.1% | D7: n=3 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/252, Tagln 100.0%/164, Myh11 100.0%/54, Cnn1 66.7%/10.2, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 3149; median mitochondrial fraction 0.085; predicted doublets 0/771; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_20, cluster=2; source annotation_evidence/markers_mito_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.977692+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
3	mito_20	3	436	Schwann	Schwann	supported	Plp1: 96.6% detected, mean 23 versus rest 0.0539; Cnp: 88.3% detected, mean 13.3 versus rest 0.104	Other programs remain visible: same-cell pericyte pair and contractile triple 1.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 12.8%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	9590336f92d46ebd462d9be8433681980e9a1682101be336088699aa2ff61189	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 14/436 (3.2%); all four pericyte markers: 3/436 (0.7%); Acta2/Tagln/Myh11: 65/436 (14.9%); Cnn1/Entpd1: 10/436 (2.3%); Plp1/Cnp: 379/436 (86.9%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/436 (0.0%); Pecam1/Cdh5: 0/436 (0.0%); Ptprc plus a listed subtype marker: 0/436 (0.0%)	SS: n=122; detection/mean Plp1 95.1%/22.1, Cnp 90.2%/18.4; pericyte pair 1.6%, contractile triple 9.0%, Schwann pair 86.9%, fibroblast pair 0.0% | D3: n=218; detection/mean Plp1 97.2%/20, Cnp 85.8%/8.01; pericyte pair 5.5%, contractile triple 24.8%, Schwann pair 85.3%, fibroblast pair 0.0% | D7: n=35; detection/mean Plp1 94.3%/31.6, Cnp 85.7%/15.4; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 82.9%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1868; median mitochondrial fraction 0.0289; predicted doublets 4/436; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_20, cluster=3; source annotation_evidence/markers_mito_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:57.997052+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
4	mito_20	4	3460	VSMC	VSMC	supported	Acta2: 97.8% detected, mean 132 versus rest 109; Tagln: 95.8% detected, mean 66.7 versus rest 74.9; Myh11: 91.1% detected, mean 20.1 versus rest 14.4; Cnn1: 40.8% detected, mean 3.01 versus rest 1.99; Entpd1: 22.1% detected, mean 0.722 versus rest 0.642	Other programs remain visible: same-cell pericyte pair and contractile triple 10.9%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	b65d8e1af1236b6c4539e25cf9c79280f7b7b3e991569a1f9c9af4edc1348523	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 587/3460 (17.0%); all four pericyte markers: 103/3460 (3.0%); Acta2/Tagln/Myh11: 3091/3460 (89.3%); Cnn1/Entpd1: 468/3460 (13.5%); Plp1/Cnp: 3/3460 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/3460 (0.0%); Pecam1/Cdh5: 0/3460 (0.0%); Ptprc plus a listed subtype marker: 0/3460 (0.0%)	SS: n=50; detection/mean Acta2 96.0%/78.9, Tagln 82.0%/44, Myh11 66.0%/11.5, Cnn1 14.0%/0.756, Entpd1 4.0%/0.132; pericyte pair 30.0%, contractile triple 60.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=63; detection/mean Acta2 90.5%/56.6, Tagln 74.6%/36.7, Myh11 33.3%/8.69, Cnn1 6.3%/0.941, Entpd1 3.2%/0.139; pericyte pair 57.1%, contractile triple 23.8%, Schwann pair 0.0%, fibroblast pair 1.6% | D7: n=1545; detection/mean Acta2 97.3%/123, Tagln 95.5%/60.4, Myh11 92.0%/19.5, Cnn1 40.7%/3.08, Entpd1 21.1%/0.722; pericyte pair 14.7%, contractile triple 90.2%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1802; detection/mean Acta2 98.5%/144, Tagln 97.2%/73.7, Myh11 93.0%/21.3, Cnn1 42.7%/3.08, Entpd1 24.2%/0.759; pericyte pair 17.1%, contractile triple 91.7%, Schwann pair 0.2%, fibroblast pair 0.0%	median detected genes 1466; median mitochondrial fraction 0.0628; predicted doublets 12/3460; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_20, cluster=4; source annotation_evidence/markers_mito_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.016885+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
5	mito_20	5	1625	pericyte	pericyte	supported	Kcnj8: 91.7% detected, mean 23.8 versus rest 3.9; Abcc9: 96.9% detected, mean 21.6 versus rest 1.91; Colec11: 91.3% detected, mean 20.3 versus rest 4.15; Vtn: 91.2% detected, mean 17.4 versus rest 4.52	Other programs remain visible: same-cell pericyte pair and contractile triple 21.9%; pericyte and fibroblast pairs 1.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	ba0d311cd430241af47dee2fa359951997628c92d9fa1bdc07b87b8dce208822	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1584/1625 (97.5%); all four pericyte markers: 1321/1625 (81.3%); Acta2/Tagln/Myh11: 365/1625 (22.5%); Cnn1/Entpd1: 0/1625 (0.0%); Plp1/Cnp: 2/1625 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 16/1625 (1.0%); Pecam1/Cdh5: 0/1625 (0.0%); Ptprc plus a listed subtype marker: 0/1625 (0.0%)	SS: n=26; detection/mean Kcnj8 80.8%/19.1, Abcc9 88.5%/13.2, Colec11 80.8%/16.9, Vtn 69.2%/14; pericyte pair 88.5%, contractile triple 11.5%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1595; detection/mean Kcnj8 92.0%/23.9, Abcc9 97.0%/21.7, Colec11 91.7%/20.4, Vtn 91.7%/17.5; pericyte pair 97.7%, contractile triple 22.7%, Schwann pair 0.1%, fibroblast pair 1.0% | D7: n=4 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 25.0%/2.05, Abcc9 100.0%/32, Colec11 25.0%/9.45, Vtn 50.0%/5.86; pericyte pair 75.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 1728; median mitochondrial fraction 0.0448; predicted doublets 0/1625; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_20, cluster=5; source annotation_evidence/markers_mito_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.031883+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
6	mito_20	6	2815	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 155 versus rest 106; Tagln: 99.9% detected, mean 113 versus rest 65.7; Myh11: 99.6% detected, mean 20.5 versus rest 14.5; Cnn1: 56.8% detected, mean 2.37 versus rest 2.16; Entpd1: 56.2% detected, mean 1.16 versus rest 0.561	Other programs remain visible: same-cell pericyte pair and contractile triple 7.5%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	70b3ebabeefdf700addb8cb867de81e5e67571f01e62560c02d9fc536c9f527c	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 211/2815 (7.5%); all four pericyte markers: 13/2815 (0.5%); Acta2/Tagln/Myh11: 2803/2815 (99.6%); Cnn1/Entpd1: 1048/2815 (37.2%); Plp1/Cnp: 1/2815 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/2815 (0.0%); Pecam1/Cdh5: 0/2815 (0.0%); Ptprc plus a listed subtype marker: 0/2815 (0.0%)	SS: n=18 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 94.4%/127, Tagln 100.0%/80.3, Myh11 94.4%/21.1, Cnn1 66.7%/4.12, Entpd1 38.9%/0.856; pericyte pair 5.6%, contractile triple 94.4%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=2797; detection/mean Acta2 100.0%/156, Tagln 99.9%/113, Myh11 99.7%/20.5, Cnn1 56.7%/2.36, Entpd1 56.3%/1.17; pericyte pair 7.5%, contractile triple 99.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2555; median mitochondrial fraction 0.0706; predicted doublets 0/2815; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_20, cluster=6; source annotation_evidence/markers_mito_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.042519+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
7	mito_20	7	158	VSMC	VSMC	supported	Acta2: 98.7% detected, mean 122 versus rest 113; Tagln: 98.7% detected, mean 79.8 versus rest 73.2; Myh11: 93.0% detected, mean 16 versus rest 15.5; Cnn1: 36.7% detected, mean 1.65 versus rest 2.2; Entpd1: 33.5% detected, mean 0.668 versus rest 0.658	Other programs remain visible: same-cell pericyte pair and contractile triple 20.9%; pericyte and fibroblast pairs 0.6%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	bd9f194464cd42c2d36e58222adb5d40e5d22ce5c8f91afb2a94d337e022512f	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 40/158 (25.3%); all four pericyte markers: 5/158 (3.2%); Acta2/Tagln/Myh11: 147/158 (93.0%); Cnn1/Entpd1: 27/158 (17.1%); Plp1/Cnp: 0/158 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/158 (0.6%); Pecam1/Cdh5: 0/158 (0.0%); Ptprc plus a listed subtype marker: 0/158 (0.0%)	SS: n=27; detection/mean Acta2 100.0%/112, Tagln 100.0%/70.2, Myh11 92.6%/16.6, Cnn1 29.6%/1.51, Entpd1 25.9%/0.914; pericyte pair 18.5%, contractile triple 92.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=78; detection/mean Acta2 100.0%/133, Tagln 100.0%/103, Myh11 100.0%/17.3, Cnn1 44.9%/1.79, Entpd1 55.1%/0.856; pericyte pair 26.9%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=16 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/115, Tagln 100.0%/47.4, Myh11 93.8%/13.7, Cnn1 37.5%/2.34, Entpd1 0.0%/0; pericyte pair 12.5%, contractile triple 93.8%, Schwann pair 0.0%, fibroblast pair 6.2% | D42: n=37; detection/mean Acta2 94.6%/109, Tagln 94.6%/52.1, Myh11 78.4%/13.9, Cnn1 24.3%/1.14, Entpd1 8.1%/0.38; pericyte pair 32.4%, contractile triple 78.4%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2066; median mitochondrial fraction 0.0508; predicted doublets 0/158; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_20, cluster=7; source annotation_evidence/markers_mito_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.062329+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
8	mito_20	8	2446	VSMC	VSMC	supported	Acta2: 99.6% detected, mean 115 versus rest 113; Tagln: 98.6% detected, mean 80 versus rest 72.2; Myh11: 94.8% detected, mean 15.7 versus rest 15.5; Cnn1: 22.4% detected, mean 0.84 versus rest 2.41; Entpd1: 37.7% detected, mean 0.839 versus rest 0.628	Other programs remain visible: same-cell pericyte pair and contractile triple 34.4%; pericyte and fibroblast pairs 0.2%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	ec272d995ef06c580f3f998ece4504aa3d57931d1a8f01a7f78ebd70480c032e	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 928/2446 (37.9%); all four pericyte markers: 256/2446 (10.5%); Acta2/Tagln/Myh11: 2305/2446 (94.2%); Cnn1/Entpd1: 337/2446 (13.8%); Plp1/Cnp: 5/2446 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 6/2446 (0.2%); Pecam1/Cdh5: 0/2446 (0.0%); Ptprc plus a listed subtype marker: 0/2446 (0.0%)	SS: n=25; detection/mean Acta2 100.0%/74.1, Tagln 88.0%/48.3, Myh11 84.0%/13.2, Cnn1 36.0%/1.37, Entpd1 20.0%/0.357; pericyte pair 84.0%, contractile triple 76.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=2412; detection/mean Acta2 99.6%/116, Tagln 98.8%/80.5, Myh11 95.0%/15.7, Cnn1 22.3%/0.836, Entpd1 38.0%/0.844; pericyte pair 37.4%, contractile triple 94.5%, Schwann pair 0.2%, fibroblast pair 0.2% | D7: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 85.7%/81.4, Tagln 57.1%/54, Myh11 85.7%/14, Cnn1 0.0%/0, Entpd1 14.3%/0.685; pericyte pair 42.9%, contractile triple 57.1%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=2 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/86.7, Tagln 100.0%/37.8, Myh11 100.0%/18.4, Cnn1 50.0%/2.29, Entpd1 50.0%/2.29; pericyte pair 50.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2242; median mitochondrial fraction 0.0583; predicted doublets 6/2446; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_20, cluster=8; source annotation_evidence/markers_mito_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.082356+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
9	mito_20	9	563	pericyte	pericyte	supported	Kcnj8: 75.3% detected, mean 5.12 versus rest 5.77; Abcc9: 85.4% detected, mean 5.03 versus rest 3.7; Colec11: 68.2% detected, mean 4.65 versus rest 5.68; Vtn: 83.8% detected, mean 4.67 versus rest 5.75	Other programs remain visible: same-cell pericyte pair and contractile triple 59.5%; pericyte and fibroblast pairs 11.2%; Schwann pair and contractile triple 0.5%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	a1d70343852130416e4510fd3550940abdb857ab5ffa49eed993bf8272f1cfaa	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 491/563 (87.2%); all four pericyte markers: 315/563 (56.0%); Acta2/Tagln/Myh11: 377/563 (67.0%); Cnn1/Entpd1: 14/563 (2.5%); Plp1/Cnp: 5/563 (0.9%); at least two of Pdgfra/Lum/Dcn/Cd34: 66/563 (11.7%); Pecam1/Cdh5: 0/563 (0.0%); Ptprc plus a listed subtype marker: 0/563 (0.0%)	SS: n=5 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 40.0%/7.64, Abcc9 60.0%/3.26, Colec11 60.0%/10.4, Vtn 100.0%/24.7; pericyte pair 60.0%, contractile triple 60.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=521; detection/mean Kcnj8 76.0%/5.05, Abcc9 86.9%/5.2, Colec11 68.7%/4.58, Vtn 84.6%/4.41; pericyte pair 87.9%, contractile triple 67.6%, Schwann pair 0.8%, fibroblast pair 12.1% | D7: n=33; detection/mean Kcnj8 66.7%/5.15, Abcc9 63.6%/2, Colec11 60.6%/4.74, Vtn 69.7%/5.33; pericyte pair 78.8%, contractile triple 66.7%, Schwann pair 3.0%, fibroblast pair 9.1% | D42: n=4 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/10.9, Abcc9 100.0%/9.87, Colec11 75.0%/5.82, Vtn 75.0%/7.56; pericyte pair 100.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 4385; median mitochondrial fraction 0.0362; predicted doublets 0/563; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_20, cluster=9; source annotation_evidence/markers_mito_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.102359+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
10	mito_20	10	254	fibroblast	fibroblast	supported	Pdgfra: 58.3% detected, mean 0.853 versus rest 0.00236; Lum: 95.7% detected, mean 25.5 versus rest 0.0564; Dcn: 99.6% detected, mean 70.3 versus rest 0.566; Cd34: 81.9% detected, mean 3.39 versus rest 0.025	Other programs remain visible: same-cell pericyte pair and contractile triple 2.4%; pericyte and fibroblast pairs 7.5%; Schwann pair and contractile triple 1.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	72189e973d94db99ab7d3a4e3e5ebfe5d70a7a4499d3e54f98ad184fd09f3c67	SCP002-A001	accepted_versioned_annotation_decision	F	at least two of Kcnj8/Abcc9/Colec11/Vtn: 19/254 (7.5%); all four pericyte markers: 4/254 (1.6%); Acta2/Tagln/Myh11: 47/254 (18.5%); Cnn1/Entpd1: 3/254 (1.2%); Plp1/Cnp: 3/254 (1.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 252/254 (99.2%); Pecam1/Cdh5: 0/254 (0.0%); Ptprc plus a listed subtype marker: 0/254 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=82; detection/mean Pdgfra 76.8%/0.923, Lum 92.7%/6.54, Dcn 98.8%/21, Cd34 74.4%/1.32; pericyte pair 14.6%, contractile triple 43.9%, Schwann pair 1.2%, fibroblast pair 98.8% | D7: n=165; detection/mean Pdgfra 49.1%/0.772, Lum 97.0%/33.2, Dcn 100.0%/89, Cd34 85.5%/4.31; pericyte pair 4.2%, contractile triple 6.7%, Schwann pair 1.2%, fibroblast pair 99.4% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Pdgfra 57.1%/1.96, Lum 100.0%/66.5, Dcn 100.0%/206, Cd34 85.7%/6.26; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 100.0%	median detected genes 3424.5; median mitochondrial fraction 0.0239; predicted doublets 0/254; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mito_20, cluster=10; source annotation_evidence/markers_mito_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.117801+00:00	supported	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	supported_broad_identity_retained
0	mitotic_panel_removed	0	2899	VSMC	VSMC	supported	Acta2: 99.8% detected, mean 156 versus rest 105; Tagln: 99.6% detected, mean 97 versus rest 68.7; Myh11: 98.1% detected, mean 23.1 versus rest 13.7; Cnn1: 51.4% detected, mean 3.76 versus rest 1.85; Entpd1: 29.9% detected, mean 0.813 versus rest 0.621	Other programs remain visible: same-cell pericyte pair and contractile triple 6.9%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	7335b00facd5fcecd1e685b452ece2d58582ed7eafb88baf4d19427d4ea70820	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 222/2899 (7.7%); all four pericyte markers: 10/2899 (0.3%); Acta2/Tagln/Myh11: 2833/2899 (97.7%); Cnn1/Entpd1: 553/2899 (19.1%); Plp1/Cnp: 3/2899 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2899 (0.0%); Pecam1/Cdh5: 0/2899 (0.0%); Ptprc plus a listed subtype marker: 0/2899 (0.0%)	SS: n=2840; detection/mean Acta2 99.8%/156, Tagln 99.6%/96.7, Myh11 98.2%/22.9, Cnn1 51.4%/3.74, Entpd1 29.7%/0.802; pericyte pair 7.7%, contractile triple 97.8%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=44; detection/mean Acta2 100.0%/178, Tagln 100.0%/120, Myh11 93.2%/26.7, Cnn1 45.5%/3.83, Entpd1 36.4%/1.4; pericyte pair 6.8%, contractile triple 93.2%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=11 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/134, Tagln 100.0%/107, Myh11 100.0%/38.8, Cnn1 63.6%/7.79, Entpd1 36.4%/1.46; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=4 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/149, Tagln 100.0%/50, Myh11 100.0%/27.6, Cnn1 25.0%/2.62, Entpd1 50.0%/1.07; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1816; median mitochondrial fraction 0.0608; predicted doublets 7/2899; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mitotic_panel_removed, cluster=0; source annotation_evidence/markers_mitotic_panel_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.137608+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
1	mitotic_panel_removed	1	2171	pericyte	pericyte	supported	Kcnj8: 78.8% detected, mean 23.9 versus rest 3.21; Abcc9: 73.9% detected, mean 9.62 versus rest 2.89; Colec11: 85.9% detected, mean 20.9 versus rest 3.54; Vtn: 85.3% detected, mean 20.5 versus rest 3.66	Other programs remain visible: same-cell pericyte pair and contractile triple 15.7%; pericyte and fibroblast pairs 1.2%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	7802061d2d06968d2e3ba21cd890039f693a9d510a86399b9640d49664a87899	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1927/2171 (88.8%); all four pericyte markers: 1305/2171 (60.1%); Acta2/Tagln/Myh11: 514/2171 (23.7%); Cnn1/Entpd1: 1/2171 (0.0%); Plp1/Cnp: 4/2171 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 27/2171 (1.2%); Pecam1/Cdh5: 0/2171 (0.0%); Ptprc plus a listed subtype marker: 0/2171 (0.0%)	SS: n=409; detection/mean Kcnj8 88.5%/24.5, Abcc9 81.2%/11.4, Colec11 92.7%/20.5, Vtn 93.9%/24.6; pericyte pair 97.1%, contractile triple 18.3%, Schwann pair 0.0%, fibroblast pair 0.2% | D3: n=64; detection/mean Kcnj8 70.3%/23.1, Abcc9 59.4%/13.8, Colec11 71.9%/17.9, Vtn 70.3%/17.9; pericyte pair 81.2%, contractile triple 10.9%, Schwann pair 0.0%, fibroblast pair 1.6% | D7: n=745; detection/mean Kcnj8 81.5%/20.4, Abcc9 76.6%/7.85, Colec11 89.8%/23.7, Vtn 87.5%/19.4; pericyte pair 91.8%, contractile triple 19.9%, Schwann pair 0.1%, fibroblast pair 3.0% | D42: n=953; detection/mean Kcnj8 73.0%/26.4, Abcc9 69.7%/9.97, Colec11 80.8%/19, Vtn 80.9%/19.9; pericyte pair 83.3%, contractile triple 29.8%, Schwann pair 0.3%, fibroblast pair 0.3%	median detected genes 1354; median mitochondrial fraction 0.0324; predicted doublets 7/2171; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mitotic_panel_removed, cluster=1; source annotation_evidence/markers_mitotic_panel_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.157283+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
2	mitotic_panel_removed	2	802	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 265 versus rest 106; Tagln: 100.0% detected, mean 210 versus rest 66.8; Myh11: 100.0% detected, mean 32 versus rest 14.4; Cnn1: 95.8% detected, mean 7.42 versus rest 1.92; Entpd1: 74.7% detected, mean 1.34 versus rest 0.62	Other programs remain visible: same-cell pericyte pair and contractile triple 16.3%; pericyte and fibroblast pairs 0.2%; Schwann pair and contractile triple 0.4%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	2a5b864005cfae262424698250cc7332a5efcc3766a0ebae57b33f0690437b7c	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 131/802 (16.3%); all four pericyte markers: 83/802 (10.3%); Acta2/Tagln/Myh11: 802/802 (100.0%); Cnn1/Entpd1: 582/802 (72.6%); Plp1/Cnp: 3/802 (0.4%); at least two of Pdgfra/Lum/Dcn/Cd34: 3/802 (0.4%); Pecam1/Cdh5: 0/802 (0.0%); Ptprc plus a listed subtype marker: 0/802 (0.0%)	SS: n=31; detection/mean Acta2 100.0%/166, Tagln 100.0%/136, Myh11 100.0%/28.2, Cnn1 83.9%/6.96, Entpd1 38.7%/1.18; pericyte pair 32.3%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=770; detection/mean Acta2 100.0%/269, Tagln 100.0%/213, Myh11 100.0%/32.2, Cnn1 96.2%/7.42, Entpd1 76.2%/1.34; pericyte pair 15.7%, contractile triple 100.0%, Schwann pair 0.4%, fibroblast pair 0.4% | D7: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/317, Tagln 100.0%/185, Myh11 100.0%/19.8, Cnn1 100.0%/19.8, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 3267; median mitochondrial fraction 0.0829; predicted doublets 9/802; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mitotic_panel_removed, cluster=2; source annotation_evidence/markers_mitotic_panel_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.172518+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
3	mitotic_panel_removed	3	3035	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 132 versus rest 110; Tagln: 99.3% detected, mean 92.2 versus rest 69.5; Myh11: 97.0% detected, mean 17.5 versus rest 14.8; Cnn1: 32.3% detected, mean 1.25 versus rest 2.37; Entpd1: 43.7% detected, mean 0.963 versus rest 0.586	Other programs remain visible: same-cell pericyte pair and contractile triple 22.7%; pericyte and fibroblast pairs 0.1%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	a655035822cba57dfaee5a17e4a12b891e2f9b70d0e07e4a5e627cbf050e92b0	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 747/3035 (24.6%); all four pericyte markers: 131/3035 (4.3%); Acta2/Tagln/Myh11: 2934/3035 (96.7%); Cnn1/Entpd1: 620/3035 (20.4%); Plp1/Cnp: 4/3035 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 3/3035 (0.1%); Pecam1/Cdh5: 0/3035 (0.0%); Ptprc plus a listed subtype marker: 0/3035 (0.0%)	SS: n=23; detection/mean Acta2 100.0%/81.9, Tagln 82.6%/42.3, Myh11 78.3%/11.3, Cnn1 13.0%/0.799, Entpd1 8.7%/0.181; pericyte pair 34.8%, contractile triple 69.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=3006; detection/mean Acta2 99.9%/133, Tagln 99.5%/92.6, Myh11 97.1%/17.6, Cnn1 32.5%/1.26, Entpd1 44.0%/0.97; pericyte pair 24.5%, contractile triple 96.9%, Schwann pair 0.1%, fibroblast pair 0.1% | D7: n=5 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/113, Tagln 60.0%/69.8, Myh11 100.0%/9.5, Cnn1 0.0%/0, Entpd1 20.0%/0.959; pericyte pair 60.0%, contractile triple 60.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/45.4, Tagln 100.0%/2.39, Myh11 100.0%/4.78, Cnn1 0.0%/0, Entpd1 0.0%/0; pericyte pair 100.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2340; median mitochondrial fraction 0.0635; predicted doublets 0/3035; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mitotic_panel_removed, cluster=3; source annotation_evidence/markers_mitotic_panel_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.192479+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
4	mitotic_panel_removed	4	128	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 119 versus rest 114; Tagln: 100.0% detected, mean 86.1 versus rest 73.4; Myh11: 98.4% detected, mean 15.4 versus rest 15.3; Cnn1: 35.2% detected, mean 1.39 versus rest 2.18; Entpd1: 46.1% detected, mean 0.764 versus rest 0.652	Other programs remain visible: same-cell pericyte pair and contractile triple 30.5%; pericyte and fibroblast pairs 0.8%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	c66e9f5cd044ae9de296f30869d3ebdc85f0c64d96b38bf2471c31fb9314e102	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 40/128 (31.2%); all four pericyte markers: 9/128 (7.0%); Acta2/Tagln/Myh11: 126/128 (98.4%); Cnn1/Entpd1: 26/128 (20.3%); Plp1/Cnp: 0/128 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/128 (0.8%); Pecam1/Cdh5: 0/128 (0.0%); Ptprc plus a listed subtype marker: 0/128 (0.0%)	SS: n=25; detection/mean Acta2 100.0%/116, Tagln 100.0%/67.8, Myh11 96.0%/17.4, Cnn1 32.0%/1.64, Entpd1 24.0%/0.596; pericyte pair 12.0%, contractile triple 96.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=97; detection/mean Acta2 100.0%/120, Tagln 100.0%/93.2, Myh11 100.0%/14.8, Cnn1 35.1%/1.25, Entpd1 53.6%/0.835; pericyte pair 36.1%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 1.0% | D7: n=2 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/94, Tagln 100.0%/50.5, Myh11 100.0%/17.9, Cnn1 100.0%/3.62, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=4 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/102, Tagln 100.0%/48.1, Myh11 75.0%/15.2, Cnn1 25.0%/1.88, Entpd1 25.0%/0.469; pericyte pair 50.0%, contractile triple 75.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2738.5; median mitochondrial fraction 0.0506; predicted doublets 0/128; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mitotic_panel_removed, cluster=4; source annotation_evidence/markers_mitotic_panel_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.212407+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
5	mitotic_panel_removed	5	1895	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 154 versus rest 109; Tagln: 100.0% detected, mean 114 versus rest 68.5; Myh11: 99.6% detected, mean 19.4 versus rest 14.7; Cnn1: 54.7% detected, mean 2.39 versus rest 2.15; Entpd1: 55.5% detected, mean 1.12 versus rest 0.595	Other programs remain visible: same-cell pericyte pair and contractile triple 10.5%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e5eca1e38ed48356aa8dfbbec87e65c1423fe7aea066c33c049d226ee4409810	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 200/1895 (10.6%); all four pericyte markers: 14/1895 (0.7%); Acta2/Tagln/Myh11: 1887/1895 (99.6%); Cnn1/Entpd1: 684/1895 (36.1%); Plp1/Cnp: 1/1895 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/1895 (0.1%); Pecam1/Cdh5: 0/1895 (0.0%); Ptprc plus a listed subtype marker: 0/1895 (0.0%)	SS: n=24; detection/mean Acta2 100.0%/158, Tagln 100.0%/102, Myh11 100.0%/27.4, Cnn1 83.3%/6.05, Entpd1 37.5%/0.744; pericyte pair 4.2%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1871; detection/mean Acta2 100.0%/154, Tagln 100.0%/114, Myh11 99.6%/19.3, Cnn1 54.4%/2.34, Entpd1 55.7%/1.12; pericyte pair 10.6%, contractile triple 99.6%, Schwann pair 0.1%, fibroblast pair 0.1% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2560; median mitochondrial fraction 0.0666; predicted doublets 0/1895; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mitotic_panel_removed, cluster=5; source annotation_evidence/markers_mitotic_panel_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.222949+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
6	mitotic_panel_removed	6	2817	VSMC	VSMC	supported	Acta2: 99.5% detected, mean 147 versus rest 107; Tagln: 98.9% detected, mean 74.6 versus rest 73.3; Myh11: 95.6% detected, mean 22.1 versus rest 13.9; Cnn1: 48.0% detected, mean 3.52 versus rest 1.91; Entpd1: 25.1% detected, mean 0.819 versus rest 0.621	Other programs remain visible: same-cell pericyte pair and contractile triple 6.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	bbce44750db4d09e360b8f8bb4e6293ac2a0e4b301a8d9c093199efd14be9635	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 218/2817 (7.7%); all four pericyte markers: 11/2817 (0.4%); Acta2/Tagln/Myh11: 2680/2817 (95.1%); Cnn1/Entpd1: 445/2817 (15.8%); Plp1/Cnp: 1/2817 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2817 (0.0%); Pecam1/Cdh5: 0/2817 (0.0%); Ptprc plus a listed subtype marker: 0/2817 (0.0%)	SS: n=29; detection/mean Acta2 100.0%/134, Tagln 96.6%/70.6, Myh11 86.2%/17.9, Cnn1 24.1%/2.56, Entpd1 6.9%/0.224; pericyte pair 3.4%, contractile triple 82.8%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=11 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/163, Tagln 100.0%/120, Myh11 54.5%/24.9, Cnn1 18.2%/2.51, Entpd1 18.2%/0.796; pericyte pair 0.0%, contractile triple 54.5%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=1346; detection/mean Acta2 99.0%/132, Tagln 98.4%/65.2, Myh11 95.0%/20.6, Cnn1 44.3%/3.28, Entpd1 22.4%/0.764; pericyte pair 8.5%, contractile triple 94.4%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1431; detection/mean Acta2 99.9%/161, Tagln 99.4%/83.1, Myh11 96.7%/23.7, Cnn1 52.1%/3.77, Entpd1 28.2%/0.883; pericyte pair 7.2%, contractile triple 96.4%, Schwann pair 0.1%, fibroblast pair 0.0%	median detected genes 1502; median mitochondrial fraction 0.0668; predicted doublets 5/2817; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mitotic_panel_removed, cluster=6; source annotation_evidence/markers_mitotic_panel_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.242870+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
7	mitotic_panel_removed	7	432	Schwann	Schwann	supported	Plp1: 96.8% detected, mean 23 versus rest 0.0544; Cnp: 88.9% detected, mean 13.4 versus rest 0.106	Other programs remain visible: same-cell pericyte pair and contractile triple 1.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 13.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e6f997da9513413875ba350696d03eb9becd30a955298bb06266857351585789	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 14/432 (3.2%); all four pericyte markers: 3/432 (0.7%); Acta2/Tagln/Myh11: 64/432 (14.8%); Cnn1/Entpd1: 10/432 (2.3%); Plp1/Cnp: 378/432 (87.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/432 (0.0%); Pecam1/Cdh5: 0/432 (0.0%); Ptprc plus a listed subtype marker: 0/432 (0.0%)	SS: n=121; detection/mean Plp1 95.0%/22, Cnp 90.1%/18.5; pericyte pair 1.7%, contractile triple 9.1%, Schwann pair 86.8%, fibroblast pair 0.0% | D3: n=215; detection/mean Plp1 97.7%/20.1, Cnp 87.0%/8.13; pericyte pair 5.6%, contractile triple 24.7%, Schwann pair 86.5%, fibroblast pair 0.0% | D7: n=35; detection/mean Plp1 94.3%/31.6, Cnp 85.7%/15.4; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 82.9%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1888; median mitochondrial fraction 0.0288; predicted doublets 4/432; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mitotic_panel_removed, cluster=7; source annotation_evidence/markers_mitotic_panel_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.262280+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
8	mitotic_panel_removed	8	1052	pericyte	pericyte	supported	Kcnj8: 69.5% detected, mean 5.56 versus rest 5.86; Abcc9: 72.5% detected, mean 4.07 versus rest 3.72; Colec11: 80.3% detected, mean 13 versus rest 5.26; Vtn: 86.0% detected, mean 13.7 versus rest 5.28	Other programs remain visible: same-cell pericyte pair and contractile triple 58.6%; pericyte and fibroblast pairs 10.8%; Schwann pair and contractile triple 0.4%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	76e33d0ba6edf5f9af1dc2ce4e0dc9d7c061a9f050509cd4ecfe37cd0af1171e	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 939/1052 (89.3%); all four pericyte markers: 520/1052 (49.4%); Acta2/Tagln/Myh11: 684/1052 (65.0%); Cnn1/Entpd1: 28/1052 (2.7%); Plp1/Cnp: 6/1052 (0.6%); at least two of Pdgfra/Lum/Dcn/Cd34: 142/1052 (13.5%); Pecam1/Cdh5: 0/1052 (0.0%); Ptprc plus a listed subtype marker: 0/1052 (0.0%)	SS: n=78; detection/mean Kcnj8 57.7%/5.43, Abcc9 44.9%/1.82, Colec11 80.8%/19.3, Vtn 75.6%/25.4; pericyte pair 78.2%, contractile triple 70.5%, Schwann pair 0.0%, fibroblast pair 16.7% | D3: n=610; detection/mean Kcnj8 74.6%/5.02, Abcc9 86.9%/5.12, Colec11 73.3%/6.13, Vtn 86.6%/6.53; pericyte pair 89.7%, contractile triple 69.3%, Schwann pair 0.8%, fibroblast pair 13.0% | D7: n=165; detection/mean Kcnj8 53.9%/3.38, Abcc9 53.9%/2.05, Colec11 86.7%/15, Vtn 80.0%/14; pericyte pair 85.5%, contractile triple 69.7%, Schwann pair 0.6%, fibroblast pair 23.6% | D42: n=199; detection/mean Kcnj8 71.4%/9.07, Abcc9 54.8%/3.39, Colec11 96.5%/30.1, Vtn 93.5%/30.9; pericyte pair 95.5%, contractile triple 45.7%, Schwann pair 0.0%, fibroblast pair 5.5%	median detected genes 2985.5; median mitochondrial fraction 0.0333; predicted doublets 2/1052; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mitotic_panel_removed, cluster=8; source annotation_evidence/markers_mitotic_panel_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.281780+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
9	mitotic_panel_removed	9	1623	pericyte	pericyte	supported	Kcnj8: 92.1% detected, mean 23.5 versus rest 3.99; Abcc9: 96.5% detected, mean 21 versus rest 1.93; Colec11: 92.5% detected, mean 20.3 versus rest 4.22; Vtn: 92.1% detected, mean 17.4 versus rest 4.58	Other programs remain visible: same-cell pericyte pair and contractile triple 23.7%; pericyte and fibroblast pairs 0.9%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	66bbb29ebed5e364dfde7606fed963d0357f2a1fdcdbef8444a492cf13bd773f	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1591/1623 (98.0%); all four pericyte markers: 1328/1623 (81.8%); Acta2/Tagln/Myh11: 393/1623 (24.2%); Cnn1/Entpd1: 5/1623 (0.3%); Plp1/Cnp: 2/1623 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 15/1623 (0.9%); Pecam1/Cdh5: 0/1623 (0.0%); Ptprc plus a listed subtype marker: 0/1623 (0.0%)	SS: n=14 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 78.6%/20.4, Abcc9 92.9%/14.5, Colec11 85.7%/21.3, Vtn 78.6%/18.9; pericyte pair 92.9%, contractile triple 21.4%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1609; detection/mean Kcnj8 92.2%/23.5, Abcc9 96.6%/21.1, Colec11 92.6%/20.3, Vtn 92.2%/17.4; pericyte pair 98.1%, contractile triple 24.2%, Schwann pair 0.1%, fibroblast pair 0.9% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 1743; median mitochondrial fraction 0.0443; predicted doublets 2/1623; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mitotic_panel_removed, cluster=9; source annotation_evidence/markers_mitotic_panel_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.292711+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
10	mitotic_panel_removed	10	253	fibroblast	fibroblast	supported	Pdgfra: 58.5% detected, mean 0.857 versus rest 0.00242; Lum: 96.0% detected, mean 25.6 versus rest 0.0572; Dcn: 99.6% detected, mean 70.5 versus rest 0.575; Cd34: 82.2% detected, mean 3.41 versus rest 0.0252	Other programs remain visible: same-cell pericyte pair and contractile triple 2.4%; pericyte and fibroblast pairs 7.5%; Schwann pair and contractile triple 1.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	67bba9cd4d8503380422318f4b2d504cf5d46795d72bca7a6e63d5f9e35a516b	SCP002-A001	accepted_versioned_annotation_decision	F	at least two of Kcnj8/Abcc9/Colec11/Vtn: 19/253 (7.5%); all four pericyte markers: 4/253 (1.6%); Acta2/Tagln/Myh11: 47/253 (18.6%); Cnn1/Entpd1: 3/253 (1.2%); Plp1/Cnp: 3/253 (1.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 252/253 (99.6%); Pecam1/Cdh5: 0/253 (0.0%); Ptprc plus a listed subtype marker: 0/253 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=82; detection/mean Pdgfra 76.8%/0.923, Lum 92.7%/6.54, Dcn 98.8%/21, Cd34 74.4%/1.32; pericyte pair 14.6%, contractile triple 43.9%, Schwann pair 1.2%, fibroblast pair 98.8% | D7: n=164; detection/mean Pdgfra 49.4%/0.777, Lum 97.6%/33.4, Dcn 100.0%/89.5, Cd34 86.0%/4.33; pericyte pair 4.3%, contractile triple 6.7%, Schwann pair 1.2%, fibroblast pair 100.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Pdgfra 57.1%/1.96, Lum 100.0%/66.5, Dcn 100.0%/206, Cd34 85.7%/6.26; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 100.0%	median detected genes 3432; median mitochondrial fraction 0.0239; predicted doublets 0/253; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=mitotic_panel_removed, cluster=10; source annotation_evidence/markers_mitotic_panel_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.307963+00:00	supported	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	supported_broad_identity_retained
0	neighbors_10	0	898	VSMC	VSMC	supported	Acta2: 99.2% detected, mean 126 versus rest 113; Tagln: 96.7% detected, mean 75.8 versus rest 73.4; Myh11: 91.3% detected, mean 17.5 versus rest 15.1; Cnn1: 19.0% detected, mean 0.824 versus rest 2.25; Entpd1: 25.5% detected, mean 0.741 versus rest 0.648	Other programs remain visible: same-cell pericyte pair and contractile triple 18.4%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	18ab03928d57f606dca3edbe1aee40fa9fac5b877acab6f404c6df984b0a8aed	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 207/898 (23.1%); all four pericyte markers: 14/898 (1.6%); Acta2/Tagln/Myh11: 801/898 (89.2%); Cnn1/Entpd1: 79/898 (8.8%); Plp1/Cnp: 1/898 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/898 (0.0%); Pecam1/Cdh5: 0/898 (0.0%); Ptprc plus a listed subtype marker: 0/898 (0.0%)	SS: n=567; detection/mean Acta2 99.3%/112, Tagln 96.6%/62.8, Myh11 90.5%/14.7, Cnn1 13.6%/0.664, Entpd1 16.4%/0.519; pericyte pair 31.0%, contractile triple 88.0%, Schwann pair 0.2%, fibroblast pair 0.0% | D3: n=297; detection/mean Acta2 99.7%/160, Tagln 98.3%/106, Myh11 95.6%/23.6, Cnn1 31.6%/1.22, Entpd1 45.5%/1.23; pericyte pair 7.4%, contractile triple 94.9%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=17 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 94.1%/71.2, Tagln 88.2%/34, Myh11 76.5%/13.6, Cnn1 0.0%/0, Entpd1 5.9%/0.385; pericyte pair 29.4%, contractile triple 70.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=17 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 94.1%/71.6, Tagln 76.5%/26, Myh11 58.8%/8.97, Cnn1 0.0%/0, Entpd1 0.0%/0; pericyte pair 23.5%, contractile triple 47.1%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1644; median mitochondrial fraction 0.0535; predicted doublets 0/898; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=0; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.328346+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
1	neighbors_10	1	1457	pericyte	pericyte	supported	Kcnj8: 87.4% detected, mean 30.9 versus rest 3.5; Abcc9: 81.7% detected, mean 12.2 versus rest 2.96; Colec11: 90.9% detected, mean 23 versus rest 4.14; Vtn: 90.4% detected, mean 25.5 versus rest 3.97	Other programs remain visible: same-cell pericyte pair and contractile triple 12.7%; pericyte and fibroblast pairs 0.3%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	b0d74ff0d1247ca8f50ce7bef6b862fa03bc6c303a97abf838d76a4651ef7f4f	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1389/1457 (95.3%); all four pericyte markers: 1002/1457 (68.8%); Acta2/Tagln/Myh11: 212/1457 (14.6%); Cnn1/Entpd1: 0/1457 (0.0%); Plp1/Cnp: 3/1457 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 6/1457 (0.4%); Pecam1/Cdh5: 0/1457 (0.0%); Ptprc plus a listed subtype marker: 0/1457 (0.0%)	SS: n=345; detection/mean Kcnj8 92.8%/27.1, Abcc9 86.7%/12.8, Colec11 95.4%/22.5, Vtn 95.1%/27.2; pericyte pair 98.6%, contractile triple 13.9%, Schwann pair 0.0%, fibroblast pair 0.3% | D3: n=62; detection/mean Kcnj8 72.6%/23.9, Abcc9 58.1%/13, Colec11 74.2%/18, Vtn 72.6%/18.3; pericyte pair 83.9%, contractile triple 11.3%, Schwann pair 0.0%, fibroblast pair 1.6% | D7: n=305; detection/mean Kcnj8 85.9%/31.4, Abcc9 79.3%/10.9, Colec11 92.1%/25, Vtn 90.8%/28.7; pericyte pair 95.4%, contractile triple 11.8%, Schwann pair 0.0%, fibroblast pair 0.7% | D42: n=745; detection/mean Kcnj8 86.8%/33, Abcc9 82.3%/12.3, Colec11 89.8%/22.7, Vtn 89.5%/24; pericyte pair 94.8%, contractile triple 16.2%, Schwann pair 0.4%, fibroblast pair 0.3%	median detected genes 1237; median mitochondrial fraction 0.0314; predicted doublets 5/1457; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=1; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.347951+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
2	neighbors_10	2	432	Schwann	Schwann	supported	Plp1: 96.8% detected, mean 23 versus rest 0.0544; Cnp: 88.9% detected, mean 13.4 versus rest 0.106	Other programs remain visible: same-cell pericyte pair and contractile triple 1.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 13.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e6f997da9513413875ba350696d03eb9becd30a955298bb06266857351585789	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 14/432 (3.2%); all four pericyte markers: 3/432 (0.7%); Acta2/Tagln/Myh11: 64/432 (14.8%); Cnn1/Entpd1: 10/432 (2.3%); Plp1/Cnp: 378/432 (87.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/432 (0.0%); Pecam1/Cdh5: 0/432 (0.0%); Ptprc plus a listed subtype marker: 0/432 (0.0%)	SS: n=121; detection/mean Plp1 95.0%/22, Cnp 90.1%/18.5; pericyte pair 1.7%, contractile triple 9.1%, Schwann pair 86.8%, fibroblast pair 0.0% | D3: n=215; detection/mean Plp1 97.7%/20.1, Cnp 87.0%/8.13; pericyte pair 5.6%, contractile triple 24.7%, Schwann pair 86.5%, fibroblast pair 0.0% | D7: n=35; detection/mean Plp1 94.3%/31.6, Cnp 85.7%/15.4; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 82.9%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1888; median mitochondrial fraction 0.0288; predicted doublets 4/432; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=2; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.367744+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
3	neighbors_10	3	2092	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 155 versus rest 108; Tagln: 99.9% detected, mean 95.7 versus rest 70.4; Myh11: 99.1% detected, mean 23.2 versus rest 14.1; Cnn1: 54.6% detected, mean 3.74 versus rest 1.96; Entpd1: 30.7% detected, mean 0.829 versus rest 0.629	Other programs remain visible: same-cell pericyte pair and contractile triple 3.3%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	746883c8347253451174ec3fb5c7b9d6a192485f87dd3e40f03dfaa52db1c52e	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 71/2092 (3.4%); all four pericyte markers: 2/2092 (0.1%); Acta2/Tagln/Myh11: 2071/2092 (99.0%); Cnn1/Entpd1: 409/2092 (19.6%); Plp1/Cnp: 2/2092 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2092 (0.0%); Pecam1/Cdh5: 0/2092 (0.0%); Ptprc plus a listed subtype marker: 0/2092 (0.0%)	SS: n=2053; detection/mean Acta2 99.9%/156, Tagln 99.9%/95.8, Myh11 99.3%/23.2, Cnn1 54.9%/3.75, Entpd1 30.6%/0.811; pericyte pair 3.4%, contractile triple 99.2%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=32; detection/mean Acta2 100.0%/161, Tagln 100.0%/106, Myh11 90.6%/25.7, Cnn1 40.6%/3.19, Entpd1 34.4%/1.65; pericyte pair 6.2%, contractile triple 90.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=6 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/64.7, Tagln 100.0%/48.8, Myh11 83.3%/29.6, Cnn1 50.0%/3.63, Entpd1 33.3%/2.32; pericyte pair 0.0%, contractile triple 83.3%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/120, Tagln 100.0%/19.5, Myh11 100.0%/38.9, Cnn1 0.0%/0, Entpd1 100.0%/2.78; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1828; median mitochondrial fraction 0.0618; predicted doublets 7/2092; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=3; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.387922+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
4	neighbors_10	4	536	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 253 versus rest 109; Tagln: 100.0% detected, mean 173 versus rest 70.3; Myh11: 99.8% detected, mean 34.9 versus rest 14.6; Cnn1: 96.8% detected, mean 9.57 versus rest 1.93; Entpd1: 48.9% detected, mean 1.15 versus rest 0.637	Other programs remain visible: same-cell pericyte pair and contractile triple 3.2%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	41c78a3370188351fda6cf20faa3d699596b0f2e620a250b3b2dddcfe2097bfe	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 18/536 (3.4%); all four pericyte markers: 3/536 (0.6%); Acta2/Tagln/Myh11: 535/536 (99.8%); Cnn1/Entpd1: 258/536 (48.1%); Plp1/Cnp: 0/536 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/536 (0.0%); Pecam1/Cdh5: 0/536 (0.0%); Ptprc plus a listed subtype marker: 0/536 (0.0%)	SS: n=283; detection/mean Acta2 100.0%/231, Tagln 100.0%/161, Myh11 99.6%/34.8, Cnn1 96.1%/9.54, Entpd1 44.2%/1.13; pericyte pair 2.5%, contractile triple 99.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=93; detection/mean Acta2 100.0%/306, Tagln 100.0%/247, Myh11 100.0%/37, Cnn1 97.8%/7.85, Entpd1 76.3%/1.38; pericyte pair 6.5%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=62; detection/mean Acta2 100.0%/249, Tagln 100.0%/147, Myh11 100.0%/34.3, Cnn1 96.8%/11.9, Entpd1 27.4%/0.803; pericyte pair 1.6%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=98; detection/mean Acta2 100.0%/266, Tagln 100.0%/151, Myh11 100.0%/33.5, Cnn1 98.0%/9.83, Entpd1 50.0%/1.21; pericyte pair 4.1%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2091; median mitochondrial fraction 0.084; predicted doublets 0/536; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=4; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.407980+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
5	neighbors_10	5	2876	VSMC	VSMC	supported	Acta2: 99.3% detected, mean 137 versus rest 109; Tagln: 98.6% detected, mean 68.6 versus rest 74.5; Myh11: 94.7% detected, mean 20.9 versus rest 14.1; Cnn1: 42.1% detected, mean 2.89 versus rest 2.03; Entpd1: 23.3% detected, mean 0.772 versus rest 0.629	Other programs remain visible: same-cell pericyte pair and contractile triple 8.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	b6ba02b8f7453dd02abdcd284e76cc58361e80cef6021578932795affa063a9a	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 306/2876 (10.6%); all four pericyte markers: 22/2876 (0.8%); Acta2/Tagln/Myh11: 2706/2876 (94.1%); Cnn1/Entpd1: 385/2876 (13.4%); Plp1/Cnp: 1/2876 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2876 (0.0%); Pecam1/Cdh5: 0/2876 (0.0%); Ptprc plus a listed subtype marker: 0/2876 (0.0%)	SS: n=29; detection/mean Acta2 100.0%/115, Tagln 96.6%/68.2, Myh11 79.3%/17.1, Cnn1 24.1%/1.51, Entpd1 13.8%/0.396; pericyte pair 20.7%, contractile triple 75.9%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=13 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/160, Tagln 100.0%/115, Myh11 53.8%/23.9, Cnn1 23.1%/3.24, Entpd1 15.4%/0.673; pericyte pair 0.0%, contractile triple 53.8%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=1333; detection/mean Acta2 98.6%/125, Tagln 97.7%/60.6, Myh11 94.4%/19.6, Cnn1 40.7%/2.83, Entpd1 21.9%/0.746; pericyte pair 10.2%, contractile triple 93.5%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1501; detection/mean Acta2 99.9%/147, Tagln 99.3%/75.3, Myh11 95.7%/22, Cnn1 43.8%/2.97, Entpd1 24.9%/0.803; pericyte pair 10.9%, contractile triple 95.3%, Schwann pair 0.1%, fibroblast pair 0.0%	median detected genes 1477.5; median mitochondrial fraction 0.0639; predicted doublets 6/2876; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=5; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.428735+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
6	neighbors_10	6	1741	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 136 versus rest 111; Tagln: 100.0% detected, mean 99.7 versus rest 70.6; Myh11: 99.5% detected, mean 17.2 versus rest 15; Cnn1: 43.8% detected, mean 1.54 versus rest 2.25; Entpd1: 51.7% detected, mean 1.06 versus rest 0.607	Other programs remain visible: same-cell pericyte pair and contractile triple 11.5%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	3ee8787ed03404939c7a527e52db6f71e41a4bdcf4bf2c40bacf50660d736639	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 202/1741 (11.6%); all four pericyte markers: 13/1741 (0.7%); Acta2/Tagln/Myh11: 1733/1741 (99.5%); Cnn1/Entpd1: 474/1741 (27.2%); Plp1/Cnp: 0/1741 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/1741 (0.1%); Pecam1/Cdh5: 0/1741 (0.0%); Ptprc plus a listed subtype marker: 0/1741 (0.0%)	SS: n=13 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/130, Tagln 100.0%/72.8, Myh11 100.0%/24.7, Cnn1 61.5%/3.69, Entpd1 30.8%/0.631; pericyte pair 7.7%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1728; detection/mean Acta2 100.0%/137, Tagln 100.0%/99.9, Myh11 99.5%/17.2, Cnn1 43.6%/1.53, Entpd1 51.9%/1.06; pericyte pair 11.6%, contractile triple 99.5%, Schwann pair 0.0%, fibroblast pair 0.1% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2473; median mitochondrial fraction 0.0629; predicted doublets 0/1741; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=6; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.440452+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
7	neighbors_10	7	2530	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 128 versus rest 111; Tagln: 99.4% detected, mean 89.8 versus rest 70.7; Myh11: 96.5% detected, mean 16.5 versus rest 15; Cnn1: 31.3% detected, mean 1.24 versus rest 2.34; Entpd1: 42.2% detected, mean 0.908 versus rest 0.609	Other programs remain visible: same-cell pericyte pair and contractile triple 26.0%; pericyte and fibroblast pairs 0.1%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	ec6882a37f4749a8c3dcac5300dfed948463dc173edaed1f589dc94e363dbba7	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 721/2530 (28.5%); all four pericyte markers: 127/2530 (5.0%); Acta2/Tagln/Myh11: 2436/2530 (96.3%); Cnn1/Entpd1: 495/2530 (19.6%); Plp1/Cnp: 4/2530 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 3/2530 (0.1%); Pecam1/Cdh5: 0/2530 (0.0%); Ptprc plus a listed subtype marker: 0/2530 (0.0%)	SS: n=19 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/81, Tagln 84.2%/43.7, Myh11 78.9%/11.1, Cnn1 10.5%/0.64, Entpd1 5.3%/0.0937; pericyte pair 42.1%, contractile triple 73.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=2507; detection/mean Acta2 100.0%/128, Tagln 99.5%/90.1, Myh11 96.6%/16.6, Cnn1 31.5%/1.24, Entpd1 42.5%/0.914; pericyte pair 28.3%, contractile triple 96.5%, Schwann pair 0.2%, fibroblast pair 0.1% | D7: n=4 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/123, Tagln 75.0%/87.3, Myh11 100.0%/8.34, Cnn1 0.0%/0, Entpd1 25.0%/1.2; pericyte pair 75.0%, contractile triple 75.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 2349.5; median mitochondrial fraction 0.061; predicted doublets 0/2530; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=7; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.457636+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
8	neighbors_10	8	163	VSMC	VSMC	supported	Acta2: 97.5% detected, mean 110 versus rest 114; Tagln: 97.5% detected, mean 75.3 versus rest 73.5; Myh11: 92.0% detected, mean 14.4 versus rest 15.3; Cnn1: 32.5% detected, mean 1.37 versus rest 2.18; Entpd1: 37.4% detected, mean 0.661 versus rest 0.653	Other programs remain visible: same-cell pericyte pair and contractile triple 30.7%; pericyte and fibroblast pairs 0.6%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	0be59221e8683dd127a52767cecbcc6c15b33e9c03e6bb87debcdcc193b7db66	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 60/163 (36.8%); all four pericyte markers: 16/163 (9.8%); Acta2/Tagln/Myh11: 149/163 (91.4%); Cnn1/Entpd1: 27/163 (16.6%); Plp1/Cnp: 0/163 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/163 (0.6%); Pecam1/Cdh5: 0/163 (0.0%); Ptprc plus a listed subtype marker: 0/163 (0.0%)	SS: n=29; detection/mean Acta2 100.0%/107, Tagln 100.0%/67.1, Myh11 89.7%/15.6, Cnn1 31.0%/1.62, Entpd1 24.1%/0.851; pericyte pair 24.1%, contractile triple 89.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=103; detection/mean Acta2 100.0%/117, Tagln 99.0%/88.8, Myh11 100.0%/15.2, Cnn1 34.0%/1.25, Entpd1 51.5%/0.789; pericyte pair 41.7%, contractile triple 99.0%, Schwann pair 0.0%, fibroblast pair 1.0% | D7: n=12 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/106, Tagln 100.0%/39.9, Myh11 91.7%/11.9, Cnn1 33.3%/1.91, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 91.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=19 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 78.9%/80.1, Tagln 84.2%/36.7, Myh11 52.6%/9.41, Cnn1 26.3%/1.31, Entpd1 5.3%/0.0987; pericyte pair 52.6%, contractile triple 52.6%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2447; median mitochondrial fraction 0.0488; predicted doublets 0/163; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=8; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.479190+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
9	neighbors_10	9	878	pericyte	pericyte	supported	Kcnj8: 74.0% detected, mean 9.66 versus rest 5.63; Abcc9: 68.9% detected, mean 4.4 versus rest 3.71; Colec11: 94.0% detected, mean 24.1 versus rest 4.75; Vtn: 89.1% detected, mean 19.9 versus rest 5.04	Other programs remain visible: same-cell pericyte pair and contractile triple 40.0%; pericyte and fibroblast pairs 8.1%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	6f0d23163c11410272bc0f297acc728030b9814827f8e40e10611e9c81e842c9	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 828/878 (94.3%); all four pericyte markers: 469/878 (53.4%); Acta2/Tagln/Myh11: 381/878 (43.4%); Cnn1/Entpd1: 15/878 (1.7%); Plp1/Cnp: 2/878 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 95/878 (10.8%); Pecam1/Cdh5: 0/878 (0.0%); Ptprc plus a listed subtype marker: 0/878 (0.0%)	SS: n=76; detection/mean Kcnj8 60.5%/5.77, Abcc9 46.1%/1.88, Colec11 82.9%/20.8, Vtn 73.7%/24.8; pericyte pair 80.3%, contractile triple 69.7%, Schwann pair 0.0%, fibroblast pair 15.8% | D3: n=90; detection/mean Kcnj8 60.0%/2.6, Abcc9 81.1%/3.66, Colec11 92.2%/12.7, Vtn 93.3%/17.7; pericyte pair 95.6%, contractile triple 85.6%, Schwann pair 1.1%, fibroblast pair 17.8% | D7: n=506; detection/mean Kcnj8 79.2%/11.6, Abcc9 75.7%/5.32, Colec11 95.3%/23.9, Vtn 88.5%/14.9; pericyte pair 95.7%, contractile triple 31.0%, Schwann pair 0.2%, fibroblast pair 10.9% | D42: n=206; detection/mean Kcnj8 72.3%/9.38, Abcc9 55.3%/3.38, Colec11 95.6%/30.6, Vtn 94.2%/31.2; pericyte pair 95.6%, contractile triple 45.6%, Schwann pair 0.0%, fibroblast pair 5.8%	median detected genes 1959.5; median mitochondrial fraction 0.0309; predicted doublets 3/878; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=9; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.501760+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
10	neighbors_10	10	994	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 260 versus rest 105; Tagln: 100.0% detected, mean 201 versus rest 65.7; Myh11: 100.0% detected, mean 31.7 versus rest 14.2; Cnn1: 98.1% detected, mean 7.1 versus rest 1.87; Entpd1: 75.2% detected, mean 1.39 versus rest 0.608	Other programs remain visible: same-cell pericyte pair and contractile triple 5.4%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.3%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	4818c19c63c607a682100c3618aec88c09a4b8bf7839f15627502082cfb06a9a	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 54/994 (5.4%); all four pericyte markers: 5/994 (0.5%); Acta2/Tagln/Myh11: 994/994 (100.0%); Cnn1/Entpd1: 739/994 (74.3%); Plp1/Cnp: 3/994 (0.3%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/994 (0.1%); Pecam1/Cdh5: 0/994 (0.0%); Ptprc plus a listed subtype marker: 0/994 (0.0%)	SS: n=19 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/188, Tagln 100.0%/146, Myh11 100.0%/34.4, Cnn1 100.0%/9.77, Entpd1 42.1%/1.42; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=975; detection/mean Acta2 100.0%/261, Tagln 100.0%/202, Myh11 100.0%/31.7, Cnn1 98.1%/7.05, Entpd1 75.8%/1.39; pericyte pair 5.5%, contractile triple 100.0%, Schwann pair 0.3%, fibroblast pair 0.1% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 3143.5; median mitochondrial fraction 0.0845; predicted doublets 0/994; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=10; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.512770+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
11	neighbors_10	11	1601	pericyte	pericyte	supported	Kcnj8: 93.1% detected, mean 24.1 versus rest 3.95; Abcc9: 96.8% detected, mean 21.3 versus rest 1.92; Colec11: 92.8% detected, mean 20.6 versus rest 4.21; Vtn: 92.4% detected, mean 17.7 versus rest 4.57	Other programs remain visible: same-cell pericyte pair and contractile triple 22.2%; pericyte and fibroblast pairs 0.9%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e1c886b4505a1c69630cdbdc64bc650c55827a13b94a578a7a2ae695cc8b790c	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1573/1601 (98.3%); all four pericyte markers: 1327/1601 (82.9%); Acta2/Tagln/Myh11: 364/1601 (22.7%); Cnn1/Entpd1: 0/1601 (0.0%); Plp1/Cnp: 2/1601 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 15/1601 (0.9%); Pecam1/Cdh5: 0/1601 (0.0%); Ptprc plus a listed subtype marker: 0/1601 (0.0%)	SS: n=23; detection/mean Kcnj8 95.7%/29, Abcc9 95.7%/14.4, Colec11 95.7%/20, Vtn 91.3%/21.7; pericyte pair 100.0%, contractile triple 13.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1578; detection/mean Kcnj8 93.0%/24, Abcc9 96.8%/21.4, Colec11 92.7%/20.6, Vtn 92.5%/17.7; pericyte pair 98.2%, contractile triple 22.9%, Schwann pair 0.1%, fibroblast pair 1.0% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 1744; median mitochondrial fraction 0.0443; predicted doublets 0/1601; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=11; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.523362+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
12	neighbors_10	12	98	unassigned	unassigned	mixed	Kcnj8: 98.0% detected, mean 7.22 versus rest 5.83; Abcc9: 99.0% detected, mean 7.01 versus rest 3.72; Colec11: 94.9% detected, mean 6.04 versus rest 5.74; Vtn: 93.9% detected, mean 5.04 versus rest 5.81; Myh11: 100.0% detected, mean 18.4 versus rest 15.2; Cnn1: 72.4% detected, mean 2.66 versus rest 2.17; Entpd1: 62.2% detected, mean 0.991 versus rest 0.651; Pdgfra: 0.0% detected, mean 0 versus rest 0.0151; Lum: 2.0% detected, mean 0.0201 versus rest 0.438; Dcn: 11.2% detected, mean 0.0961 versus rest 1.62; Cd34: 3.1% detected, mean 0.0208 versus rest 0.0755	Other programs remain visible: same-cell pericyte pair and contractile triple 99.0%; pericyte and fibroblast pairs 2.0%; Schwann pair and contractile triple 1.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Strong pericyte and VSMC-associated programs occur in the same cells: all four pericyte markers commonly coincide with Acta2/Tagln/Myh11, and Cnn1/Entpd1 coexpression is substantial. Elevated doublet flags and complexity add concern, but do not prove doublets. Pericyte contractile overlap alone would not justify exclusion; the combined unusually strong dual signature leaves mural identity unresolved. Retain all cells in composition denominators, label unassigned, and exclude this cluster from supported-pericyte contrasts. 98 cells: 89 express all four pericyte markers; all 98 express Acta2/Tagln/Myh11; 49 express Cnn1/Entpd1. Eleven Scrublet flags are retained. This is a variant-specific unresolved mixed group, not a transferred primary label.	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	83d3318a71fd729e5cffc6184e9a4dff5d8c047fd1b77b6fecd60255d81284db	SCP002-A001	accepted_versioned_annotation_decision	M	at least two of Kcnj8/Abcc9/Colec11/Vtn: 97/98 (99.0%); all four pericyte markers: 89/98 (90.8%); Acta2/Tagln/Myh11: 98/98 (100.0%); Cnn1/Entpd1: 49/98 (50.0%); Plp1/Cnp: 1/98 (1.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 2/98 (2.0%); Pecam1/Cdh5: 0/98 (0.0%); Ptprc plus a listed subtype marker: 0/98 (0.0%)	SS: n=11 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/10.3, Abcc9 100.0%/6.47, Colec11 100.0%/8.04, Vtn 100.0%/7.96, Myh11 100.0%/18.9, Cnn1 72.7%/2.55, Entpd1 45.5%/0.812, Pdgfra 0.0%/0, Lum 0.0%/0, Dcn 0.0%/0, Cd34 0.0%/0; pericyte pair 100.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=87; detection/mean Kcnj8 97.7%/6.83, Abcc9 98.9%/7.07, Colec11 94.3%/5.79, Vtn 93.1%/4.67, Myh11 100.0%/18.3, Cnn1 72.4%/2.68, Entpd1 64.4%/1.01, Pdgfra 0.0%/0, Lum 2.3%/0.0226, Dcn 12.6%/0.108, Cd34 3.4%/0.0234; pericyte pair 98.9%, contractile triple 100.0%, Schwann pair 1.1%, fibroblast pair 2.3% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 3662; median mitochondrial fraction 0.0671; predicted doublets 11/98; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=12; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.534669+00:00	mixed	Strong pericyte and VSMC-associated programs occur in the same cells: all four pericyte markers commonly coincide with Acta2/Tagln/Myh11, and Cnn1/Entpd1 coexpression is substantial. Elevated doublet flags and complexity add concern, but do not prove doublets. Pericyte contractile overlap alone would not justify exclusion; the combined unusually strong dual signature leaves mural identity unresolved. Retain all cells in composition denominators, label unassigned, and exclude this cluster from supported-pericyte contrasts. 98 cells: 89 express all four pericyte markers; all 98 express Acta2/Tagln/Myh11; 49 express Cnn1/Entpd1. Eleven Scrublet flags are retained. This is a variant-specific unresolved mixed group, not a transferred primary label.	proposal_uncertainty_retained
13	neighbors_10	13	557	pericyte	pericyte	supported	Kcnj8: 76.7% detected, mean 5.32 versus rest 5.85; Abcc9: 86.0% detected, mean 5.13 versus rest 3.69; Colec11: 69.7% detected, mean 4.83 versus rest 5.77; Vtn: 84.6% detected, mean 4.63 versus rest 5.84	Other programs remain visible: same-cell pericyte pair and contractile triple 60.0%; pericyte and fibroblast pairs 11.5%; Schwann pair and contractile triple 0.5%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	c63a3de7f4062b2d4f6bfac0c6c3d7746ae8881dab3fbdcb5b094a08549128ae	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 489/557 (87.8%); all four pericyte markers: 322/557 (57.8%); Acta2/Tagln/Myh11: 373/557 (67.0%); Cnn1/Entpd1: 14/557 (2.5%); Plp1/Cnp: 5/557 (0.9%); at least two of Pdgfra/Lum/Dcn/Cd34: 67/557 (12.0%); Pecam1/Cdh5: 0/557 (0.0%); Ptprc plus a listed subtype marker: 0/557 (0.0%)	SS: n=6 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 50.0%/10.1, Abcc9 66.7%/4.33, Colec11 66.7%/10, Vtn 100.0%/21.9; pericyte pair 66.7%, contractile triple 50.0%, Schwann pair 0.0%, fibroblast pair 16.7% | D3: n=517; detection/mean Kcnj8 77.2%/5.15, Abcc9 87.6%/5.26, Colec11 70.0%/4.73, Vtn 85.5%/4.34; pericyte pair 88.6%, contractile triple 68.1%, Schwann pair 0.8%, fibroblast pair 12.2% | D7: n=29; detection/mean Kcnj8 69.0%/5.68, Abcc9 58.6%/2.07, Colec11 62.1%/4.58, Vtn 65.5%/4.65; pericyte pair 75.9%, contractile triple 62.1%, Schwann pair 3.4%, fibroblast pair 10.3% | D42: n=5 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/15, Abcc9 100.0%/11, Colec11 80.0%/9.96, Vtn 80.0%/14.2; pericyte pair 100.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 4420; median mitochondrial fraction 0.0358; predicted doublets 0/557; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=13; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.554135+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
14	neighbors_10	14	254	fibroblast	fibroblast	supported	Pdgfra: 58.3% detected, mean 0.853 versus rest 0.00242; Lum: 96.1% detected, mean 25.5 versus rest 0.0569; Dcn: 99.6% detected, mean 70.6 versus rest 0.57; Cd34: 81.9% detected, mean 3.39 versus rest 0.0252	Other programs remain visible: same-cell pericyte pair and contractile triple 2.4%; pericyte and fibroblast pairs 7.5%; Schwann pair and contractile triple 1.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	ad76ec777d98dba2bdb0ed0396bb20c6950d0a93d54d154a7e2d55fdf0b304f3	SCP002-A001	accepted_versioned_annotation_decision	F	at least two of Kcnj8/Abcc9/Colec11/Vtn: 19/254 (7.5%); all four pericyte markers: 4/254 (1.6%); Acta2/Tagln/Myh11: 47/254 (18.5%); Cnn1/Entpd1: 3/254 (1.2%); Plp1/Cnp: 3/254 (1.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 253/254 (99.6%); Pecam1/Cdh5: 0/254 (0.0%); Ptprc plus a listed subtype marker: 0/254 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=82; detection/mean Pdgfra 76.8%/0.923, Lum 92.7%/6.54, Dcn 98.8%/21, Cd34 74.4%/1.32; pericyte pair 14.6%, contractile triple 43.9%, Schwann pair 1.2%, fibroblast pair 98.8% | D7: n=165; detection/mean Pdgfra 49.1%/0.772, Lum 97.6%/33.2, Dcn 100.0%/89.4, Cd34 85.5%/4.31; pericyte pair 4.2%, contractile triple 6.7%, Schwann pair 1.2%, fibroblast pair 100.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Pdgfra 57.1%/1.96, Lum 100.0%/66.5, Dcn 100.0%/206, Cd34 85.7%/6.26; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 100.0%	median detected genes 3424.5; median mitochondrial fraction 0.0239; predicted doublets 0/254; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_10, cluster=14; source annotation_evidence/markers_neighbors_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.569210+00:00	supported	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	supported_broad_identity_retained
0	neighbors_30	0	2917	VSMC	VSMC	supported	Acta2: 99.8% detected, mean 156 versus rest 105; Tagln: 99.6% detected, mean 96.7 versus rest 68.8; Myh11: 97.9% detected, mean 23 versus rest 13.7; Cnn1: 51.1% detected, mean 3.75 versus rest 1.85; Entpd1: 29.7% detected, mean 0.805 versus rest 0.622	Other programs remain visible: same-cell pericyte pair and contractile triple 7.2%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	f816f3182492e4247db0ed2d95774a248bc0aa53c1ae2a3f1db0b7d4b81ec243	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 237/2917 (8.1%); all four pericyte markers: 14/2917 (0.5%); Acta2/Tagln/Myh11: 2845/2917 (97.5%); Cnn1/Entpd1: 552/2917 (18.9%); Plp1/Cnp: 3/2917 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2917 (0.0%); Pecam1/Cdh5: 0/2917 (0.0%); Ptprc plus a listed subtype marker: 0/2917 (0.0%)	SS: n=2864; detection/mean Acta2 99.8%/155, Tagln 99.6%/96.4, Myh11 98.0%/22.9, Cnn1 51.3%/3.74, Entpd1 29.6%/0.798; pericyte pair 8.2%, contractile triple 97.7%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=41; detection/mean Acta2 100.0%/179, Tagln 100.0%/122, Myh11 87.8%/26.9, Cnn1 43.9%/4.19, Entpd1 34.1%/1.33; pericyte pair 7.3%, contractile triple 87.8%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=9 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/127, Tagln 100.0%/98.1, Myh11 100.0%/43.9, Cnn1 55.6%/5.88, Entpd1 22.2%/0.577; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=3 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/118, Tagln 100.0%/32.7, Myh11 100.0%/24.8, Cnn1 0.0%/0, Entpd1 33.3%/0.926; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1816; median mitochondrial fraction 0.0607; predicted doublets 8/2917; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_30, cluster=0; source annotation_evidence/markers_neighbors_30/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.589050+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
1	neighbors_30	1	1398	pericyte	pericyte	supported	Kcnj8: 87.6% detected, mean 30.8 versus rest 3.61; Abcc9: 81.1% detected, mean 12.3 versus rest 2.98; Colec11: 90.8% detected, mean 22.7 versus rest 4.23; Vtn: 90.4% detected, mean 25.2 versus rest 4.07	Other programs remain visible: same-cell pericyte pair and contractile triple 13.0%; pericyte and fibroblast pairs 0.3%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	619b31afd9c380fc8e20d5ce1f0503fcc7f1331b4195adc270d6aeb18874e32a	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1334/1398 (95.4%); all four pericyte markers: 948/1398 (67.8%); Acta2/Tagln/Myh11: 207/1398 (14.8%); Cnn1/Entpd1: 0/1398 (0.0%); Plp1/Cnp: 3/1398 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 5/1398 (0.4%); Pecam1/Cdh5: 0/1398 (0.0%); Ptprc plus a listed subtype marker: 0/1398 (0.0%)	SS: n=385; detection/mean Kcnj8 91.2%/25.6, Abcc9 83.1%/11.9, Colec11 93.5%/21.1, Vtn 94.0%/25.5; pericyte pair 97.7%, contractile triple 15.8%, Schwann pair 0.0%, fibroblast pair 0.3% | D3: n=57; detection/mean Kcnj8 75.4%/25.4, Abcc9 57.9%/14.3, Colec11 71.9%/19.3, Vtn 75.4%/19.3; pericyte pair 84.2%, contractile triple 10.5%, Schwann pair 0.0%, fibroblast pair 1.8% | D7: n=229; detection/mean Kcnj8 85.2%/32.8, Abcc9 78.2%/11.8, Colec11 93.0%/25.7, Vtn 90.0%/29.6; pericyte pair 95.6%, contractile triple 10.5%, Schwann pair 0.0%, fibroblast pair 0.9% | D42: n=727; detection/mean Kcnj8 87.5%/33.5, Abcc9 82.8%/12.5, Colec11 90.2%/22.8, Vtn 89.8%/24.1; pericyte pair 95.0%, contractile triple 16.0%, Schwann pair 0.4%, fibroblast pair 0.1%	median detected genes 1224; median mitochondrial fraction 0.0311; predicted doublets 5/1398; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_30, cluster=1; source annotation_evidence/markers_neighbors_30/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.608562+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
2	neighbors_30	2	1534	pericyte	pericyte	supported	Kcnj8: 75.0% detected, mean 9.04 versus rest 5.52; Abcc9: 75.0% detected, mean 4.82 versus rest 3.63; Colec11: 83.4% detected, mean 16.7 versus rest 4.66; Vtn: 85.9% detected, mean 14.6 versus rest 4.93	Other programs remain visible: same-cell pericyte pair and contractile triple 44.3%; pericyte and fibroblast pairs 9.3%; Schwann pair and contractile triple 0.3%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	b61bd6b16a157771eaa331100a03713a0f3303ee179199800e0e03309eb1c246	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1384/1534 (90.2%); all four pericyte markers: 850/1534 (55.4%); Acta2/Tagln/Myh11: 760/1534 (49.5%); Cnn1/Entpd1: 28/1534 (1.8%); Plp1/Cnp: 7/1534 (0.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 199/1534 (13.0%); Pecam1/Cdh5: 0/1534 (0.0%); Ptprc plus a listed subtype marker: 0/1534 (0.0%)	SS: n=83; detection/mean Kcnj8 59.0%/6.02, Abcc9 47.0%/2.03, Colec11 80.7%/19.8, Vtn 75.9%/24.3; pericyte pair 78.3%, contractile triple 67.5%, Schwann pair 0.0%, fibroblast pair 15.7% | D3: n=633; detection/mean Kcnj8 72.0%/4.56, Abcc9 83.6%/4.75, Colec11 70.6%/5.54, Vtn 83.1%/6.17; pericyte pair 86.3%, contractile triple 68.6%, Schwann pair 0.8%, fibroblast pair 17.2% | D7: n=589; detection/mean Kcnj8 80.6%/13.7, Abcc9 76.2%/5.65, Colec11 92.9%/23.2, Vtn 87.3%/16.1; pericyte pair 94.2%, contractile triple 29.5%, Schwann pair 0.3%, fibroblast pair 10.9% | D42: n=229; detection/mean Kcnj8 74.2%/10.6, Abcc9 58.5%/3.89, Colec11 95.2%/29.8, Vtn 93.4%/30.7; pericyte pair 95.2%, contractile triple 41.9%, Schwann pair 0.0%, fibroblast pair 5.7%	median detected genes 2399; median mitochondrial fraction 0.0326; predicted doublets 3/1534; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_30, cluster=2; source annotation_evidence/markers_neighbors_30/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.628162+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
3	neighbors_30	3	2262	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 123 versus rest 112; Tagln: 98.9% detected, mean 85 versus rest 71.8; Myh11: 95.1% detected, mean 15.9 versus rest 15.2; Cnn1: 23.0% detected, mean 0.926 versus rest 2.36; Entpd1: 38.9% detected, mean 0.86 versus rest 0.622	Other programs remain visible: same-cell pericyte pair and contractile triple 30.2%; pericyte and fibroblast pairs 0.1%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	9b388d5c51a31b060be4dab66e69d12212ed5da3418c98724a3d901d7c966e93	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 757/2262 (33.5%); all four pericyte markers: 153/2262 (6.8%); Acta2/Tagln/Myh11: 2143/2262 (94.7%); Cnn1/Entpd1: 333/2262 (14.7%); Plp1/Cnp: 4/2262 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 3/2262 (0.1%); Pecam1/Cdh5: 0/2262 (0.0%); Ptprc plus a listed subtype marker: 0/2262 (0.0%)	SS: n=18 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/92, Tagln 77.8%/47.7, Myh11 77.8%/10.7, Cnn1 16.7%/1.06, Entpd1 5.6%/0.0881; pericyte pair 27.8%, contractile triple 66.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=2239; detection/mean Acta2 99.9%/123, Tagln 99.2%/85.3, Myh11 95.3%/16, Cnn1 23.1%/0.927, Entpd1 39.2%/0.865; pericyte pair 33.5%, contractile triple 95.0%, Schwann pair 0.2%, fibroblast pair 0.1% | D7: n=5 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/113, Tagln 60.0%/69.8, Myh11 100.0%/9.5, Cnn1 0.0%/0, Entpd1 20.0%/0.959; pericyte pair 60.0%, contractile triple 60.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 2232.5; median mitochondrial fraction 0.0582; predicted doublets 1/2262; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_30, cluster=3; source annotation_evidence/markers_neighbors_30/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.643471+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
4	neighbors_30	4	643	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 292 versus rest 107; Tagln: 100.0% detected, mean 233 versus rest 67.3; Myh11: 100.0% detected, mean 34.5 versus rest 14.5; Cnn1: 99.2% detected, mean 8.41 versus rest 1.93; Entpd1: 76.0% detected, mean 1.38 versus rest 0.625	Other programs remain visible: same-cell pericyte pair and contractile triple 6.1%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.3%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	33ffd5d227b80fb13700bd5cadbb97347f9cd16a14789009797e29763b2debba	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 39/643 (6.1%); all four pericyte markers: 6/643 (0.9%); Acta2/Tagln/Myh11: 643/643 (100.0%); Cnn1/Entpd1: 488/643 (75.9%); Plp1/Cnp: 2/643 (0.3%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/643 (0.2%); Pecam1/Cdh5: 0/643 (0.0%); Ptprc plus a listed subtype marker: 0/643 (0.0%)	SS: n=20; detection/mean Acta2 100.0%/197, Tagln 100.0%/159, Myh11 100.0%/32.6, Cnn1 90.0%/8.97, Entpd1 35.0%/1.23; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=622; detection/mean Acta2 100.0%/295, Tagln 100.0%/236, Myh11 100.0%/34.6, Cnn1 99.5%/8.37, Entpd1 77.5%/1.39; pericyte pair 6.3%, contractile triple 100.0%, Schwann pair 0.3%, fibroblast pair 0.2% | D7: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/317, Tagln 100.0%/185, Myh11 100.0%/19.8, Cnn1 100.0%/19.8, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 3248; median mitochondrial fraction 0.0833; predicted doublets 0/643; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_30, cluster=4; source annotation_evidence/markers_neighbors_30/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.658765+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
5	neighbors_30	5	3067	VSMC	VSMC	supported	Acta2: 99.3% detected, mean 142 versus rest 108; Tagln: 98.4% detected, mean 71.9 versus rest 73.9; Myh11: 94.4% detected, mean 21.2 versus rest 14; Cnn1: 44.3% detected, mean 3.24 versus rest 1.94; Entpd1: 24.0% detected, mean 0.778 versus rest 0.626	Other programs remain visible: same-cell pericyte pair and contractile triple 8.7%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	c10445d61e7dabd161815e12fd52c4d58353efe476024ceaa44d391ee85158e9	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 342/3067 (11.2%); all four pericyte markers: 29/3067 (0.9%); Acta2/Tagln/Myh11: 2872/3067 (93.6%); Cnn1/Entpd1: 448/3067 (14.6%); Plp1/Cnp: 1/3067 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/3067 (0.0%); Pecam1/Cdh5: 0/3067 (0.0%); Ptprc plus a listed subtype marker: 0/3067 (0.0%)	SS: n=30; detection/mean Acta2 100.0%/117, Tagln 96.7%/66.1, Myh11 80.0%/14.2, Cnn1 23.3%/1.35, Entpd1 6.7%/0.221; pericyte pair 20.0%, contractile triple 76.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=11 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/168, Tagln 100.0%/120, Myh11 63.6%/26.3, Cnn1 27.3%/3.82, Entpd1 18.2%/0.796; pericyte pair 0.0%, contractile triple 63.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=1430; detection/mean Acta2 98.6%/128, Tagln 97.4%/62.9, Myh11 93.8%/19.8, Cnn1 41.9%/3.12, Entpd1 21.7%/0.741; pericyte pair 11.5%, contractile triple 92.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1596; detection/mean Acta2 99.9%/154, Tagln 99.2%/79.7, Myh11 95.4%/22.6, Cnn1 46.9%/3.39, Entpd1 26.3%/0.822; pericyte pair 10.7%, contractile triple 95.0%, Schwann pair 0.1%, fibroblast pair 0.0%	median detected genes 1492; median mitochondrial fraction 0.0645; predicted doublets 6/3067; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_30, cluster=5; source annotation_evidence/markers_neighbors_30/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.678620+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
6	neighbors_30	6	432	Schwann	Schwann	supported	Plp1: 96.8% detected, mean 23 versus rest 0.0544; Cnp: 88.9% detected, mean 13.4 versus rest 0.106	Other programs remain visible: same-cell pericyte pair and contractile triple 1.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 13.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e6f997da9513413875ba350696d03eb9becd30a955298bb06266857351585789	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 14/432 (3.2%); all four pericyte markers: 3/432 (0.7%); Acta2/Tagln/Myh11: 64/432 (14.8%); Cnn1/Entpd1: 10/432 (2.3%); Plp1/Cnp: 378/432 (87.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/432 (0.0%); Pecam1/Cdh5: 0/432 (0.0%); Ptprc plus a listed subtype marker: 0/432 (0.0%)	SS: n=121; detection/mean Plp1 95.0%/22, Cnp 90.1%/18.5; pericyte pair 1.7%, contractile triple 9.1%, Schwann pair 86.8%, fibroblast pair 0.0% | D3: n=215; detection/mean Plp1 97.7%/20.1, Cnp 87.0%/8.13; pericyte pair 5.6%, contractile triple 24.7%, Schwann pair 86.5%, fibroblast pair 0.0% | D7: n=35; detection/mean Plp1 94.3%/31.6, Cnp 85.7%/15.4; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 82.9%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1888; median mitochondrial fraction 0.0288; predicted doublets 4/432; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_30, cluster=6; source annotation_evidence/markers_neighbors_30/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.698268+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
7	neighbors_30	7	2879	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 154 versus rest 106; Tagln: 100.0% detected, mean 112 versus rest 65.7; Myh11: 99.7% detected, mean 20 versus rest 14.3; Cnn1: 56.5% detected, mean 2.34 versus rest 2.14; Entpd1: 56.4% detected, mean 1.15 versus rest 0.553	Other programs remain visible: same-cell pericyte pair and contractile triple 11.2%; pericyte and fibroblast pairs 0.1%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	413d515527c44b72b9aa95624b0485701e65ac5d458151138a5d6307aa54c6f5	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 324/2879 (11.3%); all four pericyte markers: 93/2879 (3.2%); Acta2/Tagln/Myh11: 2870/2879 (99.7%); Cnn1/Entpd1: 1070/2879 (37.2%); Plp1/Cnp: 2/2879 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 4/2879 (0.1%); Pecam1/Cdh5: 0/2879 (0.0%); Ptprc plus a listed subtype marker: 0/2879 (0.0%)	SS: n=30; detection/mean Acta2 100.0%/131, Tagln 100.0%/87.4, Myh11 100.0%/23.9, Cnn1 73.3%/4.33, Entpd1 40.0%/0.824; pericyte pair 30.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=2849; detection/mean Acta2 100.0%/154, Tagln 100.0%/113, Myh11 99.7%/19.9, Cnn1 56.4%/2.32, Entpd1 56.6%/1.15; pericyte pair 11.1%, contractile triple 99.7%, Schwann pair 0.1%, fibroblast pair 0.1% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2578; median mitochondrial fraction 0.0692; predicted doublets 8/2879; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_30, cluster=7; source annotation_evidence/markers_neighbors_30/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.708999+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
8	neighbors_30	8	1599	pericyte	pericyte	supported	Kcnj8: 92.4% detected, mean 23.8 versus rest 3.98; Abcc9: 96.8% detected, mean 21.3 versus rest 1.93; Colec11: 92.7% detected, mean 20.6 versus rest 4.21; Vtn: 92.4% detected, mean 17.6 versus rest 4.58	Other programs remain visible: same-cell pericyte pair and contractile triple 23.0%; pericyte and fibroblast pairs 1.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	9c41cd8e30051dfe9a7ec463d728330727f9e10380b60f4aff18c7bcceb02a4b	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1568/1599 (98.1%); all four pericyte markers: 1319/1599 (82.5%); Acta2/Tagln/Myh11: 377/1599 (23.6%); Cnn1/Entpd1: 0/1599 (0.0%); Plp1/Cnp: 2/1599 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 16/1599 (1.0%); Pecam1/Cdh5: 0/1599 (0.0%); Ptprc plus a listed subtype marker: 0/1599 (0.0%)	SS: n=15 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 80.0%/23.8, Abcc9 93.3%/14.4, Colec11 86.7%/22, Vtn 80.0%/20.9; pericyte pair 93.3%, contractile triple 20.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1584; detection/mean Kcnj8 92.5%/23.8, Abcc9 96.8%/21.3, Colec11 92.7%/20.5, Vtn 92.6%/17.6; pericyte pair 98.1%, contractile triple 23.6%, Schwann pair 0.1%, fibroblast pair 1.0% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 1749; median mitochondrial fraction 0.0443; predicted doublets 1/1599; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_30, cluster=8; source annotation_evidence/markers_neighbors_30/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.719447+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
9	neighbors_30	9	159	VSMC	VSMC	supported	Acta2: 98.7% detected, mean 121 versus rest 114; Tagln: 99.4% detected, mean 78.5 versus rest 73.5; Myh11: 94.3% detected, mean 15.9 versus rest 15.3; Cnn1: 34.6% detected, mean 1.48 versus rest 2.18; Entpd1: 32.1% detected, mean 0.608 versus rest 0.654	Other programs remain visible: same-cell pericyte pair and contractile triple 20.8%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	8027dc41cbfcacda339691a9275cfad41b85f049280b47e3a10efbde6d20181a	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 37/159 (23.3%); all four pericyte markers: 2/159 (1.3%); Acta2/Tagln/Myh11: 150/159 (94.3%); Cnn1/Entpd1: 25/159 (15.7%); Plp1/Cnp: 0/159 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/159 (0.0%); Pecam1/Cdh5: 0/159 (0.0%); Ptprc plus a listed subtype marker: 0/159 (0.0%)	SS: n=28; detection/mean Acta2 100.0%/111, Tagln 100.0%/69.7, Myh11 96.4%/16.8, Cnn1 28.6%/1.46, Entpd1 21.4%/0.533; pericyte pair 14.3%, contractile triple 96.4%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=77; detection/mean Acta2 100.0%/131, Tagln 100.0%/101, Myh11 100.0%/17.1, Cnn1 42.9%/1.63, Entpd1 54.5%/0.88; pericyte pair 28.6%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=17 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 94.1%/98.4, Tagln 94.1%/40.4, Myh11 88.2%/11, Cnn1 29.4%/1.6, Entpd1 0.0%/0; pericyte pair 5.9%, contractile triple 88.2%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=37; detection/mean Acta2 97.3%/116, Tagln 100.0%/55.3, Myh11 83.8%/14.8, Cnn1 24.3%/1.14, Entpd1 8.1%/0.38; pericyte pair 27.0%, contractile triple 83.8%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1989; median mitochondrial fraction 0.0503; predicted doublets 0/159; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_30, cluster=9; source annotation_evidence/markers_neighbors_30/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.739087+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
10	neighbors_30	10	217	fibroblast	fibroblast	supported	Pdgfra: 53.9% detected, mean 0.848 versus rest 0.00436; Lum: 96.8% detected, mean 28.5 versus rest 0.0748; Dcn: 99.5% detected, mean 77.5 versus rest 0.635; Cd34: 82.9% detected, mean 3.51 versus rest 0.0311	Other programs remain visible: same-cell pericyte pair and contractile triple 1.8%; pericyte and fibroblast pairs 5.5%; Schwann pair and contractile triple 1.4%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	f820d2ee1f9f5d622351394243d73193cddfbd4aa7a1f51912deb78c2cacda51	SCP002-A001	accepted_versioned_annotation_decision	F	at least two of Kcnj8/Abcc9/Colec11/Vtn: 12/217 (5.5%); all four pericyte markers: 1/217 (0.5%); Acta2/Tagln/Myh11: 33/217 (15.2%); Cnn1/Entpd1: 3/217 (1.4%); Plp1/Cnp: 3/217 (1.4%); at least two of Pdgfra/Lum/Dcn/Cd34: 216/217 (99.5%); Pecam1/Cdh5: 0/217 (0.0%); Ptprc plus a listed subtype marker: 0/217 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=51; detection/mean Pdgfra 70.6%/0.999, Lum 94.1%/7.86, Dcn 98.0%/23.7, Cd34 74.5%/1.45; pericyte pair 11.8%, contractile triple 45.1%, Schwann pair 2.0%, fibroblast pair 98.0% | D7: n=159; detection/mean Pdgfra 48.4%/0.75, Lum 97.5%/33.4, Dcn 100.0%/89, Cd34 85.5%/4.05; pericyte pair 3.8%, contractile triple 6.3%, Schwann pair 1.3%, fibroblast pair 100.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Pdgfra 57.1%/1.96, Lum 100.0%/66.5, Dcn 100.0%/206, Cd34 85.7%/6.26; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 100.0%	median detected genes 3307; median mitochondrial fraction 0.0244; predicted doublets 0/217; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=neighbors_30, cluster=10; source annotation_evidence/markers_neighbors_30/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.754230+00:00	supported	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	supported_broad_identity_retained
0	pcs_20	0	733	VSMC	unassigned	uncertain	Acta2: 97.7% detected, mean 103 versus rest 114; Tagln: 92.5% detected, mean 58.1 versus rest 74.2; Myh11: 85.7% detected, mean 13.7 versus rest 15.3; Cnn1: 13.2% detected, mean 0.658 versus rest 2.24; Entpd1: 16.0% detected, mean 0.491 versus rest 0.661	Other programs remain visible: same-cell pericyte pair and contractile triple 23.9%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Separate review retains VSMC as a plausible proposal but leaves the final identity unassigned. The cluster has a dominant contractile program (81.7% Acta2/Tagln/Myh11 conjunction), yet pericyte-marker conjunctions remain substantial (37.2% at least two markers; 8.3% all four), with relatively weak Cnn1/Entpd1 context (2.9% conjoint detection). Almost all cells are SS (711/733); the other library subsets are too small to resolve heterogeneity. The shared contractile program does not uniquely distinguish these mural identities. This is a combined evidence judgment, not a new single-marker cutoff or a claim that the cluster is pericytes. Preserve all cells in composition denominators; do not include this uncertain group in supported-pericyte contrasts.	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	501bd0e31e52e1c20e531839c54f58e254bbfaa7450e024b5f63d49d6c7fc023	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 273/733 (37.2%); all four pericyte markers: 61/733 (8.3%); Acta2/Tagln/Myh11: 599/733 (81.7%); Cnn1/Entpd1: 21/733 (2.9%); Plp1/Cnp: 1/733 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/733 (0.0%); Pecam1/Cdh5: 0/733 (0.0%); Ptprc plus a listed subtype marker: 0/733 (0.0%)	SS: n=711; detection/mean Acta2 97.9%/104, Tagln 92.7%/58.8, Myh11 86.4%/13.8, Cnn1 13.5%/0.675, Entpd1 16.5%/0.506; pericyte pair 36.8%, contractile triple 82.3%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=13 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/95, Tagln 84.6%/49.2, Myh11 69.2%/8.89, Cnn1 7.7%/0.231, Entpd1 0.0%/0; pericyte pair 46.2%, contractile triple 69.2%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 71.4%/47.4, Tagln 85.7%/18.4, Myh11 57.1%/7.63, Cnn1 0.0%/0, Entpd1 0.0%/0; pericyte pair 71.4%, contractile triple 57.1%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=2 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/99, Tagln 100.0%/31, Myh11 50.0%/7.78, Cnn1 0.0%/0, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 50.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1535; median mitochondrial fraction 0.0433; predicted doublets 0/733; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_20, cluster=0; source annotation_evidence/markers_pcs_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.774407+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	additional_boundary_uncertainty
1	pcs_20	1	2087	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 130 versus rest 112; Tagln: 99.0% detected, mean 90.4 versus rest 71.2; Myh11: 95.8% detected, mean 17 versus rest 15; Cnn1: 29.3% detected, mean 1.26 versus rest 2.3; Entpd1: 41.0% detected, mean 0.883 versus rest 0.621	Other programs remain visible: same-cell pericyte pair and contractile triple 34.4%; pericyte and fibroblast pairs 0.2%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	ab7c4ceac48e33ea7347fa8f02b805436d4aed0bc46a33ad0838fa6f6f021d4e	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 774/2087 (37.1%); all four pericyte markers: 230/2087 (11.0%); Acta2/Tagln/Myh11: 1992/2087 (95.4%); Cnn1/Entpd1: 401/2087 (19.2%); Plp1/Cnp: 4/2087 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 6/2087 (0.3%); Pecam1/Cdh5: 0/2087 (0.0%); Ptprc plus a listed subtype marker: 0/2087 (0.0%)	SS: n=28; detection/mean Acta2 96.4%/105, Tagln 96.4%/71.6, Myh11 89.3%/15, Cnn1 39.3%/1.71, Entpd1 21.4%/0.44; pericyte pair 53.6%, contractile triple 89.3%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=2053; detection/mean Acta2 99.9%/131, Tagln 99.2%/90.7, Myh11 96.0%/17.1, Cnn1 29.3%/1.26, Entpd1 41.3%/0.889; pericyte pair 36.8%, contractile triple 95.7%, Schwann pair 0.2%, fibroblast pair 0.3% | D7: n=5 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/113, Tagln 60.0%/69.8, Myh11 100.0%/9.5, Cnn1 0.0%/0, Entpd1 20.0%/0.959; pericyte pair 60.0%, contractile triple 60.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/84.5, Tagln 100.0%/14.1, Myh11 0.0%/0, Cnn1 0.0%/0, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2327; median mitochondrial fraction 0.0627; predicted doublets 11/2087; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_20, cluster=1; source annotation_evidence/markers_pcs_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.794076+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
2	pcs_20	2	142	VSMC	VSMC	supported	Acta2: 98.6% detected, mean 121 versus rest 114; Tagln: 99.3% detected, mean 81 versus rest 73.5; Myh11: 93.0% detected, mean 16 versus rest 15.3; Cnn1: 36.6% detected, mean 1.49 versus rest 2.18; Entpd1: 36.6% detected, mean 0.747 versus rest 0.652	Other programs remain visible: same-cell pericyte pair and contractile triple 21.8%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	ba023fc64798efbc4d8875923bb675a84e2208cc86d3645b79efcf27786d1539	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 37/142 (26.1%); all four pericyte markers: 3/142 (2.1%); Acta2/Tagln/Myh11: 132/142 (93.0%); Cnn1/Entpd1: 25/142 (17.6%); Plp1/Cnp: 0/142 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/142 (0.0%); Pecam1/Cdh5: 0/142 (0.0%); Ptprc plus a listed subtype marker: 0/142 (0.0%)	SS: n=27; detection/mean Acta2 100.0%/112, Tagln 100.0%/70.2, Myh11 92.6%/16.6, Cnn1 29.6%/1.51, Entpd1 25.9%/0.914; pericyte pair 18.5%, contractile triple 92.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=77; detection/mean Acta2 100.0%/134, Tagln 100.0%/102, Myh11 100.0%/17.1, Cnn1 44.2%/1.57, Entpd1 54.5%/0.874; pericyte pair 26.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=11 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/114, Tagln 100.0%/42.8, Myh11 90.9%/12.3, Cnn1 36.4%/2.08, Entpd1 0.0%/0; pericyte pair 9.1%, contractile triple 90.9%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=27; detection/mean Acta2 92.6%/93.7, Tagln 96.3%/46.8, Myh11 74.1%/13.8, Cnn1 22.2%/1.03, Entpd1 11.1%/0.52; pericyte pair 40.7%, contractile triple 74.1%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2094; median mitochondrial fraction 0.0512; predicted doublets 0/142; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_20, cluster=2; source annotation_evidence/markers_pcs_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.813771+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
3	pcs_20	3	1316	pericyte	pericyte	supported	Kcnj8: 91.9% detected, mean 34.2 versus rest 3.47; Abcc9: 86.2% detected, mean 13 versus rest 2.97; Colec11: 93.1% detected, mean 24.7 versus rest 4.15; Vtn: 92.1% detected, mean 27.5 versus rest 3.99	Other programs remain visible: same-cell pericyte pair and contractile triple 8.5%; pericyte and fibroblast pairs 0.6%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	2e9d6f82c533a098b5f3873d9c81597703cbc0261865ce7b389e397a4d79b951	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1281/1316 (97.3%); all four pericyte markers: 980/1316 (74.5%); Acta2/Tagln/Myh11: 120/1316 (9.1%); Cnn1/Entpd1: 0/1316 (0.0%); Plp1/Cnp: 2/1316 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 9/1316 (0.7%); Pecam1/Cdh5: 0/1316 (0.0%); Ptprc plus a listed subtype marker: 0/1316 (0.0%)	SS: n=275; detection/mean Kcnj8 95.6%/31.5, Abcc9 90.9%/13.9, Colec11 96.0%/24, Vtn 95.6%/29.8; pericyte pair 99.3%, contractile triple 9.1%, Schwann pair 0.0%, fibroblast pair 0.7% | D3: n=50; detection/mean Kcnj8 80.0%/26.5, Abcc9 64.0%/13.1, Colec11 76.0%/21.2, Vtn 80.0%/21.7; pericyte pair 90.0%, contractile triple 8.0%, Schwann pair 0.0%, fibroblast pair 2.0% | D7: n=292; detection/mean Kcnj8 90.8%/35.1, Abcc9 84.9%/11.8, Colec11 95.2%/27.2, Vtn 92.1%/31.1; pericyte pair 97.3%, contractile triple 4.1%, Schwann pair 0.0%, fibroblast pair 1.4% | D42: n=699; detection/mean Kcnj8 91.8%/35.4, Abcc9 86.4%/13.1, Colec11 92.3%/24.2, Vtn 91.6%/25.5; pericyte pair 97.1%, contractile triple 11.3%, Schwann pair 0.3%, fibroblast pair 0.3%	median detected genes 1237; median mitochondrial fraction 0.0312; predicted doublets 5/1316; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_20, cluster=3; source annotation_evidence/markers_pcs_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.833368+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
4	pcs_20	4	432	Schwann	Schwann	supported	Plp1: 96.8% detected, mean 23 versus rest 0.0544; Cnp: 88.9% detected, mean 13.4 versus rest 0.106	Other programs remain visible: same-cell pericyte pair and contractile triple 1.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 13.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e6f997da9513413875ba350696d03eb9becd30a955298bb06266857351585789	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 14/432 (3.2%); all four pericyte markers: 3/432 (0.7%); Acta2/Tagln/Myh11: 64/432 (14.8%); Cnn1/Entpd1: 10/432 (2.3%); Plp1/Cnp: 378/432 (87.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/432 (0.0%); Pecam1/Cdh5: 0/432 (0.0%); Ptprc plus a listed subtype marker: 0/432 (0.0%)	SS: n=121; detection/mean Plp1 95.0%/22, Cnp 90.1%/18.5; pericyte pair 1.7%, contractile triple 9.1%, Schwann pair 86.8%, fibroblast pair 0.0% | D3: n=215; detection/mean Plp1 97.7%/20.1, Cnp 87.0%/8.13; pericyte pair 5.6%, contractile triple 24.7%, Schwann pair 86.5%, fibroblast pair 0.0% | D7: n=35; detection/mean Plp1 94.3%/31.6, Cnp 85.7%/15.4; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 82.9%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1888; median mitochondrial fraction 0.0288; predicted doublets 4/432; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_20, cluster=4; source annotation_evidence/markers_pcs_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.852676+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
5	pcs_20	5	2142	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 161 versus rest 107; Tagln: 99.9% detected, mean 99.8 versus rest 69.8; Myh11: 99.4% detected, mean 24.4 versus rest 14; Cnn1: 58.7% detected, mean 4.18 versus rest 1.89; Entpd1: 32.1% detected, mean 0.854 versus rest 0.625	Other programs remain visible: same-cell pericyte pair and contractile triple 3.0%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	91c04d3889d365a25e8ca8a2d9e1890ac45b7d9997ba1e99e0d1978da00b8862	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 65/2142 (3.0%); all four pericyte markers: 2/2142 (0.1%); Acta2/Tagln/Myh11: 2126/2142 (99.3%); Cnn1/Entpd1: 474/2142 (22.1%); Plp1/Cnp: 2/2142 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2142 (0.0%); Pecam1/Cdh5: 0/2142 (0.0%); Ptprc plus a listed subtype marker: 0/2142 (0.0%)	SS: n=2099; detection/mean Acta2 100.0%/160, Tagln 100.0%/99.5, Myh11 99.5%/24.2, Cnn1 58.6%/4.15, Entpd1 31.7%/0.846; pericyte pair 3.0%, contractile triple 99.4%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=32; detection/mean Acta2 100.0%/197, Tagln 100.0%/135, Myh11 93.8%/31.4, Cnn1 68.8%/6.39, Entpd1 50.0%/0.871; pericyte pair 3.1%, contractile triple 93.8%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=9 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/106, Tagln 88.9%/53.4, Myh11 100.0%/24.8, Cnn1 44.4%/3.19, Entpd1 55.6%/2.37; pericyte pair 0.0%, contractile triple 88.9%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=2 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/182, Tagln 100.0%/60.6, Myh11 100.0%/37.4, Cnn1 50.0%/5.24, Entpd1 100.0%/2.14; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1847; median mitochondrial fraction 0.0643; predicted doublets 7/2142; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_20, cluster=5; source annotation_evidence/markers_pcs_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.872370+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
6	pcs_20	6	989	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 276 versus rest 104; Tagln: 100.0% detected, mean 209 versus rest 65.2; Myh11: 99.9% detected, mean 34.7 versus rest 14.1; Cnn1: 98.6% detected, mean 9.05 versus rest 1.75; Entpd1: 65.5% detected, mean 1.27 versus rest 0.616	Other programs remain visible: same-cell pericyte pair and contractile triple 5.3%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	504d5285df7267560f9a16e17d1c60e56c34650a74edacf6450e7a1b9c5dd73c	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 53/989 (5.4%); all four pericyte markers: 6/989 (0.6%); Acta2/Tagln/Myh11: 988/989 (99.9%); Cnn1/Entpd1: 644/989 (65.1%); Plp1/Cnp: 2/989 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/989 (0.1%); Pecam1/Cdh5: 0/989 (0.0%); Ptprc plus a listed subtype marker: 0/989 (0.0%)	SS: n=159; detection/mean Acta2 100.0%/237, Tagln 100.0%/173, Myh11 99.4%/33.5, Cnn1 96.9%/10.8, Entpd1 42.1%/0.981; pericyte pair 2.5%, contractile triple 99.4%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=666; detection/mean Acta2 100.0%/290, Tagln 100.0%/232, Myh11 100.0%/34.9, Cnn1 99.2%/8.25, Entpd1 76.9%/1.36; pericyte pair 6.3%, contractile triple 100.0%, Schwann pair 0.3%, fibroblast pair 0.2% | D7: n=72; detection/mean Acta2 100.0%/244, Tagln 100.0%/147, Myh11 100.0%/35.7, Cnn1 97.2%/12, Entpd1 30.6%/0.897; pericyte pair 4.2%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=92; detection/mean Acta2 100.0%/264, Tagln 100.0%/152, Myh11 100.0%/33.7, Cnn1 97.8%/9.63, Entpd1 51.1%/1.39; pericyte pair 4.3%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2971; median mitochondrial fraction 0.0819; predicted doublets 0/989; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_20, cluster=6; source annotation_evidence/markers_pcs_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.893446+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
7	pcs_20	7	2994	VSMC	VSMC	supported	Acta2: 99.2% detected, mean 134 versus rest 110; Tagln: 98.3% detected, mean 67 versus rest 74.9; Myh11: 94.1% detected, mean 20.3 versus rest 14.2; Cnn1: 40.3% detected, mean 2.76 versus rest 2.05; Entpd1: 22.3% detected, mean 0.736 versus rest 0.636	Other programs remain visible: same-cell pericyte pair and contractile triple 10.1%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	44dedbd37bd98b0bdc34b41b388da66fc98e8df2f9921dc72b4063703493b7fc	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 379/2994 (12.7%); all four pericyte markers: 33/2994 (1.1%); Acta2/Tagln/Myh11: 2792/2994 (93.3%); Cnn1/Entpd1: 378/2994 (12.6%); Plp1/Cnp: 2/2994 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2994 (0.0%); Pecam1/Cdh5: 0/2994 (0.0%); Ptprc plus a listed subtype marker: 0/2994 (0.0%)	SS: n=46; detection/mean Acta2 100.0%/110, Tagln 95.7%/69.3, Myh11 82.6%/16.6, Cnn1 26.1%/1.31, Entpd1 8.7%/0.253; pericyte pair 15.2%, contractile triple 82.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=19 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 94.7%/128, Tagln 94.7%/86.4, Myh11 63.2%/20.8, Cnn1 21.1%/2.32, Entpd1 10.5%/0.461; pericyte pair 26.3%, contractile triple 63.2%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=1370; detection/mean Acta2 98.4%/122, Tagln 97.3%/58.6, Myh11 93.7%/19, Cnn1 38.8%/2.66, Entpd1 20.8%/0.713; pericyte pair 12.4%, contractile triple 92.5%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1559; detection/mean Acta2 99.9%/146, Tagln 99.2%/74, Myh11 95.1%/21.5, Cnn1 42.4%/2.9, Entpd1 24.2%/0.774; pericyte pair 12.6%, contractile triple 94.6%, Schwann pair 0.1%, fibroblast pair 0.0%	median detected genes 1472; median mitochondrial fraction 0.0627; predicted doublets 6/2994; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_20, cluster=7; source annotation_evidence/markers_pcs_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.924940+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
8	pcs_20	8	3015	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 146 versus rest 107; Tagln: 100.0% detected, mean 106 versus rest 66.5; Myh11: 99.4% detected, mean 18.8 versus rest 14.5; Cnn1: 49.5% detected, mean 1.95 versus rest 2.22; Entpd1: 53.8% detected, mean 1.13 versus rest 0.551	Other programs remain visible: same-cell pericyte pair and contractile triple 10.1%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	53b944becd3c864de91ff7ac727bf43cb1ba254fecc4e2a31667d285f8982a04	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 307/3015 (10.2%); all four pericyte markers: 18/3015 (0.6%); Acta2/Tagln/Myh11: 2996/3015 (99.4%); Cnn1/Entpd1: 972/3015 (32.2%); Plp1/Cnp: 2/3015 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/3015 (0.0%); Pecam1/Cdh5: 0/3015 (0.0%); Ptprc plus a listed subtype marker: 0/3015 (0.0%)	SS: n=28; detection/mean Acta2 100.0%/150, Tagln 100.0%/89.2, Myh11 100.0%/23.5, Cnn1 71.4%/3.66, Entpd1 35.7%/0.696; pericyte pair 3.6%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=2986; detection/mean Acta2 100.0%/146, Tagln 100.0%/106, Myh11 99.4%/18.7, Cnn1 49.3%/1.93, Entpd1 54.0%/1.13; pericyte pair 10.2%, contractile triple 99.4%, Schwann pair 0.1%, fibroblast pair 0.0% | D7: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/129, Tagln 100.0%/59.2, Myh11 100.0%/31.7, Cnn1 100.0%/2.11, Entpd1 100.0%/2.11; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 2496; median mitochondrial fraction 0.0658; predicted doublets 0/3015; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_20, cluster=8; source annotation_evidence/markers_pcs_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.945184+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
9	pcs_20	9	1616	pericyte	pericyte	supported	Kcnj8: 92.8% detected, mean 23.9 versus rest 3.95; Abcc9: 96.7% detected, mean 21.3 versus rest 1.91; Colec11: 92.6% detected, mean 20.5 versus rest 4.2; Vtn: 92.6% detected, mean 17.7 versus rest 4.56	Other programs remain visible: same-cell pericyte pair and contractile triple 22.1%; pericyte and fibroblast pairs 1.1%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	19af1491f1509654714dca9e4019e36b547961446276ffe13a17ed67a731edd1	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1585/1616 (98.1%); all four pericyte markers: 1338/1616 (82.8%); Acta2/Tagln/Myh11: 367/1616 (22.7%); Cnn1/Entpd1: 0/1616 (0.0%); Plp1/Cnp: 2/1616 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 17/1616 (1.1%); Pecam1/Cdh5: 0/1616 (0.0%); Ptprc plus a listed subtype marker: 0/1616 (0.0%)	SS: n=18 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 94.4%/25.9, Abcc9 88.9%/15.2, Colec11 100.0%/20.2, Vtn 100.0%/27.7; pericyte pair 100.0%, contractile triple 22.2%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1596; detection/mean Kcnj8 92.8%/23.9, Abcc9 96.7%/21.3, Colec11 92.5%/20.5, Vtn 92.5%/17.6; pericyte pair 98.1%, contractile triple 22.7%, Schwann pair 0.1%, fibroblast pair 1.1% | D7: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 0.0%/0, Abcc9 100.0%/10.8, Colec11 0.0%/0, Vtn 100.0%/10.8; pericyte pair 100.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/19.7, Abcc9 100.0%/27.6, Colec11 100.0%/35.5, Vtn 100.0%/11.8; pericyte pair 100.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1746.5; median mitochondrial fraction 0.0442; predicted doublets 0/1616; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_20, cluster=9; source annotation_evidence/markers_pcs_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.965343+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
10	pcs_20	10	1388	pericyte	pericyte	supported	Kcnj8: 73.8% detected, mean 7.34 versus rest 5.7; Abcc9: 74.4% detected, mean 4.48 versus rest 3.68; Colec11: 83.5% detected, mean 16.3 versus rest 4.81; Vtn: 86.5% detected, mean 13.8 versus rest 5.1	Other programs remain visible: same-cell pericyte pair and contractile triple 48.3%; pericyte and fibroblast pairs 9.4%; Schwann pair and contractile triple 0.4%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	031e2f2bc5a32a392c9b0b31f096991950a52a42e87eb45286489d0fd8fca315	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1261/1388 (90.9%); all four pericyte markers: 740/1388 (53.3%); Acta2/Tagln/Myh11: 741/1388 (53.4%); Cnn1/Entpd1: 29/1388 (2.1%); Plp1/Cnp: 7/1388 (0.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 158/1388 (11.4%); Pecam1/Cdh5: 0/1388 (0.0%); Ptprc plus a listed subtype marker: 0/1388 (0.0%)	SS: n=82; detection/mean Kcnj8 58.5%/5.67, Abcc9 45.1%/1.85, Colec11 80.5%/20.1, Vtn 75.6%/23.8; pericyte pair 78.0%, contractile triple 67.1%, Schwann pair 0.0%, fibroblast pair 14.6% | D3: n=590; detection/mean Kcnj8 73.4%/4.39, Abcc9 85.9%/4.81, Colec11 72.2%/5.55, Vtn 85.6%/6.21; pericyte pair 88.8%, contractile triple 71.0%, Schwann pair 0.8%, fibroblast pair 13.1% | D7: n=507; detection/mean Kcnj8 77.7%/10.3, Abcc9 73.8%/4.94, Colec11 92.5%/22.6, Vtn 86.6%/13.9; pericyte pair 93.7%, contractile triple 34.3%, Schwann pair 0.4%, fibroblast pair 11.2% | D42: n=209; detection/mean Kcnj8 71.8%/9.08, Abcc9 55.0%/3.44, Colec11 94.7%/29.6, Vtn 93.3%/30.9; pericyte pair 94.7%, contractile triple 44.5%, Schwann pair 0.0%, fibroblast pair 5.7%	median detected genes 2423; median mitochondrial fraction 0.0327; predicted doublets 3/1388; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_20, cluster=10; source annotation_evidence/markers_pcs_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:58.984870+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
11	pcs_20	11	253	fibroblast	fibroblast	supported	Pdgfra: 58.5% detected, mean 0.857 versus rest 0.00242; Lum: 96.0% detected, mean 25.6 versus rest 0.0572; Dcn: 99.6% detected, mean 70.5 versus rest 0.575; Cd34: 82.2% detected, mean 3.41 versus rest 0.0252	Other programs remain visible: same-cell pericyte pair and contractile triple 2.4%; pericyte and fibroblast pairs 7.5%; Schwann pair and contractile triple 1.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	67bba9cd4d8503380422318f4b2d504cf5d46795d72bca7a6e63d5f9e35a516b	SCP002-A001	accepted_versioned_annotation_decision	F	at least two of Kcnj8/Abcc9/Colec11/Vtn: 19/253 (7.5%); all four pericyte markers: 4/253 (1.6%); Acta2/Tagln/Myh11: 47/253 (18.6%); Cnn1/Entpd1: 3/253 (1.2%); Plp1/Cnp: 3/253 (1.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 252/253 (99.6%); Pecam1/Cdh5: 0/253 (0.0%); Ptprc plus a listed subtype marker: 0/253 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=82; detection/mean Pdgfra 76.8%/0.923, Lum 92.7%/6.54, Dcn 98.8%/21, Cd34 74.4%/1.32; pericyte pair 14.6%, contractile triple 43.9%, Schwann pair 1.2%, fibroblast pair 98.8% | D7: n=164; detection/mean Pdgfra 49.4%/0.777, Lum 97.6%/33.4, Dcn 100.0%/89.5, Cd34 86.0%/4.33; pericyte pair 4.3%, contractile triple 6.7%, Schwann pair 1.2%, fibroblast pair 100.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Pdgfra 57.1%/1.96, Lum 100.0%/66.5, Dcn 100.0%/206, Cd34 85.7%/6.26; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 100.0%	median detected genes 3432; median mitochondrial fraction 0.0239; predicted doublets 0/253; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_20, cluster=11; source annotation_evidence/markers_pcs_20/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.000553+00:00	supported	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	supported_broad_identity_retained
0	pcs_50	0	2725	VSMC	VSMC	supported	Acta2: 99.7% detected, mean 151 versus rest 107; Tagln: 99.5% detected, mean 91.9 versus rest 70; Myh11: 97.6% detected, mean 22.2 versus rest 14; Cnn1: 48.3% detected, mean 3.31 versus rest 1.96; Entpd1: 28.7% detected, mean 0.78 versus rest 0.629	Other programs remain visible: same-cell pericyte pair and contractile triple 6.9%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	00b8cd821d60572f14ea3b1d0caa840b5448f4584c8b36fb2cd4744a08f8517f	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 219/2725 (8.0%); all four pericyte markers: 9/2725 (0.3%); Acta2/Tagln/Myh11: 2648/2725 (97.2%); Cnn1/Entpd1: 470/2725 (17.2%); Plp1/Cnp: 3/2725 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2725 (0.0%); Pecam1/Cdh5: 0/2725 (0.0%); Ptprc plus a listed subtype marker: 0/2725 (0.0%)	SS: n=2670; detection/mean Acta2 99.7%/150, Tagln 99.5%/91.6, Myh11 97.8%/22, Cnn1 48.4%/3.28, Entpd1 28.7%/0.778; pericyte pair 8.1%, contractile triple 97.3%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=38; detection/mean Acta2 100.0%/182, Tagln 100.0%/122, Myh11 92.1%/29, Cnn1 50.0%/4.3, Entpd1 26.3%/0.581; pericyte pair 5.3%, contractile triple 92.1%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=10 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/83.4, Tagln 90.0%/48.3, Myh11 90.0%/21.9, Cnn1 20.0%/1.97, Entpd1 30.0%/1.94; pericyte pair 20.0%, contractile triple 80.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/163, Tagln 100.0%/77.7, Myh11 85.7%/30.1, Cnn1 42.9%/9.06, Entpd1 42.9%/0.929; pericyte pair 0.0%, contractile triple 85.7%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1793; median mitochondrial fraction 0.0597; predicted doublets 7/2725; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_50, cluster=0; source annotation_evidence/markers_pcs_50/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.021290+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
1	pcs_50	1	1022	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 275 versus rest 104; Tagln: 99.9% detected, mean 208 versus rest 65; Myh11: 99.6% detected, mean 34.6 versus rest 14; Cnn1: 98.7% detected, mean 9.14 versus rest 1.73; Entpd1: 64.8% detected, mean 1.29 versus rest 0.613	Other programs remain visible: same-cell pericyte pair and contractile triple 5.3%; pericyte and fibroblast pairs 0.2%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	4ade8641cfe19c0f2ecdbb1aa451bc0c348e3b019beed8ab45c2a104dc639a36	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 55/1022 (5.4%); all four pericyte markers: 5/1022 (0.5%); Acta2/Tagln/Myh11: 1018/1022 (99.6%); Cnn1/Entpd1: 659/1022 (64.5%); Plp1/Cnp: 2/1022 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 8/1022 (0.8%); Pecam1/Cdh5: 0/1022 (0.0%); Ptprc plus a listed subtype marker: 0/1022 (0.0%)	SS: n=203; detection/mean Acta2 100.0%/237, Tagln 100.0%/174, Myh11 98.5%/35.4, Cnn1 98.0%/11.2, Entpd1 43.8%/1.13; pericyte pair 3.9%, contractile triple 98.5%, Schwann pair 0.0%, fibroblast pair 2.5% | D3: n=652; detection/mean Acta2 100.0%/293, Tagln 100.0%/234, Myh11 100.0%/34.3, Cnn1 99.4%/8.2, Entpd1 77.5%/1.4; pericyte pair 6.1%, contractile triple 100.0%, Schwann pair 0.3%, fibroblast pair 0.3% | D7: n=78; detection/mean Acta2 98.7%/239, Tagln 98.7%/143, Myh11 98.7%/35.2, Cnn1 96.2%/11.6, Entpd1 28.2%/0.825; pericyte pair 3.8%, contractile triple 98.7%, Schwann pair 0.0%, fibroblast pair 1.3% | D42: n=89; detection/mean Acta2 100.0%/266, Tagln 100.0%/153, Myh11 100.0%/33.8, Cnn1 97.8%/9.2, Entpd1 51.7%/1.3; pericyte pair 4.5%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2879; median mitochondrial fraction 0.0833; predicted doublets 0/1022; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_50, cluster=1; source annotation_evidence/markers_pcs_50/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.041477+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
2	pcs_50	2	1718	VSMC	VSMC	supported	Acta2: 99.8% detected, mean 116 versus rest 114; Tagln: 98.5% detected, mean 78.8 versus rest 72.9; Myh11: 94.1% detected, mean 15.4 versus rest 15.2; Cnn1: 20.7% detected, mean 0.757 versus rest 2.33; Entpd1: 36.2% detected, mean 0.796 versus rest 0.637	Other programs remain visible: same-cell pericyte pair and contractile triple 35.6%; pericyte and fibroblast pairs 0.1%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	6f598aff60c948e25ba919b41b728d7332d62422c49176dc9803cd4248c861a6	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 687/1718 (40.0%); all four pericyte markers: 158/1718 (9.2%); Acta2/Tagln/Myh11: 1609/1718 (93.7%); Cnn1/Entpd1: 216/1718 (12.6%); Plp1/Cnp: 3/1718 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 3/1718 (0.2%); Pecam1/Cdh5: 0/1718 (0.0%); Ptprc plus a listed subtype marker: 0/1718 (0.0%)	SS: n=53; detection/mean Acta2 98.1%/102, Tagln 92.5%/57.4, Myh11 90.6%/14.1, Cnn1 20.8%/1.04, Entpd1 17.0%/0.41; pericyte pair 24.5%, contractile triple 86.8%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1650; detection/mean Acta2 99.9%/117, Tagln 99.0%/79.8, Myh11 94.2%/15.5, Cnn1 20.7%/0.746, Entpd1 37.0%/0.812; pericyte pair 40.4%, contractile triple 94.1%, Schwann pair 0.2%, fibroblast pair 0.2% | D7: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/107, Tagln 71.4%/64.3, Myh11 100.0%/11.9, Cnn1 28.6%/1.03, Entpd1 14.3%/0.685; pericyte pair 42.9%, contractile triple 71.4%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=8 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/83, Tagln 75.0%/29.2, Myh11 75.0%/11.1, Cnn1 12.5%/0.938, Entpd1 12.5%/0.234; pericyte pair 50.0%, contractile triple 62.5%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2192.5; median mitochondrial fraction 0.0555; predicted doublets 0/1718; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_50, cluster=2; source annotation_evidence/markers_pcs_50/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.061488+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
3	pcs_50	3	432	Schwann	Schwann	supported	Plp1: 97.0% detected, mean 23.1 versus rest 0.0535; Cnp: 89.1% detected, mean 13.4 versus rest 0.106	Other programs remain visible: same-cell pericyte pair and contractile triple 1.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 13.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	68fa5af2efec958cf56d999c144df71598c843810005b5ddc95ba9d22ff2ef2a	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 14/432 (3.2%); all four pericyte markers: 3/432 (0.7%); Acta2/Tagln/Myh11: 64/432 (14.8%); Cnn1/Entpd1: 10/432 (2.3%); Plp1/Cnp: 379/432 (87.7%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/432 (0.0%); Pecam1/Cdh5: 0/432 (0.0%); Ptprc plus a listed subtype marker: 0/432 (0.0%)	SS: n=121; detection/mean Plp1 95.0%/22, Cnp 90.1%/18.5; pericyte pair 1.7%, contractile triple 9.1%, Schwann pair 86.8%, fibroblast pair 0.0% | D3: n=216; detection/mean Plp1 97.7%/20.1, Cnp 87.0%/8.11; pericyte pair 5.6%, contractile triple 24.5%, Schwann pair 86.6%, fibroblast pair 0.0% | D7: n=34; detection/mean Plp1 97.1%/32.6, Cnp 88.2%/15.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 85.3%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1891.5; median mitochondrial fraction 0.0289; predicted doublets 4/432; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_50, cluster=3; source annotation_evidence/markers_pcs_50/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.080813+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
4	pcs_50	4	2999	VSMC	VSMC	supported	Acta2: 98.9% detected, mean 133 versus rest 110; Tagln: 97.9% detected, mean 66.4 versus rest 75; Myh11: 93.3% detected, mean 20.1 versus rest 14.2; Cnn1: 40.4% detected, mean 2.76 versus rest 2.05; Entpd1: 22.4% detected, mean 0.746 versus rest 0.634	Other programs remain visible: same-cell pericyte pair and contractile triple 9.7%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	9721c534a74b2838acf9a17bb36a329fff775aef6e68b1a3180866e45509435c	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 381/2999 (12.7%); all four pericyte markers: 37/2999 (1.2%); Acta2/Tagln/Myh11: 2776/2999 (92.6%); Cnn1/Entpd1: 382/2999 (12.7%); Plp1/Cnp: 2/2999 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2999 (0.0%); Pecam1/Cdh5: 0/2999 (0.0%); Ptprc plus a listed subtype marker: 0/2999 (0.0%)	SS: n=27; detection/mean Acta2 96.3%/95, Tagln 81.5%/57.7, Myh11 77.8%/14.8, Cnn1 22.2%/1.41, Entpd1 11.1%/0.607; pericyte pair 18.5%, contractile triple 74.1%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=12 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/139, Tagln 100.0%/100, Myh11 50.0%/20.7, Cnn1 25.0%/3.51, Entpd1 16.7%/0.73; pericyte pair 8.3%, contractile triple 50.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=1352; detection/mean Acta2 98.4%/123, Tagln 97.5%/58.8, Myh11 93.2%/19, Cnn1 39.3%/2.68, Entpd1 21.1%/0.723; pericyte pair 10.7%, contractile triple 92.5%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1608; detection/mean Acta2 99.3%/143, Tagln 98.4%/72.6, Myh11 93.9%/21.1, Cnn1 41.7%/2.85, Entpd1 23.8%/0.768; pericyte pair 14.4%, contractile triple 93.2%, Schwann pair 0.1%, fibroblast pair 0.0%	median detected genes 1468; median mitochondrial fraction 0.0624; predicted doublets 8/2999; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_50, cluster=4; source annotation_evidence/markers_pcs_50/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.101992+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
5	pcs_50	5	1470	pericyte	pericyte	supported	Kcnj8: 88.6% detected, mean 30.9 versus rest 3.48; Abcc9: 82.1% detected, mean 12 versus rest 2.97; Colec11: 92.6% detected, mean 23.7 versus rest 4.05; Vtn: 91.8% detected, mean 26.2 versus rest 3.88	Other programs remain visible: same-cell pericyte pair and contractile triple 12.8%; pericyte and fibroblast pairs 0.4%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	14d9b69b534bd82ad8d575fd5cd7ae98895fbf94135840ff1dbf3dd868074382	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1421/1470 (96.7%); all four pericyte markers: 1023/1470 (69.6%); Acta2/Tagln/Myh11: 204/1470 (13.9%); Cnn1/Entpd1: 0/1470 (0.0%); Plp1/Cnp: 2/1470 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 7/1470 (0.5%); Pecam1/Cdh5: 0/1470 (0.0%); Ptprc plus a listed subtype marker: 0/1470 (0.0%)	SS: n=383; detection/mean Kcnj8 89.6%/24.4, Abcc9 82.5%/11.6, Colec11 93.7%/21, Vtn 95.3%/25.5; pericyte pair 97.9%, contractile triple 19.1%, Schwann pair 0.0%, fibroblast pair 0.3% | D3: n=56; detection/mean Kcnj8 66.1%/23.6, Abcc9 57.1%/13.5, Colec11 73.2%/18.6, Vtn 64.3%/17.4; pericyte pair 82.1%, contractile triple 14.3%, Schwann pair 0.0%, fibroblast pair 1.8% | D7: n=308; detection/mean Kcnj8 87.0%/31.4, Abcc9 78.6%/10.5, Colec11 94.8%/25.6, Vtn 91.9%/28.3; pericyte pair 97.1%, contractile triple 13.3%, Schwann pair 0.0%, fibroblast pair 0.6% | D42: n=723; detection/mean Kcnj8 90.5%/34.7, Abcc9 85.3%/12.7, Colec11 92.5%/24.8, Vtn 92.0%/26.4; pericyte pair 97.0%, contractile triple 11.3%, Schwann pair 0.3%, fibroblast pair 0.4%	median detected genes 1238.5; median mitochondrial fraction 0.0311; predicted doublets 3/1470; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_50, cluster=5; source annotation_evidence/markers_pcs_50/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.121906+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
6	pcs_50	6	1347	pericyte	pericyte	supported	Kcnj8: 75.7% detected, mean 7.82 versus rest 5.67; Abcc9: 76.8% detected, mean 4.85 versus rest 3.65; Colec11: 84.0% detected, mean 15.9 versus rest 4.87; Vtn: 87.5% detected, mean 13.2 versus rest 5.17	Other programs remain visible: same-cell pericyte pair and contractile triple 48.9%; pericyte and fibroblast pairs 9.9%; Schwann pair and contractile triple 0.4%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e8a12b9c15ee6cb9adc75b0719a88cb71b3fd219419d09f44e76f2a59a352843	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1239/1347 (92.0%); all four pericyte markers: 750/1347 (55.7%); Acta2/Tagln/Myh11: 719/1347 (53.4%); Cnn1/Entpd1: 25/1347 (1.9%); Plp1/Cnp: 6/1347 (0.4%); at least two of Pdgfra/Lum/Dcn/Cd34: 156/1347 (11.6%); Pecam1/Cdh5: 0/1347 (0.0%); Ptprc plus a listed subtype marker: 0/1347 (0.0%)	SS: n=63; detection/mean Kcnj8 61.9%/5.85, Abcc9 47.6%/2.1, Colec11 88.9%/21.7, Vtn 85.7%/25.4; pericyte pair 87.3%, contractile triple 71.4%, Schwann pair 0.0%, fibroblast pair 12.7% | D3: n=608; detection/mean Kcnj8 74.7%/5.04, Abcc9 86.8%/5.31, Colec11 73.4%/5.94, Vtn 86.5%/6.41; pericyte pair 89.6%, contractile triple 69.6%, Schwann pair 0.7%, fibroblast pair 12.8% | D7: n=519; detection/mean Kcnj8 79.6%/11.3, Abcc9 74.8%/5.16, Colec11 92.7%/22.7, Vtn 86.7%/14.4; pericyte pair 94.2%, contractile triple 32.8%, Schwann pair 0.4%, fibroblast pair 11.4% | D42: n=157; detection/mean Kcnj8 72.6%/7.94, Abcc9 56.1%/3.09, Colec11 94.9%/29.5, Vtn 94.3%/30.7; pericyte pair 95.5%, contractile triple 51.6%, Schwann pair 0.0%, fibroblast pair 7.0%	median detected genes 2513; median mitochondrial fraction 0.0327; predicted doublets 3/1347; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_50, cluster=6; source annotation_evidence/markers_pcs_50/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.142032+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
7	pcs_50	7	3548	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 150 versus rest 104; Tagln: 99.9% detected, mean 109 versus rest 64.3; Myh11: 99.3% detected, mean 19.4 versus rest 14.2; Cnn1: 51.0% detected, mean 2.14 versus rest 2.18; Entpd1: 53.9% detected, mean 1.11 versus rest 0.533	Other programs remain visible: same-cell pericyte pair and contractile triple 12.4%; pericyte and fibroblast pairs 0.1%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	230e0e65418d33b4f5eb9cc5a4e9c1ce9d3bc4be20a9bc410191944c0ba16ceb	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 445/3548 (12.5%); all four pericyte markers: 105/3548 (3.0%); Acta2/Tagln/Myh11: 3521/3548 (99.2%); Cnn1/Entpd1: 1189/3548 (33.5%); Plp1/Cnp: 3/3548 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 4/3548 (0.1%); Pecam1/Cdh5: 0/3548 (0.0%); Ptprc plus a listed subtype marker: 0/3548 (0.0%)	SS: n=43; detection/mean Acta2 100.0%/135, Tagln 100.0%/85.4, Myh11 100.0%/23.1, Cnn1 67.4%/3.94, Entpd1 30.2%/0.539; pericyte pair 25.6%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=3505; detection/mean Acta2 100.0%/150, Tagln 99.9%/109, Myh11 99.3%/19.3, Cnn1 50.8%/2.12, Entpd1 54.2%/1.12; pericyte pair 12.4%, contractile triple 99.2%, Schwann pair 0.1%, fibroblast pair 0.1% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2524.5; median mitochondrial fraction 0.0675; predicted doublets 9/3548; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_50, cluster=7; source annotation_evidence/markers_pcs_50/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.153104+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
8	pcs_50	8	1594	pericyte	pericyte	supported	Kcnj8: 93.1% detected, mean 24.2 versus rest 3.95; Abcc9: 96.7% detected, mean 21.3 versus rest 1.93; Colec11: 93.1% detected, mean 20.8 versus rest 4.19; Vtn: 92.7% detected, mean 18 versus rest 4.55	Other programs remain visible: same-cell pericyte pair and contractile triple 22.1%; pericyte and fibroblast pairs 0.9%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	de86b07fdc04e02cda1e9e51634cac1f20ecd3bad16bd6df97914e2c6678dda9	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1569/1594 (98.4%); all four pericyte markers: 1324/1594 (83.1%); Acta2/Tagln/Myh11: 359/1594 (22.5%); Cnn1/Entpd1: 3/1594 (0.2%); Plp1/Cnp: 2/1594 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 15/1594 (0.9%); Pecam1/Cdh5: 0/1594 (0.0%); Ptprc plus a listed subtype marker: 0/1594 (0.0%)	SS: n=31; detection/mean Kcnj8 93.5%/28.6, Abcc9 93.5%/13, Colec11 93.5%/20.9, Vtn 93.5%/25.7; pericyte pair 100.0%, contractile triple 9.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1560; detection/mean Kcnj8 93.1%/24.1, Abcc9 96.7%/21.5, Colec11 93.2%/20.8, Vtn 92.8%/17.8; pericyte pair 98.4%, contractile triple 22.8%, Schwann pair 0.1%, fibroblast pair 1.0% | D7: n=3 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 66.7%/15.5, Abcc9 100.0%/28, Colec11 33.3%/15.9, Vtn 66.7%/16.4; pericyte pair 100.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 1743.5; median mitochondrial fraction 0.0442; predicted doublets 2/1594; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_50, cluster=8; source annotation_evidence/markers_pcs_50/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.168059+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
9	pcs_50	9	252	fibroblast	fibroblast	supported	Pdgfra: 58.3% detected, mean 0.855 versus rest 0.0025; Lum: 96.0% detected, mean 25.7 versus rest 0.0579; Dcn: 99.6% detected, mean 70.6 versus rest 0.578; Cd34: 82.1% detected, mean 3.42 versus rest 0.0252	Other programs remain visible: same-cell pericyte pair and contractile triple 2.0%; pericyte and fibroblast pairs 7.1%; Schwann pair and contractile triple 1.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	6faaaabc9678af783ebe922c2bfb80c8417fa921f16b44f1c0a9882253eaf323	SCP002-A001	accepted_versioned_annotation_decision	F	at least two of Kcnj8/Abcc9/Colec11/Vtn: 18/252 (7.1%); all four pericyte markers: 4/252 (1.6%); Acta2/Tagln/Myh11: 46/252 (18.3%); Cnn1/Entpd1: 3/252 (1.2%); Plp1/Cnp: 3/252 (1.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 251/252 (99.6%); Pecam1/Cdh5: 0/252 (0.0%); Ptprc plus a listed subtype marker: 0/252 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=82; detection/mean Pdgfra 76.8%/0.923, Lum 92.7%/6.54, Dcn 98.8%/21, Cd34 74.4%/1.32; pericyte pair 14.6%, contractile triple 43.9%, Schwann pair 1.2%, fibroblast pair 98.8% | D7: n=163; detection/mean Pdgfra 49.1%/0.773, Lum 97.5%/33.5, Dcn 100.0%/89.8, Cd34 85.9%/4.35; pericyte pair 3.7%, contractile triple 6.1%, Schwann pair 1.2%, fibroblast pair 100.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Pdgfra 57.1%/1.96, Lum 100.0%/66.5, Dcn 100.0%/206, Cd34 85.7%/6.26; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 100.0%	median detected genes 3441; median mitochondrial fraction 0.0239; predicted doublets 0/252; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=pcs_50, cluster=9; source annotation_evidence/markers_pcs_50/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.183401+00:00	supported	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	supported_broad_identity_retained
0	predicted_doublets_removed	0	2901	VSMC	VSMC	supported	Acta2: 99.8% detected, mean 156 versus rest 105; Tagln: 99.6% detected, mean 96.8 versus rest 68.8; Myh11: 98.0% detected, mean 23 versus rest 13.7; Cnn1: 51.2% detected, mean 3.75 versus rest 1.85; Entpd1: 29.7% detected, mean 0.808 versus rest 0.622	Other programs remain visible: same-cell pericyte pair and contractile triple 6.9%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	fe8e34711478646207be77945a2ea19751efe1460f65d4816615a6afa625868d	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 226/2901 (7.8%); all four pericyte markers: 9/2901 (0.3%); Acta2/Tagln/Myh11: 2830/2901 (97.6%); Cnn1/Entpd1: 550/2901 (19.0%); Plp1/Cnp: 3/2901 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2901 (0.0%); Pecam1/Cdh5: 0/2901 (0.0%); Ptprc plus a listed subtype marker: 0/2901 (0.0%)	SS: n=2841; detection/mean Acta2 99.8%/156, Tagln 99.6%/96.6, Myh11 98.1%/22.9, Cnn1 51.3%/3.74, Entpd1 29.6%/0.799; pericyte pair 7.8%, contractile triple 97.7%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=45; detection/mean Acta2 100.0%/171, Tagln 100.0%/114, Myh11 88.9%/25.9, Cnn1 42.2%/3.65, Entpd1 31.1%/1.23; pericyte pair 6.7%, contractile triple 88.9%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=12 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/125, Tagln 100.0%/99.8, Myh11 100.0%/39.8, Cnn1 58.3%/7.14, Entpd1 33.3%/1.34; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=3 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/176, Tagln 100.0%/53.4, Myh11 100.0%/30.1, Cnn1 33.3%/3.49, Entpd1 66.7%/1.43; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1815; median mitochondrial fraction 0.0607; predicted doublets 0/2901; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=predicted_doublets_removed, cluster=0; source annotation_evidence/markers_predicted_doublets_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.205590+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
1	predicted_doublets_removed	1	1369	pericyte	pericyte	supported	Kcnj8: 88.8% detected, mean 31.5 versus rest 3.59; Abcc9: 82.2% detected, mean 12.4 versus rest 2.98; Colec11: 91.2% detected, mean 23 versus rest 4.23; Vtn: 91.2% detected, mean 25.7 versus rest 4.07	Other programs remain visible: same-cell pericyte pair and contractile triple 12.3%; pericyte and fibroblast pairs 0.3%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	89c309005e9650977d74f54ff563700e1e5d96d4201a29d2c6ac424488211fa0	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1318/1369 (96.3%); all four pericyte markers: 944/1369 (69.0%); Acta2/Tagln/Myh11: 182/1369 (13.3%); Cnn1/Entpd1: 0/1369 (0.0%); Plp1/Cnp: 2/1369 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 5/1369 (0.4%); Pecam1/Cdh5: 0/1369 (0.0%); Ptprc plus a listed subtype marker: 0/1369 (0.0%)	SS: n=388; detection/mean Kcnj8 91.0%/25.5, Abcc9 83.2%/11.8, Colec11 94.3%/21.1, Vtn 94.8%/25.5; pericyte pair 98.5%, contractile triple 17.0%, Schwann pair 0.0%, fibroblast pair 0.3% | D3: n=59; detection/mean Kcnj8 78.0%/25.6, Abcc9 59.3%/13.9, Colec11 74.6%/19.2, Vtn 74.6%/19.4; pericyte pair 86.4%, contractile triple 6.8%, Schwann pair 0.0%, fibroblast pair 1.7% | D7: n=222; detection/mean Kcnj8 86.5%/33.9, Abcc9 80.2%/12, Colec11 92.8%/26.2, Vtn 90.5%/30.4; pericyte pair 95.9%, contractile triple 9.0%, Schwann pair 0.0%, fibroblast pair 0.9% | D42: n=700; detection/mean Kcnj8 89.1%/34.6, Abcc9 84.1%/12.8, Colec11 90.4%/23.3, Vtn 90.7%/24.8; pericyte pair 96.0%, contractile triple 13.1%, Schwann pair 0.3%, fibroblast pair 0.1%	median detected genes 1225; median mitochondrial fraction 0.031; predicted doublets 0/1369; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=predicted_doublets_removed, cluster=1; source annotation_evidence/markers_predicted_doublets_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.227953+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
2	predicted_doublets_removed	2	1011	pericyte	pericyte	supported	Kcnj8: 74.8% detected, mean 10.9 versus rest 5.51; Abcc9: 71.4% detected, mean 4.67 versus rest 3.68; Colec11: 92.0% detected, mean 23 versus rest 4.65; Vtn: 89.4% detected, mean 19.8 versus rest 4.92	Other programs remain visible: same-cell pericyte pair and contractile triple 40.0%; pericyte and fibroblast pairs 8.5%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	d1726cc515a729bd4a306be1a8a532cfee489c9378d1c21208d648a3d791c841	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 951/1011 (94.1%); all four pericyte markers: 557/1011 (55.1%); Acta2/Tagln/Myh11: 443/1011 (43.8%); Cnn1/Entpd1: 20/1011 (2.0%); Plp1/Cnp: 2/1011 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 111/1011 (11.0%); Pecam1/Cdh5: 0/1011 (0.0%); Ptprc plus a listed subtype marker: 0/1011 (0.0%)	SS: n=74; detection/mean Kcnj8 59.5%/5.74, Abcc9 45.9%/1.91, Colec11 82.4%/21, Vtn 73.0%/25; pericyte pair 79.7%, contractile triple 68.9%, Schwann pair 0.0%, fibroblast pair 16.2% | D3: n=151; detection/mean Kcnj8 60.3%/2.27, Abcc9 80.1%/3, Colec11 79.5%/8.59, Vtn 92.1%/12.6; pericyte pair 91.4%, contractile triple 88.1%, Schwann pair 0.7%, fibroblast pair 19.9% | D7: n=566; detection/mean Kcnj8 80.7%/14, Abcc9 77.4%/5.83, Colec11 94.9%/24.1, Vtn 89.0%/16.5; pericyte pair 95.8%, contractile triple 28.8%, Schwann pair 0.2%, fibroblast pair 9.9% | D42: n=220; detection/mean Kcnj8 74.5%/10.7, Abcc9 58.6%/3.76, Colec11 96.4%/30.6, Vtn 94.1%/31.5; pericyte pair 96.4%, contractile triple 43.6%, Schwann pair 0.0%, fibroblast pair 5.9%	median detected genes 2008; median mitochondrial fraction 0.0309; predicted doublets 0/1011; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=predicted_doublets_removed, cluster=2; source annotation_evidence/markers_predicted_doublets_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.247935+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
3	predicted_doublets_removed	3	3141	VSMC	VSMC	supported	Acta2: 99.0% detected, mean 141 versus rest 108; Tagln: 98.3% detected, mean 71.3 versus rest 74; Myh11: 94.0% detected, mean 21 versus rest 14; Cnn1: 43.5% detected, mean 3.18 versus rest 1.95; Entpd1: 23.4% detected, mean 0.762 versus rest 0.629	Other programs remain visible: same-cell pericyte pair and contractile triple 8.8%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	0ab882fbb8e429a6d7aeee080d508c6ff77038c6a421c810ba0ef27a389053bb	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 359/3141 (11.4%); all four pericyte markers: 26/3141 (0.8%); Acta2/Tagln/Myh11: 2930/3141 (93.3%); Cnn1/Entpd1: 444/3141 (14.1%); Plp1/Cnp: 2/3141 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/3141 (0.0%); Pecam1/Cdh5: 0/3141 (0.0%); Ptprc plus a listed subtype marker: 0/3141 (0.0%)	SS: n=43; detection/mean Acta2 100.0%/114, Tagln 95.3%/65.8, Myh11 79.1%/15.8, Cnn1 20.9%/1.86, Entpd1 7.0%/0.228; pericyte pair 16.3%, contractile triple 76.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=13 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/152, Tagln 100.0%/110, Myh11 61.5%/24.7, Cnn1 23.1%/3.24, Entpd1 15.4%/0.673; pericyte pair 7.7%, contractile triple 61.5%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=1436; detection/mean Acta2 98.3%/128, Tagln 97.4%/62.7, Myh11 93.7%/19.7, Cnn1 41.8%/3.1, Entpd1 21.5%/0.731; pericyte pair 11.2%, contractile triple 92.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1649; detection/mean Acta2 99.7%/152, Tagln 99.3%/78.6, Myh11 95.0%/22.3, Cnn1 45.7%/3.29, Entpd1 25.5%/0.804; pericyte pair 11.5%, contractile triple 94.5%, Schwann pair 0.1%, fibroblast pair 0.0%	median detected genes 1486; median mitochondrial fraction 0.0639; predicted doublets 0/3141; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=predicted_doublets_removed, cluster=3; source annotation_evidence/markers_predicted_doublets_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.268583+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
4	predicted_doublets_removed	4	428	Schwann	Schwann	supported	Plp1: 96.7% detected, mean 23.2 versus rest 0.0545; Cnp: 89.0% detected, mean 13.5 versus rest 0.106	Other programs remain visible: same-cell pericyte pair and contractile triple 1.4%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 12.6%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	2f6aa1a71e03f659a4d17e4f746ea3ad70cb06bb6ab9a03f2f74fc995d6bb130	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 13/428 (3.0%); all four pericyte markers: 3/428 (0.7%); Acta2/Tagln/Myh11: 61/428 (14.3%); Cnn1/Entpd1: 10/428 (2.3%); Plp1/Cnp: 375/428 (87.6%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/428 (0.0%); Pecam1/Cdh5: 0/428 (0.0%); Ptprc plus a listed subtype marker: 0/428 (0.0%)	SS: n=117; detection/mean Plp1 94.9%/22.4, Cnp 90.6%/19; pericyte pair 0.9%, contractile triple 6.8%, Schwann pair 87.2%, fibroblast pair 0.0% | D3: n=215; detection/mean Plp1 97.7%/20.1, Cnp 87.0%/8.13; pericyte pair 5.6%, contractile triple 24.7%, Schwann pair 86.5%, fibroblast pair 0.0% | D7: n=35; detection/mean Plp1 94.3%/31.6, Cnp 85.7%/15.4; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 82.9%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1878.5; median mitochondrial fraction 0.0288; predicted doublets 0/428; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=predicted_doublets_removed, cluster=4; source annotation_evidence/markers_predicted_doublets_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.288421+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
5	predicted_doublets_removed	5	127	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 119 versus rest 114; Tagln: 100.0% detected, mean 86.3 versus rest 73.4; Myh11: 96.1% detected, mean 16 versus rest 15.3; Cnn1: 37.0% detected, mean 1.49 versus rest 2.18; Entpd1: 41.7% detected, mean 0.727 versus rest 0.653	Other programs remain visible: same-cell pericyte pair and contractile triple 28.3%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	a09fc403fd82c5b5f248297b6bd2ef58de7d0574e2ebe65584d7cd4997c7b56f	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 40/127 (31.5%); all four pericyte markers: 5/127 (3.9%); Acta2/Tagln/Myh11: 122/127 (96.1%); Cnn1/Entpd1: 26/127 (20.5%); Plp1/Cnp: 0/127 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/127 (0.0%); Pecam1/Cdh5: 0/127 (0.0%); Ptprc plus a listed subtype marker: 0/127 (0.0%)	SS: n=25; detection/mean Acta2 100.0%/114, Tagln 100.0%/66.7, Myh11 92.0%/16.9, Cnn1 36.0%/1.88, Entpd1 24.0%/0.596; pericyte pair 16.0%, contractile triple 92.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=95; detection/mean Acta2 100.0%/123, Tagln 100.0%/94.7, Myh11 97.9%/15.8, Cnn1 36.8%/1.34, Entpd1 48.4%/0.796; pericyte pair 34.7%, contractile triple 97.9%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=2 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/94, Tagln 100.0%/50.5, Myh11 100.0%/17.9, Cnn1 100.0%/3.62, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=5 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/90.3, Tagln 100.0%/38.9, Myh11 80.0%/13.1, Cnn1 20.0%/1.5, Entpd1 20.0%/0.375; pericyte pair 60.0%, contractile triple 80.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2499; median mitochondrial fraction 0.0502; predicted doublets 0/127; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=predicted_doublets_removed, cluster=5; source annotation_evidence/markers_predicted_doublets_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.309184+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
6	predicted_doublets_removed	6	2694	VSMC	VSMC	supported	Acta2: 99.7% detected, mean 122 versus rest 112; Tagln: 99.0% detected, mean 85.4 versus rest 71.3; Myh11: 95.4% detected, mean 16 versus rest 15.1; Cnn1: 25.5% detected, mean 0.975 versus rest 2.4; Entpd1: 40.5% detected, mean 0.867 versus rest 0.613	Other programs remain visible: same-cell pericyte pair and contractile triple 30.8%; pericyte and fibroblast pairs 0.2%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	b02716459d498661a7c16e526ebcdc0dad5cbdf5436738da8edc73a9d4252de3	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 920/2694 (34.1%); all four pericyte markers: 247/2694 (9.2%); Acta2/Tagln/Myh11: 2557/2694 (94.9%); Cnn1/Entpd1: 442/2694 (16.4%); Plp1/Cnp: 5/2694 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 6/2694 (0.2%); Pecam1/Cdh5: 0/2694 (0.0%); Ptprc plus a listed subtype marker: 0/2694 (0.0%)	SS: n=27; detection/mean Acta2 100.0%/93.6, Tagln 81.5%/53.8, Myh11 85.2%/13.9, Cnn1 25.9%/1.17, Entpd1 18.5%/0.298; pericyte pair 48.1%, contractile triple 77.8%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=2662; detection/mean Acta2 99.7%/123, Tagln 99.2%/85.7, Myh11 95.5%/16, Cnn1 25.5%/0.975, Entpd1 40.7%/0.872; pericyte pair 34.0%, contractile triple 95.2%, Schwann pair 0.2%, fibroblast pair 0.2% | D7: n=5 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/113, Tagln 60.0%/69.8, Myh11 100.0%/9.5, Cnn1 0.0%/0, Entpd1 20.0%/0.959; pericyte pair 60.0%, contractile triple 60.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 2290; median mitochondrial fraction 0.0587; predicted doublets 0/2694; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=predicted_doublets_removed, cluster=6; source annotation_evidence/markers_predicted_doublets_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.324993+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
7	predicted_doublets_removed	7	1554	pericyte	pericyte	supported	Kcnj8: 92.7% detected, mean 24.2 versus rest 4; Abcc9: 96.8% detected, mean 21.6 versus rest 1.95; Colec11: 92.7% detected, mean 20.7 versus rest 4.24; Vtn: 92.3% detected, mean 17.8 versus rest 4.6	Other programs remain visible: same-cell pericyte pair and contractile triple 22.6%; pericyte and fibroblast pairs 1.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	caca526c9b531794c2fe1bd3d3d15b53143500d5754671f8bb8e7800f6066fbd	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1522/1554 (97.9%); all four pericyte markers: 1289/1554 (82.9%); Acta2/Tagln/Myh11: 360/1554 (23.2%); Cnn1/Entpd1: 0/1554 (0.0%); Plp1/Cnp: 2/1554 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 15/1554 (1.0%); Pecam1/Cdh5: 0/1554 (0.0%); Ptprc plus a listed subtype marker: 0/1554 (0.0%)	SS: n=16 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 68.8%/17, Abcc9 87.5%/13.4, Colec11 81.2%/17.5, Vtn 75.0%/15.8; pericyte pair 87.5%, contractile triple 25.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1538; detection/mean Kcnj8 92.9%/24.2, Abcc9 96.9%/21.7, Colec11 92.8%/20.7, Vtn 92.5%/17.8; pericyte pair 98.0%, contractile triple 23.1%, Schwann pair 0.1%, fibroblast pair 1.0% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 1746; median mitochondrial fraction 0.0445; predicted doublets 0/1554; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=predicted_doublets_removed, cluster=7; source annotation_evidence/markers_predicted_doublets_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.336134+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
8	predicted_doublets_removed	8	524	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 299 versus rest 108; Tagln: 100.0% detected, mean 240 versus rest 68.3; Myh11: 100.0% detected, mean 35 versus rest 14.6; Cnn1: 99.0% detected, mean 8.64 versus rest 1.97; Entpd1: 75.6% detected, mean 1.4 versus rest 0.63	Other programs remain visible: same-cell pericyte pair and contractile triple 6.9%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.4%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e49880f28257d3b0309bced15a129ee2c6c1f519fa9524b45dc728bd090ee7a5	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 36/524 (6.9%); all four pericyte markers: 6/524 (1.1%); Acta2/Tagln/Myh11: 524/524 (100.0%); Cnn1/Entpd1: 395/524 (75.4%); Plp1/Cnp: 2/524 (0.4%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/524 (0.2%); Pecam1/Cdh5: 0/524 (0.0%); Ptprc plus a listed subtype marker: 0/524 (0.0%)	SS: n=18 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/206, Tagln 100.0%/164, Myh11 100.0%/33.9, Cnn1 88.9%/9.14, Entpd1 38.9%/1.51; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=505; detection/mean Acta2 100.0%/302, Tagln 100.0%/243, Myh11 100.0%/35.1, Cnn1 99.4%/8.6, Entpd1 77.0%/1.4; pericyte pair 7.1%, contractile triple 100.0%, Schwann pair 0.4%, fibroblast pair 0.2% | D7: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/317, Tagln 100.0%/185, Myh11 100.0%/19.8, Cnn1 100.0%/19.8, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 3280.5; median mitochondrial fraction 0.0833; predicted doublets 0/524; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=predicted_doublets_removed, cluster=8; source annotation_evidence/markers_predicted_doublets_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.351362+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
9	predicted_doublets_removed	9	2572	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 164 versus rest 105; Tagln: 100.0% detected, mean 120 versus rest 65.3; Myh11: 99.8% detected, mean 21.1 versus rest 14.2; Cnn1: 61.2% detected, mean 2.75 versus rest 2.07; Entpd1: 58.3% detected, mean 1.19 versus rest 0.558	Other programs remain visible: same-cell pericyte pair and contractile triple 7.0%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	4c8d7b62e66b2e653754ace1500ba1e9f28104096701efefba79836b16ede1f4	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 180/2572 (7.0%); all four pericyte markers: 9/2572 (0.3%); Acta2/Tagln/Myh11: 2566/2572 (99.8%); Cnn1/Entpd1: 1050/2572 (40.8%); Plp1/Cnp: 1/2572 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/2572 (0.0%); Pecam1/Cdh5: 0/2572 (0.0%); Ptprc plus a listed subtype marker: 0/2572 (0.0%)	SS: n=24; detection/mean Acta2 100.0%/150, Tagln 100.0%/95.8, Myh11 100.0%/26.4, Cnn1 79.2%/5.67, Entpd1 41.7%/0.94; pericyte pair 4.2%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=2548; detection/mean Acta2 100.0%/164, Tagln 100.0%/120, Myh11 99.8%/21, Cnn1 61.0%/2.72, Entpd1 58.4%/1.19; pericyte pair 7.0%, contractile triple 99.8%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2595; median mitochondrial fraction 0.0712; predicted doublets 0/2572; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=predicted_doublets_removed, cluster=9; source annotation_evidence/markers_predicted_doublets_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.363562+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
10	predicted_doublets_removed	10	497	pericyte	pericyte	supported	Kcnj8: 78.7% detected, mean 6.07 versus rest 5.83; Abcc9: 87.1% detected, mean 5.64 versus rest 3.68; Colec11: 70.8% detected, mean 5.35 versus rest 5.75; Vtn: 83.9% detected, mean 4.86 versus rest 5.83	Other programs remain visible: same-cell pericyte pair and contractile triple 56.1%; pericyte and fibroblast pairs 10.3%; Schwann pair and contractile triple 0.6%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	c899a8089a8749fbcaa2fdfa38911a36f0b5c7b5992577af11a1d09bc11bb7a0	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 439/497 (88.3%); all four pericyte markers: 298/497 (60.0%); Acta2/Tagln/Myh11: 309/497 (62.2%); Cnn1/Entpd1: 9/497 (1.8%); Plp1/Cnp: 5/497 (1.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 53/497 (10.7%); Pecam1/Cdh5: 0/497 (0.0%); Ptprc plus a listed subtype marker: 0/497 (0.0%)	SS: n=6 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 50.0%/10.1, Abcc9 66.7%/4.33, Colec11 66.7%/10, Vtn 100.0%/21.9; pericyte pair 66.7%, contractile triple 50.0%, Schwann pair 0.0%, fibroblast pair 16.7% | D3: n=457; detection/mean Kcnj8 79.4%/5.95, Abcc9 89.1%/5.82, Colec11 71.3%/5.29, Vtn 84.9%/4.55; pericyte pair 89.3%, contractile triple 63.0%, Schwann pair 0.9%, fibroblast pair 10.7% | D7: n=29; detection/mean Kcnj8 69.0%/5.68, Abcc9 58.6%/2.07, Colec11 62.1%/4.58, Vtn 65.5%/4.65; pericyte pair 75.9%, contractile triple 62.1%, Schwann pair 3.4%, fibroblast pair 10.3% | D42: n=5 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/15, Abcc9 100.0%/11, Colec11 80.0%/9.96, Vtn 80.0%/14.2; pericyte pair 100.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 4321; median mitochondrial fraction 0.0367; predicted doublets 0/497; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=predicted_doublets_removed, cluster=10; source annotation_evidence/markers_predicted_doublets_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.384466+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
11	predicted_doublets_removed	11	253	fibroblast	fibroblast	supported	Pdgfra: 58.1% detected, mean 0.851 versus rest 0.00251; Lum: 96.0% detected, mean 25.6 versus rest 0.0576; Dcn: 99.6% detected, mean 70.7 versus rest 0.573; Cd34: 81.8% detected, mean 3.41 versus rest 0.0253	Other programs remain visible: same-cell pericyte pair and contractile triple 2.0%; pericyte and fibroblast pairs 7.1%; Schwann pair and contractile triple 1.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	f6a80c59cc9a8f21a2915e2da55f163ce12aee9cc6025f11e989963655766208	SCP002-A001	accepted_versioned_annotation_decision	F	at least two of Kcnj8/Abcc9/Colec11/Vtn: 18/253 (7.1%); all four pericyte markers: 4/253 (1.6%); Acta2/Tagln/Myh11: 46/253 (18.2%); Cnn1/Entpd1: 3/253 (1.2%); Plp1/Cnp: 3/253 (1.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 252/253 (99.6%); Pecam1/Cdh5: 0/253 (0.0%); Ptprc plus a listed subtype marker: 0/253 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=82; detection/mean Pdgfra 76.8%/0.923, Lum 92.7%/6.54, Dcn 98.8%/21, Cd34 74.4%/1.32; pericyte pair 14.6%, contractile triple 43.9%, Schwann pair 1.2%, fibroblast pair 98.8% | D7: n=164; detection/mean Pdgfra 48.8%/0.768, Lum 97.6%/33.4, Dcn 100.0%/89.7, Cd34 85.4%/4.33; pericyte pair 3.7%, contractile triple 6.1%, Schwann pair 1.2%, fibroblast pair 100.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Pdgfra 57.1%/1.96, Lum 100.0%/66.5, Dcn 100.0%/206, Cd34 85.7%/6.26; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 100.0%	median detected genes 3432; median mitochondrial fraction 0.0239; predicted doublets 0/253; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=predicted_doublets_removed, cluster=11; source annotation_evidence/markers_predicted_doublets_removed/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.399416+00:00	supported	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	supported_broad_identity_retained
0	primary	0	2924	VSMC	VSMC	supported	Acta2: 99.8% detected, mean 155 versus rest 105; Tagln: 99.5% detected, mean 95.9 versus rest 68.9; Myh11: 97.6% detected, mean 22.8 versus rest 13.7; Cnn1: 50.8% detected, mean 3.67 versus rest 1.86; Entpd1: 29.4% detected, mean 0.796 versus rest 0.624	Other programs remain visible: same-cell pericyte pair and contractile triple 7.4%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	ffd6e3921e2776a1f1ba749b0cde1ede1b0884cebc266a87c126214de6af1a03	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 255/2924 (8.7%); all four pericyte markers: 17/2924 (0.6%); Acta2/Tagln/Myh11: 2840/2924 (97.1%); Cnn1/Entpd1: 547/2924 (18.7%); Plp1/Cnp: 3/2924 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2924 (0.0%); Pecam1/Cdh5: 0/2924 (0.0%); Ptprc plus a listed subtype marker: 0/2924 (0.0%)	SS: n=2861; detection/mean Acta2 99.8%/154, Tagln 99.4%/95.5, Myh11 97.7%/22.7, Cnn1 50.9%/3.67, Entpd1 29.4%/0.79; pericyte pair 8.8%, contractile triple 97.2%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=46; detection/mean Acta2 100.0%/179, Tagln 100.0%/120, Myh11 91.3%/27.1, Cnn1 41.3%/3.16, Entpd1 32.6%/1.26; pericyte pair 6.5%, contractile triple 91.3%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=13 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/164, Tagln 100.0%/108, Myh11 100.0%/35.4, Cnn1 61.5%/7.16, Entpd1 15.4%/0.399; pericyte pair 7.7%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=4 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/216, Tagln 100.0%/89.4, Myh11 100.0%/34.4, Cnn1 50.0%/4.01, Entpd1 75.0%/1.42; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1815; median mitochondrial fraction 0.0603; predicted doublets 7/2924; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=primary, cluster=0; source annotation_evidence/markers_primary/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.426758+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
1	primary	1	1102	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 258 versus rest 104; Tagln: 100.0% detected, mean 200 versus rest 64.8; Myh11: 100.0% detected, mean 31.7 versus rest 14.1; Cnn1: 96.4% detected, mean 6.96 versus rest 1.84; Entpd1: 73.4% detected, mean 1.37 versus rest 0.604	Other programs remain visible: same-cell pericyte pair and contractile triple 5.4%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	1560b03c7d60fb47f8e5baf40372c45611fb86ca6802309147c73bb0429b53b4	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 59/1102 (5.4%); all four pericyte markers: 8/1102 (0.7%); Acta2/Tagln/Myh11: 1102/1102 (100.0%); Cnn1/Entpd1: 787/1102 (71.4%); Plp1/Cnp: 2/1102 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/1102 (0.1%); Pecam1/Cdh5: 0/1102 (0.0%); Ptprc plus a listed subtype marker: 0/1102 (0.0%)	SS: n=28; detection/mean Acta2 100.0%/209, Tagln 100.0%/162, Myh11 100.0%/32.8, Cnn1 92.9%/9.71, Entpd1 35.7%/1.24; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1074; detection/mean Acta2 100.0%/259, Tagln 100.0%/201, Myh11 100.0%/31.6, Cnn1 96.5%/6.89, Entpd1 74.4%/1.38; pericyte pair 5.5%, contractile triple 100.0%, Schwann pair 0.2%, fibroblast pair 0.1% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 3101; median mitochondrial fraction 0.0847; predicted doublets 0/1102; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=primary, cluster=1; source annotation_evidence/markers_primary/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.441316+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
2	primary	2	2805	VSMC	VSMC	supported	Acta2: 99.5% detected, mean 148 versus rest 107; Tagln: 99.0% detected, mean 75.2 versus rest 73.2; Myh11: 95.7% detected, mean 22.3 versus rest 13.9; Cnn1: 48.4% detected, mean 3.59 versus rest 1.9; Entpd1: 25.6% detected, mean 0.837 versus rest 0.617	Other programs remain visible: same-cell pericyte pair and contractile triple 6.4%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	a02b40a2a2f480ef863db574220a0d268f4f689f5a07fb73b75bc12784bbd808	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 207/2805 (7.4%); all four pericyte markers: 13/2805 (0.5%); Acta2/Tagln/Myh11: 2673/2805 (95.3%); Cnn1/Entpd1: 451/2805 (16.1%); Plp1/Cnp: 1/2805 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2805 (0.0%); Pecam1/Cdh5: 0/2805 (0.0%); Ptprc plus a listed subtype marker: 0/2805 (0.0%)	SS: n=41; detection/mean Acta2 100.0%/159, Tagln 97.6%/93.8, Myh11 92.7%/23.2, Cnn1 36.6%/4.91, Entpd1 19.5%/0.72; pericyte pair 4.9%, contractile triple 90.2%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=12 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/160, Tagln 100.0%/117, Myh11 58.3%/25, Cnn1 25.0%/4.45, Entpd1 16.7%/0.73; pericyte pair 8.3%, contractile triple 58.3%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=1344; detection/mean Acta2 99.2%/132, Tagln 98.5%/65.3, Myh11 95.1%/20.6, Cnn1 44.3%/3.3, Entpd1 22.5%/0.774; pericyte pair 8.3%, contractile triple 94.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1408; detection/mean Acta2 99.9%/162, Tagln 99.6%/83.7, Myh11 96.7%/23.9, Cnn1 52.8%/3.82, Entpd1 28.7%/0.901; pericyte pair 6.6%, contractile triple 96.4%, Schwann pair 0.1%, fibroblast pair 0.0%	median detected genes 1499; median mitochondrial fraction 0.0674; predicted doublets 4/2805; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=primary, cluster=2; source annotation_evidence/markers_primary/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.462037+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
3	primary	3	1442	pericyte	pericyte	supported	Kcnj8: 75.2% detected, mean 8.03 versus rest 5.64; Abcc9: 75.7% detected, mean 4.67 versus rest 3.66; Colec11: 84.2% detected, mean 16.6 versus rest 4.73; Vtn: 87.4% detected, mean 14.1 versus rest 5.04	Other programs remain visible: same-cell pericyte pair and contractile triple 47.2%; pericyte and fibroblast pairs 9.2%; Schwann pair and contractile triple 0.3%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. The four pericyte genes each occur in 75-87% of cells; 91.7% express at least two. Dcn expression occurs in 51%, but Pdgfra in only 1% and Pdgfra/Lum together in 0.5%. Pericyte identity is compatible with this partial matrix and contractile program; it does not establish fibroblast conversion or a new activated subtype.	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	111f0b03cab5efd2caa973dbfa344fe7ef6cfb7e20187709a3b4ac2a2f8a8380	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1322/1442 (91.7%); all four pericyte markers: 795/1442 (55.1%); Acta2/Tagln/Myh11: 750/1442 (52.0%); Cnn1/Entpd1: 29/1442 (2.0%); Plp1/Cnp: 7/1442 (0.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 159/1442 (11.0%); Pecam1/Cdh5: 0/1442 (0.0%); Ptprc plus a listed subtype marker: 0/1442 (0.0%)	SS: n=83; detection/mean Kcnj8 59.0%/6.02, Abcc9 47.0%/2.03, Colec11 80.7%/19.8, Vtn 75.9%/24.3; pericyte pair 78.3%, contractile triple 67.5%, Schwann pair 0.0%, fibroblast pair 15.7% | D3: n=599; detection/mean Kcnj8 74.5%/4.59, Abcc9 86.8%/4.97, Colec11 73.0%/5.78, Vtn 86.6%/6.32; pericyte pair 89.6%, contractile triple 70.8%, Schwann pair 0.8%, fibroblast pair 13.0% | D7: n=539; detection/mean Kcnj8 79.2%/11.3, Abcc9 75.1%/5.15, Colec11 92.8%/22.8, Vtn 87.2%/14.5; pericyte pair 94.4%, contractile triple 32.5%, Schwann pair 0.4%, fibroblast pair 10.4% | D42: n=221; detection/mean Kcnj8 73.8%/9.99, Abcc9 57.5%/3.7, Colec11 95.0%/30, Vtn 94.1%/30.6; pericyte pair 95.5%, contractile triple 43.0%, Schwann pair 0.0%, fibroblast pair 5.4%	median detected genes 2406.5; median mitochondrial fraction 0.0327; predicted doublets 3/1442; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=primary, cluster=3; source annotation_evidence/markers_primary/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.484743+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. The four pericyte genes each occur in 75-87% of cells; 91.7% express at least two. Dcn expression occurs in 51%, but Pdgfra in only 1% and Pdgfra/Lum together in 0.5%. Pericyte identity is compatible with this partial matrix and contractile program; it does not establish fibroblast conversion or a new activated subtype.	supported_broad_identity_retained
4	primary	4	1700	pericyte	pericyte	supported	Kcnj8: 77.2% detected, mean 26.7 versus rest 3.54; Abcc9: 72.6% detected, mean 10.6 versus rest 2.98; Colec11: 84.7% detected, mean 20.2 versus rest 4.14; Vtn: 85.2% detected, mean 22.3 versus rest 3.99	Other programs remain visible: same-cell pericyte pair and contractile triple 15.4%; pericyte and fibroblast pairs 0.3%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	a850998f565eba854293426a3eb7f144915fb54b1c748c922a450af9779e320f	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1492/1700 (87.8%); all four pericyte markers: 1001/1700 (58.9%); Acta2/Tagln/Myh11: 410/1700 (24.1%); Cnn1/Entpd1: 0/1700 (0.0%); Plp1/Cnp: 3/1700 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 6/1700 (0.4%); Pecam1/Cdh5: 0/1700 (0.0%); Ptprc plus a listed subtype marker: 0/1700 (0.0%)	SS: n=361; detection/mean Kcnj8 90.9%/26.7, Abcc9 83.9%/12.3, Colec11 93.4%/22, Vtn 94.7%/26.5; pericyte pair 97.2%, contractile triple 14.4%, Schwann pair 0.0%, fibroblast pair 0.3% | D3: n=64; detection/mean Kcnj8 67.2%/22.1, Abcc9 57.8%/13.4, Colec11 71.9%/18, Vtn 68.8%/17.8; pericyte pair 81.2%, contractile triple 14.1%, Schwann pair 0.0%, fibroblast pair 1.6% | D7: n=355; detection/mean Kcnj8 76.1%/27, Abcc9 70.4%/9.55, Colec11 87.0%/22.1, Vtn 87.3%/25; pericyte pair 89.0%, contractile triple 21.1%, Schwann pair 0.0%, fibroblast pair 0.6% | D42: n=920; detection/mean Kcnj8 72.9%/26.9, Abcc9 70.1%/10.2, Colec11 81.3%/18.9, Vtn 81.7%/19.8; pericyte pair 84.0%, contractile triple 29.8%, Schwann pair 0.3%, fibroblast pair 0.2%	median detected genes 1257; median mitochondrial fraction 0.0326; predicted doublets 7/1700; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=primary, cluster=4; source annotation_evidence/markers_primary/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.505610+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
5	primary	5	2784	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 127 versus rest 111; Tagln: 99.0% detected, mean 88.5 versus rest 70.6; Myh11: 96.0% detected, mean 16.7 versus rest 15; Cnn1: 28.8% detected, mean 1.13 versus rest 2.38; Entpd1: 42.2% detected, mean 0.914 versus rest 0.603	Other programs remain visible: same-cell pericyte pair and contractile triple 28.7%; pericyte and fibroblast pairs 0.2%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. The dominant D3 component has 95.7% contractile-triple detection versus 31.3% with two pericyte markers. The SS subset is only 30 cells and has 40.0% all-four pericyte detection, so minority heterogeneity is explicit. This broad VSMC assignment is not a claim that the cluster is homogeneous.	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	654d65f810329dadc1745842a6b36d49bfc475a0bdd60f4d8114fa912e3135d4	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 878/2784 (31.5%); all four pericyte markers: 241/2784 (8.7%); Acta2/Tagln/Myh11: 2660/2784 (95.5%); Cnn1/Entpd1: 519/2784 (18.6%); Plp1/Cnp: 5/2784 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 6/2784 (0.2%); Pecam1/Cdh5: 0/2784 (0.0%); Ptprc plus a listed subtype marker: 0/2784 (0.0%)	SS: n=30; detection/mean Acta2 100.0%/103, Tagln 90.0%/60.1, Myh11 93.3%/15.4, Cnn1 33.3%/1.34, Entpd1 20.0%/0.357; pericyte pair 50.0%, contractile triple 86.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=2749; detection/mean Acta2 99.9%/127, Tagln 99.1%/88.8, Myh11 96.0%/16.7, Cnn1 28.8%/1.13, Entpd1 42.5%/0.92; pericyte pair 31.3%, contractile triple 95.7%, Schwann pair 0.2%, fibroblast pair 0.2% | D7: n=5 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/113, Tagln 60.0%/69.8, Myh11 100.0%/9.5, Cnn1 0.0%/0, Entpd1 20.0%/0.959; pericyte pair 60.0%, contractile triple 60.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 2312; median mitochondrial fraction 0.061; predicted doublets 11/2784; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=primary, cluster=5; source annotation_evidence/markers_primary/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.521927+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. The dominant D3 component has 95.7% contractile-triple detection versus 31.3% with two pericyte markers. The SS subset is only 30 cells and has 40.0% all-four pericyte detection, so minority heterogeneity is explicit. This broad VSMC assignment is not a claim that the cluster is homogeneous.	supported_broad_identity_retained
6	primary	6	432	Schwann	Schwann	supported	Plp1: 96.8% detected, mean 23 versus rest 0.0544; Cnp: 88.9% detected, mean 13.4 versus rest 0.106	Other programs remain visible: same-cell pericyte pair and contractile triple 1.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 13.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e6f997da9513413875ba350696d03eb9becd30a955298bb06266857351585789	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 14/432 (3.2%); all four pericyte markers: 3/432 (0.7%); Acta2/Tagln/Myh11: 64/432 (14.8%); Cnn1/Entpd1: 10/432 (2.3%); Plp1/Cnp: 378/432 (87.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/432 (0.0%); Pecam1/Cdh5: 0/432 (0.0%); Ptprc plus a listed subtype marker: 0/432 (0.0%)	SS: n=121; detection/mean Plp1 95.0%/22, Cnp 90.1%/18.5; pericyte pair 1.7%, contractile triple 9.1%, Schwann pair 86.8%, fibroblast pair 0.0% | D3: n=215; detection/mean Plp1 97.7%/20.1, Cnp 87.0%/8.13; pericyte pair 5.6%, contractile triple 24.7%, Schwann pair 86.5%, fibroblast pair 0.0% | D7: n=35; detection/mean Plp1 94.3%/31.6, Cnp 85.7%/15.4; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 82.9%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1888; median mitochondrial fraction 0.0288; predicted doublets 4/432; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=primary, cluster=6; source annotation_evidence/markers_primary/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.541582+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
7	primary	7	1897	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 144 versus rest 110; Tagln: 100.0% detected, mean 105 versus rest 69.6; Myh11: 99.6% detected, mean 18.1 versus rest 14.9; Cnn1: 48.7% detected, mean 1.83 versus rest 2.22; Entpd1: 53.1% detected, mean 1.09 versus rest 0.598	Other programs remain visible: same-cell pericyte pair and contractile triple 9.8%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	7cef9705106051fe7fe2dfa25788305cbd7dc16d4b2b278b2e6c34ad619e4c20	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 186/1897 (9.8%); all four pericyte markers: 12/1897 (0.6%); Acta2/Tagln/Myh11: 1889/1897 (99.6%); Cnn1/Entpd1: 587/1897 (30.9%); Plp1/Cnp: 1/1897 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/1897 (0.1%); Pecam1/Cdh5: 0/1897 (0.0%); Ptprc plus a listed subtype marker: 0/1897 (0.0%)	SS: n=16 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/147, Tagln 100.0%/85.2, Myh11 100.0%/25.7, Cnn1 75.0%/5.16, Entpd1 31.2%/0.581; pericyte pair 6.2%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1881; detection/mean Acta2 100.0%/144, Tagln 100.0%/105, Myh11 99.6%/18.1, Cnn1 48.5%/1.8, Entpd1 53.3%/1.1; pericyte pair 9.8%, contractile triple 99.6%, Schwann pair 0.1%, fibroblast pair 0.1% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2491; median mitochondrial fraction 0.0647; predicted doublets 0/1897; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=primary, cluster=7; source annotation_evidence/markers_primary/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.552770+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
8	primary	8	1593	pericyte	pericyte	supported	Kcnj8: 92.8% detected, mean 24 versus rest 3.97; Abcc9: 96.8% detected, mean 21.4 versus rest 1.93; Colec11: 92.7% detected, mean 20.6 versus rest 4.22; Vtn: 92.4% detected, mean 17.8 versus rest 4.57	Other programs remain visible: same-cell pericyte pair and contractile triple 22.6%; pericyte and fibroblast pairs 1.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 1571 of 1593 cells are from D3, but time enrichment is not used to assign an activated state. Four-marker pericyte concordance and weak Cnn1/Entpd1 support the broad identity; there are only 22 SS cells and no D7/D42 cells in this particular cluster.	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	c7eed362c90e709406c5c1ce0c055b4532c6a8bb2462e6815d54f87b96861cd9	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1564/1593 (98.2%); all four pericyte markers: 1317/1593 (82.7%); Acta2/Tagln/Myh11: 369/1593 (23.2%); Cnn1/Entpd1: 0/1593 (0.0%); Plp1/Cnp: 2/1593 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 16/1593 (1.0%); Pecam1/Cdh5: 0/1593 (0.0%); Ptprc plus a listed subtype marker: 0/1593 (0.0%)	SS: n=22; detection/mean Kcnj8 86.4%/19.4, Abcc9 90.9%/13.8, Colec11 90.9%/17.8, Vtn 86.4%/21.2; pericyte pair 95.5%, contractile triple 18.2%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1571; detection/mean Kcnj8 92.9%/24.1, Abcc9 96.9%/21.5, Colec11 92.7%/20.6, Vtn 92.5%/17.7; pericyte pair 98.2%, contractile triple 23.2%, Schwann pair 0.1%, fibroblast pair 1.0% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 1747; median mitochondrial fraction 0.0443; predicted doublets 0/1593; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=primary, cluster=8; source annotation_evidence/markers_primary/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.563871+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 1571 of 1593 cells are from D3, but time enrichment is not used to assign an activated state. Four-marker pericyte concordance and weak Cnn1/Entpd1 support the broad identity; there are only 22 SS cells and no D7/D42 cells in this particular cluster.	supported_broad_identity_retained
9	primary	9	172	VSMC	VSMC	supported	Acta2: 98.3% detected, mean 114 versus rest 114; Tagln: 98.3% detected, mean 75.1 versus rest 73.5; Myh11: 93.0% detected, mean 15.2 versus rest 15.3; Cnn1: 32.0% detected, mean 1.36 versus rest 2.18; Entpd1: 30.2% detected, mean 0.582 versus rest 0.654	Other programs remain visible: same-cell pericyte pair and contractile triple 25.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. Small group (172 cells) but the contractile triple is present in 93.0%; all-four pericyte detection is 4.1%. Inspect library-specific shifts rather than treating this as a distinct VSMC subtype.	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	45c9f01f0fe53c345ec8ae216492f318355e5426a5e5f942c40a507d14bddef4	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 51/172 (29.7%); all four pericyte markers: 7/172 (4.1%); Acta2/Tagln/Myh11: 160/172 (93.0%); Cnn1/Entpd1: 24/172 (14.0%); Plp1/Cnp: 0/172 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/172 (0.0%); Pecam1/Cdh5: 0/172 (0.0%); Ptprc plus a listed subtype marker: 0/172 (0.0%)	SS: n=31; detection/mean Acta2 100.0%/106, Tagln 100.0%/66.9, Myh11 93.5%/15.9, Cnn1 29.0%/1.52, Entpd1 19.4%/0.481; pericyte pair 22.6%, contractile triple 93.5%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=86; detection/mean Acta2 100.0%/123, Tagln 100.0%/95.8, Myh11 100.0%/16.7, Cnn1 37.2%/1.37, Entpd1 50.0%/0.827; pericyte pair 34.9%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=16 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 93.8%/98.2, Tagln 93.8%/37.6, Myh11 87.5%/10.5, Cnn1 31.2%/1.71, Entpd1 0.0%/0; pericyte pair 6.2%, contractile triple 87.5%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=39; detection/mean Acta2 94.9%/109, Tagln 94.9%/51.6, Myh11 79.5%/13.6, Cnn1 23.1%/1.08, Entpd1 7.7%/0.36; pericyte pair 33.3%, contractile triple 79.5%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2040.5; median mitochondrial fraction 0.0497; predicted doublets 0/172; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=primary, cluster=9; source annotation_evidence/markers_primary/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.583698+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. Small group (172 cells) but the contractile triple is present in 93.0%; all-four pericyte detection is 4.1%. Inspect library-specific shifts rather than treating this as a distinct VSMC subtype.	supported_broad_identity_retained
10	primary	10	256	fibroblast	fibroblast	supported	Pdgfra: 57.4% detected, mean 0.841 versus rest 0.0025; Lum: 95.7% detected, mean 25.3 versus rest 0.0568; Dcn: 99.6% detected, mean 70.4 versus rest 0.565; Cd34: 81.2% detected, mean 3.37 versus rest 0.0251	Other programs remain visible: same-cell pericyte pair and contractile triple 2.3%; pericyte and fibroblast pairs 7.8%; Schwann pair and contractile triple 1.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	a0d1f97aa4d10a51c9d87ef6037d3a957971bf86235a6b15c00ad7f7116b6f48	SCP002-A001	accepted_versioned_annotation_decision	F	at least two of Kcnj8/Abcc9/Colec11/Vtn: 20/256 (7.8%); all four pericyte markers: 4/256 (1.6%); Acta2/Tagln/Myh11: 47/256 (18.4%); Cnn1/Entpd1: 3/256 (1.2%); Plp1/Cnp: 3/256 (1.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 255/256 (99.6%); Pecam1/Cdh5: 0/256 (0.0%); Ptprc plus a listed subtype marker: 0/256 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=82; detection/mean Pdgfra 76.8%/0.923, Lum 92.7%/6.54, Dcn 98.8%/21, Cd34 74.4%/1.32; pericyte pair 14.6%, contractile triple 43.9%, Schwann pair 1.2%, fibroblast pair 98.8% | D7: n=167; detection/mean Pdgfra 47.9%/0.755, Lum 97.0%/32.8, Dcn 100.0%/88.9, Cd34 84.4%/4.26; pericyte pair 4.8%, contractile triple 6.6%, Schwann pair 1.2%, fibroblast pair 100.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Pdgfra 57.1%/1.96, Lum 100.0%/66.5, Dcn 100.0%/206, Cd34 85.7%/6.26; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 100.0%	median detected genes 3424.5; median mitochondrial fraction 0.0239; predicted doublets 0/256; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=primary, cluster=10; source annotation_evidence/markers_primary/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.599842+00:00	supported	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	supported_broad_identity_retained
0	resolution_025	0	2921	VSMC	VSMC	supported	Acta2: 99.8% detected, mean 155 versus rest 105; Tagln: 99.6% detected, mean 96.4 versus rest 68.8; Myh11: 97.7% detected, mean 22.8 versus rest 13.7; Cnn1: 51.1% detected, mean 3.73 versus rest 1.85; Entpd1: 29.6% detected, mean 0.805 versus rest 0.622	Other programs remain visible: same-cell pericyte pair and contractile triple 7.3%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	a691fe81c1307173b2b16facd6a7a4edc3c8136d073b27ace1db93a2072871ed	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 252/2921 (8.6%); all four pericyte markers: 15/2921 (0.5%); Acta2/Tagln/Myh11: 2842/2921 (97.3%); Cnn1/Entpd1: 552/2921 (18.9%); Plp1/Cnp: 3/2921 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2921 (0.0%); Pecam1/Cdh5: 0/2921 (0.0%); Ptprc plus a listed subtype marker: 0/2921 (0.0%)	SS: n=2865; detection/mean Acta2 99.8%/155, Tagln 99.5%/96, Myh11 97.8%/22.7, Cnn1 51.2%/3.72, Entpd1 29.5%/0.794; pericyte pair 8.7%, contractile triple 97.3%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=41; detection/mean Acta2 100.0%/181, Tagln 100.0%/121, Myh11 92.7%/27.5, Cnn1 43.9%/3.36, Entpd1 34.1%/1.36; pericyte pair 4.9%, contractile triple 92.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=12 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/126, Tagln 100.0%/99.8, Myh11 100.0%/36, Cnn1 58.3%/7.14, Entpd1 33.3%/1.34; pericyte pair 8.3%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=3 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/176, Tagln 100.0%/53.4, Myh11 100.0%/30.1, Cnn1 33.3%/3.49, Entpd1 66.7%/1.43; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1816; median mitochondrial fraction 0.0603; predicted doublets 7/2921; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_025, cluster=0; source annotation_evidence/markers_resolution_025/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.619993+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
1	resolution_025	1	3114	VSMC	VSMC	supported	Acta2: 99.2% detected, mean 142 versus rest 108; Tagln: 98.4% detected, mean 71.9 versus rest 73.9; Myh11: 94.3% detected, mean 21.2 versus rest 13.9; Cnn1: 44.0% detected, mean 3.22 versus rest 1.94; Entpd1: 23.6% detected, mean 0.768 versus rest 0.628	Other programs remain visible: same-cell pericyte pair and contractile triple 8.2%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	235a10f2a121c01c75cfa78cb031adb41277e1785262ba0cbba71a2e26852472	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 325/3114 (10.4%); all four pericyte markers: 20/3114 (0.6%); Acta2/Tagln/Myh11: 2911/3114 (93.5%); Cnn1/Entpd1: 446/3114 (14.3%); Plp1/Cnp: 1/3114 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/3114 (0.0%); Pecam1/Cdh5: 0/3114 (0.0%); Ptprc plus a listed subtype marker: 0/3114 (0.0%)	SS: n=58; detection/mean Acta2 98.3%/106, Tagln 91.4%/62.8, Myh11 81.0%/17.2, Cnn1 19.0%/1.76, Entpd1 6.9%/0.201; pericyte pair 15.5%, contractile triple 74.1%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=16 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/133, Tagln 93.8%/93.9, Myh11 50.0%/20.1, Cnn1 18.8%/2.63, Entpd1 12.5%/0.547; pericyte pair 6.2%, contractile triple 50.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=1405; detection/mean Acta2 98.6%/130, Tagln 97.8%/63.7, Myh11 94.3%/20.1, Cnn1 42.6%/3.16, Entpd1 21.9%/0.745; pericyte pair 9.5%, contractile triple 93.5%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1635; detection/mean Acta2 99.8%/153, Tagln 99.2%/79, Myh11 95.1%/22.4, Cnn1 46.2%/3.32, Entpd1 25.8%/0.811; pericyte pair 11.1%, contractile triple 94.6%, Schwann pair 0.1%, fibroblast pair 0.0%	median detected genes 1485; median mitochondrial fraction 0.0644; predicted doublets 6/3114; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_025, cluster=1; source annotation_evidence/markers_resolution_025/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.646923+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
2	resolution_025	2	2386	pericyte	pericyte	supported	Kcnj8: 82.6% detected, mean 22.6 versus rest 3.11; Abcc9: 77.2% detected, mean 9.11 versus rest 2.87; Colec11: 91.8% detected, mean 23 versus rest 2.93; Vtn: 90.2% detected, mean 23.1 versus rest 3	Other programs remain visible: same-cell pericyte pair and contractile triple 24.4%; pericyte and fibroblast pairs 3.7%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	31627e20050f180cfd8f3efc7ca23516e436a828872252b5ac99cc4e498427f9	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 2271/2386 (95.2%); all four pericyte markers: 1499/2386 (62.8%); Acta2/Tagln/Myh11: 638/2386 (26.7%); Cnn1/Entpd1: 19/2386 (0.8%); Plp1/Cnp: 5/2386 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 114/2386 (4.8%); Pecam1/Cdh5: 0/2386 (0.0%); Ptprc plus a listed subtype marker: 0/2386 (0.0%)	SS: n=432; detection/mean Kcnj8 86.8%/23.3, Abcc9 78.5%/10.6, Colec11 92.6%/22, Vtn 91.4%/26.3; pericyte pair 95.1%, contractile triple 24.5%, Schwann pair 0.0%, fibroblast pair 3.0% | D3: n=190; detection/mean Kcnj8 66.8%/9.21, Abcc9 76.3%/6.46, Colec11 82.1%/12.5, Vtn 87.4%/15.5; pericyte pair 92.6%, contractile triple 64.2%, Schwann pair 0.5%, fibroblast pair 15.8% | D7: n=819; detection/mean Kcnj8 81.6%/19, Abcc9 76.8%/7.37, Colec11 94.1%/24.2, Vtn 89.3%/20; pericyte pair 95.6%, contractile triple 24.5%, Schwann pair 0.1%, fibroblast pair 7.0% | D42: n=945; detection/mean Kcnj8 84.7%/28.2, Abcc9 77.1%/10.5, Colec11 91.4%/24.7, Vtn 91.1%/25.9; pericyte pair 95.3%, contractile triple 22.1%, Schwann pair 0.3%, fibroblast pair 1.5%	median detected genes 1447.5; median mitochondrial fraction 0.0311; predicted doublets 8/2386; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_025, cluster=2; source annotation_evidence/markers_resolution_025/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.671675+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
3	resolution_025	3	787	unassigned	unassigned	mixed	Kcnj8: 54.6% detected, mean 3.4 versus rest 5.96; Abcc9: 60.5% detected, mean 3.37 versus rest 3.76; Colec11: 52.5% detected, mean 3.06 versus rest 5.87; Vtn: 60.0% detected, mean 2.89 versus rest 5.94; Myh11: 52.6% detected, mean 2.08 versus rest 15.9; Cnn1: 16.5% detected, mean 0.317 versus rest 2.26; Entpd1: 5.0% detected, mean 0.0667 versus rest 0.682; Pdgfra: 19.3% detected, mean 0.28 versus rest 0.00227; Lum: 37.2% detected, mean 8.35 versus rest 0.0536; Dcn: 58.4% detected, mean 23.6 versus rest 0.548; Cd34: 29.4% detected, mean 1.12 versus rest 0.0247	Other programs remain visible: same-cell pericyte pair and contractile triple 41.7%; pericyte and fibroblast pairs 8.9%; Schwann pair and contractile triple 0.8%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A substantial pericyte-marker subgroup and a substantial fibroblast-marker subgroup occupy this coarse cluster, with much less overlap between the two programs than either program alone. D3 is predominantly pericyte-like whereas D7 is predominantly fibroblast-like. This is chiefly evidence of a merged heterogeneous cluster, not proof that individual cells transdifferentiate. Do not relabel the entire cluster as pericytes or fibroblasts; retain unassigned cells and the resulting sensitivity consequence. Of 787 cells, 484 meet the two-pericyte-marker descriptive conjunction and 306 meet the two-fibroblast-marker conjunction, but only 70 meet both. D3 has 77.7% pericyte-conjunction and 22.7% fibroblast-conjunction detection; D7 has 15.3% and 85.7%. This same-cell and per-library evidence supports a mixed cluster, not a homogeneous dual-state label.	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	7de4377a7320448ee7d4698e70f09faaa11cfcb0ef611859f2078f35b0303c6c	SCP002-A001	accepted_versioned_annotation_decision	X	at least two of Kcnj8/Abcc9/Colec11/Vtn: 484/787 (61.5%); all four pericyte markers: 308/787 (39.1%); Acta2/Tagln/Myh11: 409/787 (52.0%); Cnn1/Entpd1: 15/787 (1.9%); Plp1/Cnp: 8/787 (1.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 306/787 (38.9%); Pecam1/Cdh5: 0/787 (0.0%); Ptprc plus a listed subtype marker: 0/787 (0.0%)	SS: n=6 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 50.0%/10.1, Abcc9 66.7%/4.33, Colec11 66.7%/10, Vtn 100.0%/21.9, Myh11 50.0%/1.69, Cnn1 0.0%/0, Entpd1 16.7%/0.195, Pdgfra 0.0%/0, Lum 0.0%/0, Dcn 33.3%/1.81, Cd34 33.3%/0.855; pericyte pair 66.7%, contractile triple 50.0%, Schwann pair 0.0%, fibroblast pair 16.7% | D3: n=573; detection/mean Kcnj8 68.1%/4.11, Abcc9 77.3%/4.37, Colec11 63.2%/3.73, Vtn 74.7%/3.35, Myh11 65.8%/2.65, Cnn1 19.7%/0.392, Entpd1 6.5%/0.0879, Pdgfra 11.7%/0.138, Lum 21.3%/1.08, Dcn 47.3%/4.03, Cd34 14.1%/0.217; pericyte pair 77.7%, contractile triple 65.4%, Schwann pair 0.9%, fibroblast pair 22.7% | D7: n=196; detection/mean Kcnj8 16.3%/0.922, Abcc9 11.7%/0.337, Colec11 21.9%/0.834, Vtn 17.3%/0.775, Myh11 17.3%/0.547, Cnn1 8.7%/0.128, Entpd1 0.5%/0.00481, Pdgfra 41.3%/0.65, Lum 83.7%/28, Dcn 91.3%/75.6, Cd34 72.4%/3.63; pericyte pair 15.3%, contractile triple 15.8%, Schwann pair 1.5%, fibroblast pair 85.7% | D42: n=12 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 41.7%/6.25, Abcc9 50.0%/4.71, Colec11 33.3%/4.15, Vtn 33.3%/5.9, Myh11 0.0%/0, Cnn1 0.0%/0, Entpd1 0.0%/0, Pdgfra 33.3%/1.14, Lum 58.3%/38.8, Dcn 66.7%/121, Cd34 50.0%/3.65; pericyte pair 41.7%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 58.3%	median detected genes 3961; median mitochondrial fraction 0.0325; predicted doublets 0/787; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_025, cluster=3; source annotation_evidence/markers_resolution_025/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.692005+00:00	mixed	A substantial pericyte-marker subgroup and a substantial fibroblast-marker subgroup occupy this coarse cluster, with much less overlap between the two programs than either program alone. D3 is predominantly pericyte-like whereas D7 is predominantly fibroblast-like. This is chiefly evidence of a merged heterogeneous cluster, not proof that individual cells transdifferentiate. Do not relabel the entire cluster as pericytes or fibroblasts; retain unassigned cells and the resulting sensitivity consequence. Of 787 cells, 484 meet the two-pericyte-marker descriptive conjunction and 306 meet the two-fibroblast-marker conjunction, but only 70 meet both. D3 has 77.7% pericyte-conjunction and 22.7% fibroblast-conjunction detection; D7 has 15.3% and 85.7%. This same-cell and per-library evidence supports a mixed cluster, not a homogeneous dual-state label.	proposal_uncertainty_retained
4	resolution_025	4	5833	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 158 versus rest 91.2; Tagln: 99.7% detected, mean 115 versus rest 51.9; Myh11: 98.3% detected, mean 20.1 versus rest 12.7; Cnn1: 48.5% detected, mean 2.48 versus rest 2.02; Entpd1: 52.0% detected, mean 1.07 versus rest 0.439	Other programs remain visible: same-cell pericyte pair and contractile triple 17.8%; pericyte and fibroblast pairs 0.1%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	7be5f9278bb42ba6c4650902c20f067b6c1afdb0a04e2f913dc4457292e079ba	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1100/5833 (18.9%); all four pericyte markers: 226/5833 (3.9%); Acta2/Tagln/Myh11: 5723/5833 (98.1%); Cnn1/Entpd1: 1915/5833 (32.8%); Plp1/Cnp: 8/5833 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 8/5833 (0.1%); Pecam1/Cdh5: 0/5833 (0.0%); Ptprc plus a listed subtype marker: 0/5833 (0.0%)	SS: n=90; detection/mean Acta2 100.0%/138, Tagln 96.7%/91.7, Myh11 96.7%/22.5, Cnn1 57.8%/4.15, Entpd1 31.1%/0.807; pericyte pair 21.1%, contractile triple 94.4%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=5732; detection/mean Acta2 100.0%/158, Tagln 99.8%/116, Myh11 98.3%/20.1, Cnn1 48.3%/2.45, Entpd1 52.4%/1.07; pericyte pair 18.8%, contractile triple 98.2%, Schwann pair 0.1%, fibroblast pair 0.1% | D7: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/102, Tagln 71.4%/50.3, Myh11 100.0%/15, Cnn1 57.1%/4.57, Entpd1 14.3%/0.685; pericyte pair 28.6%, contractile triple 71.4%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=4 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/102, Tagln 100.0%/48.1, Myh11 75.0%/15.2, Cnn1 25.0%/1.88, Entpd1 25.0%/0.469; pericyte pair 50.0%, contractile triple 75.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2523; median mitochondrial fraction 0.0672; predicted doublets 11/5833; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_025, cluster=4; source annotation_evidence/markers_resolution_025/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.711636+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
5	resolution_025	5	432	Schwann	Schwann	supported	Plp1: 96.8% detected, mean 23 versus rest 0.0544; Cnp: 88.9% detected, mean 13.4 versus rest 0.106	Other programs remain visible: same-cell pericyte pair and contractile triple 1.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 13.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e6f997da9513413875ba350696d03eb9becd30a955298bb06266857351585789	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 14/432 (3.2%); all four pericyte markers: 3/432 (0.7%); Acta2/Tagln/Myh11: 64/432 (14.8%); Cnn1/Entpd1: 10/432 (2.3%); Plp1/Cnp: 378/432 (87.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/432 (0.0%); Pecam1/Cdh5: 0/432 (0.0%); Ptprc plus a listed subtype marker: 0/432 (0.0%)	SS: n=121; detection/mean Plp1 95.0%/22, Cnp 90.1%/18.5; pericyte pair 1.7%, contractile triple 9.1%, Schwann pair 86.8%, fibroblast pair 0.0% | D3: n=215; detection/mean Plp1 97.7%/20.1, Cnp 87.0%/8.13; pericyte pair 5.6%, contractile triple 24.7%, Schwann pair 86.5%, fibroblast pair 0.0% | D7: n=35; detection/mean Plp1 94.3%/31.6, Cnp 85.7%/15.4; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 82.9%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1888; median mitochondrial fraction 0.0288; predicted doublets 4/432; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_025, cluster=5; source annotation_evidence/markers_resolution_025/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.730717+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
6	resolution_025	6	1634	pericyte	pericyte	supported	Kcnj8: 92.6% detected, mean 23.7 versus rest 3.95; Abcc9: 96.6% detected, mean 21.1 versus rest 1.9; Colec11: 92.7% detected, mean 20.4 versus rest 4.19; Vtn: 92.3% detected, mean 17.6 versus rest 4.56	Other programs remain visible: same-cell pericyte pair and contractile triple 22.5%; pericyte and fibroblast pairs 1.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e54f8c10ca88c7d748dbc62a185b045160ef415a72010445e8446786ac20fce3	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1602/1634 (98.0%); all four pericyte markers: 1347/1634 (82.4%); Acta2/Tagln/Myh11: 377/1634 (23.1%); Cnn1/Entpd1: 0/1634 (0.0%); Plp1/Cnp: 2/1634 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 16/1634 (1.0%); Pecam1/Cdh5: 0/1634 (0.0%); Ptprc plus a listed subtype marker: 0/1634 (0.0%)	SS: n=22; detection/mean Kcnj8 86.4%/20.3, Abcc9 90.9%/14.2, Colec11 90.9%/17.8, Vtn 86.4%/21.8; pericyte pair 95.5%, contractile triple 13.6%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1612; detection/mean Kcnj8 92.7%/23.8, Abcc9 96.7%/21.2, Colec11 92.7%/20.4, Vtn 92.4%/17.5; pericyte pair 98.1%, contractile triple 23.2%, Schwann pair 0.1%, fibroblast pair 1.0% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 1746; median mitochondrial fraction 0.0442; predicted doublets 0/1634; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_025, cluster=6; source annotation_evidence/markers_resolution_025/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.741115+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
0	resolution_10	0	537	VSMC	unassigned	uncertain	Acta2: 99.3% detected, mean 104 versus rest 114; Tagln: 96.5% detected, mean 58.4 versus rest 74; Myh11: 90.1% detected, mean 13.2 versus rest 15.3; Cnn1: 8.2% detected, mean 0.316 versus rest 2.23; Entpd1: 15.8% detected, mean 0.48 versus rest 0.659	Other programs remain visible: same-cell pericyte pair and contractile triple 28.5%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Separate review retains VSMC as a plausible proposal but leaves the final identity unassigned. The dominant contractile conjunction (87.5%) coexists with substantial partial pericyte-marker evidence (35.9% at least two markers), while Cnn1/Entpd1 context is limited (1.3% conjoint detection). The group is almost exclusively SS (525/537), with only 7/4/1 cells in D3/D7/D42. These observations leave the precise mural boundary unresolved with this dictionary. This is not an Acta2 or Cnn1 exclusion rule and does not establish pericyte identity. Preserve all cells in composition denominators; do not include the uncertain group in supported-pericyte contrasts.	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	f90f762dbad0a40a9915cc0d7cc85afecee926feaa4732447b722fcedeee225c	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 193/537 (35.9%); all four pericyte markers: 15/537 (2.8%); Acta2/Tagln/Myh11: 470/537 (87.5%); Cnn1/Entpd1: 7/537 (1.3%); Plp1/Cnp: 1/537 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/537 (0.0%); Pecam1/Cdh5: 0/537 (0.0%); Ptprc plus a listed subtype marker: 0/537 (0.0%)	SS: n=525; detection/mean Acta2 99.2%/104, Tagln 96.6%/58.2, Myh11 90.1%/13.2, Cnn1 8.4%/0.323, Entpd1 16.2%/0.491; pericyte pair 36.0%, contractile triple 87.6%, Schwann pair 0.2%, fibroblast pair 0.0% | D3: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/147, Tagln 100.0%/90.1, Myh11 85.7%/9.02, Cnn1 0.0%/0, Entpd1 0.0%/0; pericyte pair 28.6%, contractile triple 85.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=4 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/77.1, Tagln 75.0%/28.6, Myh11 100.0%/13.7, Cnn1 0.0%/0, Entpd1 0.0%/0; pericyte pair 50.0%, contractile triple 75.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/163, Tagln 100.0%/38.9, Myh11 100.0%/15.6, Cnn1 0.0%/0, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1555; median mitochondrial fraction 0.0422; predicted doublets 0/537; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=0; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.760559+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	additional_boundary_uncertainty
1	resolution_10	1	603	pericyte	unassigned	uncertain	Kcnj8: 42.1% detected, mean 2.15 versus rest 5.97; Abcc9: 56.6% detected, mean 2.57 versus rest 3.78; Colec11: 60.4% detected, mean 3.82 versus rest 5.81; Vtn: 81.3% detected, mean 4.47 versus rest 5.85	Other programs remain visible: same-cell pericyte pair and contractile triple 62.4%; pericyte and fibroblast pairs 0.3%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	The pericyte program is plausible but weaker or more heterogeneous than in the clear supported clusters, while a strong VSMC-like contractile program remains. No exclusive marker resolves this boundary. This is not an Acta2/Cspg4 exclusion rule: multiple-marker strength, same-cell concordance, library variation and the unresolved mixture alternative jointly limit confidence. Retain a proposed pericyte interpretation but leave final identity unassigned for quantitative outputs pending separate review. 603 cells, mostly D3: pericyte two-marker concordance is 73.3%, all-four concordance 22.2%, and contractile-triple detection 88.4%. Kcnj8 mean is 2.2 versus Myh11 9.1 normalized counts. These are plausible pericytes with a strong contractile program, but the reduced concordance and overlap leave the identity boundary uncertain; this is not classified as a confirmed VSMC group either.	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	36bd0e0ea99ca9e52dcea2aea8cc3d951a537473072ecf4d5d9fc25865eed239	SCP002-A001	accepted_versioned_annotation_decision	U	at least two of Kcnj8/Abcc9/Colec11/Vtn: 442/603 (73.3%); all four pericyte markers: 134/603 (22.2%); Acta2/Tagln/Myh11: 533/603 (88.4%); Cnn1/Entpd1: 18/603 (3.0%); Plp1/Cnp: 0/603 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 3/603 (0.5%); Pecam1/Cdh5: 0/603 (0.0%); Ptprc plus a listed subtype marker: 0/603 (0.0%)	SS: n=6 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 83.3%/9.37, Abcc9 83.3%/9.8, Colec11 66.7%/12, Vtn 100.0%/13; pericyte pair 100.0%, contractile triple 33.3%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=594; detection/mean Kcnj8 41.8%/2.09, Abcc9 56.2%/2.48, Colec11 60.4%/3.74, Vtn 81.1%/4.4; pericyte pair 73.1%, contractile triple 88.9%, Schwann pair 0.0%, fibroblast pair 0.5% | D7: n=3 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 33.3%/0.47, Abcc9 66.7%/5.27, Colec11 33.3%/3.2, Vtn 66.7%/2.54; pericyte pair 66.7%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 2317; median mitochondrial fraction 0.0455; predicted doublets 0/603; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=1; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.775646+00:00	uncertain	The pericyte program is plausible but weaker or more heterogeneous than in the clear supported clusters, while a strong VSMC-like contractile program remains. No exclusive marker resolves this boundary. This is not an Acta2/Cspg4 exclusion rule: multiple-marker strength, same-cell concordance, library variation and the unresolved mixture alternative jointly limit confidence. Retain a proposed pericyte interpretation but leave final identity unassigned for quantitative outputs pending separate review. 603 cells, mostly D3: pericyte two-marker concordance is 73.3%, all-four concordance 22.2%, and contractile-triple detection 88.4%. Kcnj8 mean is 2.2 versus Myh11 9.1 normalized counts. These are plausible pericytes with a strong contractile program, but the reduced concordance and overlap leave the identity boundary uncertain; this is not classified as a confirmed VSMC group either.	proposal_uncertainty_retained
2	resolution_10	2	185	VSMC	VSMC	supported	Acta2: 98.9% detected, mean 118 versus rest 114; Tagln: 99.5% detected, mean 77.5 versus rest 73.5; Myh11: 94.1% detected, mean 15.6 versus rest 15.3; Cnn1: 35.1% detected, mean 1.47 versus rest 2.18; Entpd1: 33.0% detected, mean 0.604 versus rest 0.654	Other programs remain visible: same-cell pericyte pair and contractile triple 23.8%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	1142f998315eb7d3ef26fbab6b59cfa98d856a744371be05e63fa7033876fada	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 50/185 (27.0%); all four pericyte markers: 5/185 (2.7%); Acta2/Tagln/Myh11: 174/185 (94.1%); Cnn1/Entpd1: 32/185 (17.3%); Plp1/Cnp: 0/185 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/185 (0.0%); Pecam1/Cdh5: 0/185 (0.0%); Ptprc plus a listed subtype marker: 0/185 (0.0%)	SS: n=29; detection/mean Acta2 100.0%/107, Tagln 100.0%/66.8, Myh11 93.1%/16.3, Cnn1 31.0%/1.62, Entpd1 20.7%/0.514; pericyte pair 20.7%, contractile triple 93.1%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=103; detection/mean Acta2 100.0%/125, Tagln 100.0%/95.1, Myh11 99.0%/16.7, Cnn1 40.8%/1.5, Entpd1 50.5%/0.803; pericyte pair 31.1%, contractile triple 99.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=16 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 93.8%/98.2, Tagln 93.8%/37.6, Myh11 87.5%/10.5, Cnn1 31.2%/1.71, Entpd1 0.0%/0; pericyte pair 6.2%, contractile triple 87.5%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=37; detection/mean Acta2 97.3%/114, Tagln 100.0%/54.3, Myh11 83.8%/14.3, Cnn1 24.3%/1.14, Entpd1 8.1%/0.38; pericyte pair 29.7%, contractile triple 83.8%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2087; median mitochondrial fraction 0.051; predicted doublets 0/185; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=2; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.795157+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
3	resolution_10	3	1276	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 131 versus rest 112; Tagln: 99.9% detected, mean 96.4 versus rest 71.7; Myh11: 99.4% detected, mean 16.5 versus rest 15.2; Cnn1: 41.4% detected, mean 1.35 versus rest 2.24; Entpd1: 49.8% detected, mean 1.03 versus rest 0.623	Other programs remain visible: same-cell pericyte pair and contractile triple 12.4%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	84f991221ec2e776357a7202b7b5d46c87f59e8f091ee8c80e572b31d058f894	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 159/1276 (12.5%); all four pericyte markers: 8/1276 (0.6%); Acta2/Tagln/Myh11: 1267/1276 (99.3%); Cnn1/Entpd1: 316/1276 (24.8%); Plp1/Cnp: 0/1276 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/1276 (0.1%); Pecam1/Cdh5: 0/1276 (0.0%); Ptprc plus a listed subtype marker: 0/1276 (0.0%)	SS: n=8 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/122, Tagln 100.0%/72.5, Myh11 100.0%/19.7, Cnn1 50.0%/1.8, Entpd1 12.5%/0.164; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1268; detection/mean Acta2 100.0%/131, Tagln 99.9%/96.6, Myh11 99.4%/16.4, Cnn1 41.3%/1.35, Entpd1 50.0%/1.04; pericyte pair 12.5%, contractile triple 99.3%, Schwann pair 0.0%, fibroblast pair 0.1% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2444; median mitochondrial fraction 0.0613; predicted doublets 0/1276; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=3; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.805701+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
4	resolution_10	4	782	pericyte	unassigned	uncertain	Kcnj8: 37.6% detected, mean 5.98 versus rest 5.83; Abcc9: 34.9% detected, mean 3.14 versus rest 3.77; Colec11: 56.3% detected, mean 8.05 versus rest 5.63; Vtn: 60.0% detected, mean 7.13 versus rest 5.74	Other programs remain visible: same-cell pericyte pair and contractile triple 28.5%; pericyte and fibroblast pairs 0.1%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	The pericyte program is plausible but weaker or more heterogeneous than in the clear supported clusters, while a strong VSMC-like contractile program remains. No exclusive marker resolves this boundary. This is not an Acta2/Cspg4 exclusion rule: multiple-marker strength, same-cell concordance, library variation and the unresolved mixture alternative jointly limit confidence. Retain a proposed pericyte interpretation but leave final identity unassigned for quantitative outputs pending separate review. Pericyte two-marker concordance varies from 31.4% in SS (35 cells) to 70.4% in D3 (54), 61.7% in D7 (209), and 56.4% in D42 (484). The contractile triple occurs in 62.1% overall, with different library patterns. Low median detected genes (1232.5) can cause dropout, and broad heterogeneity can also contribute; neither explanation is established. Identity remains uncertain.	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	40431d6272b8cc3147153e735833a906307e7f1c9392c3d9101e37ed10f7cc48	SCP002-A001	accepted_versioned_annotation_decision	U	at least two of Kcnj8/Abcc9/Colec11/Vtn: 451/782 (57.7%); all four pericyte markers: 116/782 (14.8%); Acta2/Tagln/Myh11: 486/782 (62.1%); Cnn1/Entpd1: 6/782 (0.8%); Plp1/Cnp: 2/782 (0.3%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/782 (0.1%); Pecam1/Cdh5: 0/782 (0.0%); Ptprc plus a listed subtype marker: 0/782 (0.0%)	SS: n=35; detection/mean Kcnj8 20.0%/2.53, Abcc9 17.1%/2.92, Colec11 25.7%/5.04, Vtn 48.6%/6.37; pericyte pair 31.4%, contractile triple 60.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=54; detection/mean Kcnj8 57.4%/20.9, Abcc9 46.3%/10.7, Colec11 61.1%/16.9, Vtn 57.4%/16.3; pericyte pair 70.4%, contractile triple 16.7%, Schwann pair 0.0%, fibroblast pair 1.9% | D7: n=209; detection/mean Kcnj8 40.2%/4.53, Abcc9 34.4%/2.36, Colec11 59.8%/8.04, Vtn 68.9%/7.73; pericyte pair 61.7%, contractile triple 58.4%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=484; detection/mean Kcnj8 35.5%/5.2, Abcc9 35.1%/2.65, Colec11 56.4%/7.27, Vtn 57.2%/5.9; pericyte pair 56.4%, contractile triple 69.0%, Schwann pair 0.4%, fibroblast pair 0.0%	median detected genes 1232.5; median mitochondrial fraction 0.0384; predicted doublets 8/782; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=4; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.825006+00:00	uncertain	The pericyte program is plausible but weaker or more heterogeneous than in the clear supported clusters, while a strong VSMC-like contractile program remains. No exclusive marker resolves this boundary. This is not an Acta2/Cspg4 exclusion rule: multiple-marker strength, same-cell concordance, library variation and the unresolved mixture alternative jointly limit confidence. Retain a proposed pericyte interpretation but leave final identity unassigned for quantitative outputs pending separate review. Pericyte two-marker concordance varies from 31.4% in SS (35 cells) to 70.4% in D3 (54), 61.7% in D7 (209), and 56.4% in D42 (484). The contractile triple occurs in 62.1% overall, with different library patterns. Low median detected genes (1232.5) can cause dropout, and broad heterogeneity can also contribute; neither explanation is established. Identity remains uncertain.	proposal_uncertainty_retained
5	resolution_10	5	1073	pericyte	pericyte	supported	Kcnj8: 96.7% detected, mean 38.2 versus rest 3.67; Abcc9: 91.5% detected, mean 14.7 versus rest 3.01; Colec11: 95.8% detected, mean 26.4 versus rest 4.36; Vtn: 95.2% detected, mean 30.5 versus rest 4.15	Other programs remain visible: same-cell pericyte pair and contractile triple 4.8%; pericyte and fibroblast pairs 0.4%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	12f3306586c0d52886e3db7f15b95cc7056a75830905d29c944d8a04bf6fa5cf	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1065/1073 (99.3%); all four pericyte markers: 900/1073 (83.9%); Acta2/Tagln/Myh11: 53/1073 (4.9%); Cnn1/Entpd1: 0/1073 (0.0%); Plp1/Cnp: 1/1073 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 5/1073 (0.5%); Pecam1/Cdh5: 0/1073 (0.0%); Ptprc plus a listed subtype marker: 0/1073 (0.0%)	SS: n=338; detection/mean Kcnj8 94.4%/28.4, Abcc9 88.8%/13, Colec11 96.4%/22.9, Vtn 96.2%/27.9; pericyte pair 99.7%, contractile triple 11.8%, Schwann pair 0.0%, fibroblast pair 0.3% | D3: n=17 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/27, Abcc9 94.1%/21.4, Colec11 94.1%/17.8, Vtn 100.0%/18.4; pericyte pair 100.0%, contractile triple 11.8%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=202; detection/mean Kcnj8 97.0%/42.6, Abcc9 91.1%/14.2, Colec11 96.5%/30.9, Vtn 94.6%/36.9; pericyte pair 99.0%, contractile triple 1.5%, Schwann pair 0.0%, fibroblast pair 1.0% | D42: n=516; detection/mean Kcnj8 98.1%/43.2, Abcc9 93.4%/15.7, Colec11 95.2%/27.3, Vtn 94.8%/30.1; pericyte pair 99.0%, contractile triple 1.6%, Schwann pair 0.2%, fibroblast pair 0.4%	median detected genes 1257; median mitochondrial fraction 0.031; predicted doublets 1/1073; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=5; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.844358+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
6	resolution_10	6	720	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 239 versus rest 108; Tagln: 99.9% detected, mean 159 versus rest 69.7; Myh11: 99.0% detected, mean 33.2 versus rest 14.5; Cnn1: 91.1% detected, mean 8.67 versus rest 1.89; Entpd1: 46.0% detected, mean 1.17 versus rest 0.631	Other programs remain visible: same-cell pericyte pair and contractile triple 3.2%; pericyte and fibroblast pairs 0.3%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	03b712380fe8e577643c74c025bf4da9f666f1ddd2ca49d2147b5398474143b4	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 24/720 (3.3%); all four pericyte markers: 3/720 (0.4%); Acta2/Tagln/Myh11: 713/720 (99.0%); Cnn1/Entpd1: 312/720 (43.3%); Plp1/Cnp: 1/720 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 7/720 (1.0%); Pecam1/Cdh5: 0/720 (0.0%); Ptprc plus a listed subtype marker: 0/720 (0.0%)	SS: n=401; detection/mean Acta2 100.0%/219, Tagln 100.0%/148, Myh11 99.0%/32, Cnn1 87.5%/8.2, Entpd1 41.4%/1.13; pericyte pair 2.2%, contractile triple 99.0%, Schwann pair 0.2%, fibroblast pair 1.2% | D3: n=106; detection/mean Acta2 100.0%/293, Tagln 100.0%/236, Myh11 100.0%/35.8, Cnn1 96.2%/7.72, Entpd1 73.6%/1.31; pericyte pair 7.5%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.9% | D7: n=87; detection/mean Acta2 98.9%/234, Tagln 98.9%/141, Myh11 97.7%/35.3, Cnn1 95.4%/11.3, Entpd1 31.0%/0.909; pericyte pair 3.4%, contractile triple 97.7%, Schwann pair 0.0%, fibroblast pair 1.1% | D42: n=126; detection/mean Acta2 100.0%/263, Tagln 100.0%/145, Myh11 99.2%/33.2, Cnn1 95.2%/9.15, Entpd1 47.6%/1.36; pericyte pair 3.2%, contractile triple 99.2%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2043.5; median mitochondrial fraction 0.0824; predicted doublets 1/720; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=6; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.863935+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
7	resolution_10	7	2005	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 155 versus rest 108; Tagln: 99.9% detected, mean 95.5 versus rest 70.6; Myh11: 99.2% detected, mean 23.3 versus rest 14.2; Cnn1: 54.9% detected, mean 3.78 versus rest 1.96; Entpd1: 30.4% detected, mean 0.818 versus rest 0.631	Other programs remain visible: same-cell pericyte pair and contractile triple 3.3%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	30397ec9e4cd524691aeb4815cf6f80c077afe9fce0bcd1d5e3bac1fc6e6c356	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 69/2005 (3.4%); all four pericyte markers: 2/2005 (0.1%); Acta2/Tagln/Myh11: 1986/2005 (99.1%); Cnn1/Entpd1: 390/2005 (19.5%); Plp1/Cnp: 1/2005 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2005 (0.0%); Pecam1/Cdh5: 0/2005 (0.0%); Ptprc plus a listed subtype marker: 0/2005 (0.0%)	SS: n=1974; detection/mean Acta2 99.9%/155, Tagln 99.9%/95.6, Myh11 99.3%/23.3, Cnn1 55.2%/3.78, Entpd1 30.3%/0.801; pericyte pair 3.3%, contractile triple 99.1%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=26; detection/mean Acta2 100.0%/157, Tagln 100.0%/100, Myh11 92.3%/25.5, Cnn1 34.6%/3.72, Entpd1 38.5%/1.99; pericyte pair 11.5%, contractile triple 92.3%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=4 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/69.2, Tagln 100.0%/61.2, Myh11 100.0%/37.1, Cnn1 50.0%/3.01, Entpd1 25.0%/0.785; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/120, Tagln 100.0%/19.5, Myh11 100.0%/38.9, Cnn1 0.0%/0, Entpd1 100.0%/2.78; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1826; median mitochondrial fraction 0.062; predicted doublets 6/2005; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=7; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.883559+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
8	resolution_10	8	432	Schwann	Schwann	supported	Plp1: 96.8% detected, mean 23 versus rest 0.0544; Cnp: 88.9% detected, mean 13.4 versus rest 0.106	Other programs remain visible: same-cell pericyte pair and contractile triple 1.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 13.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e6f997da9513413875ba350696d03eb9becd30a955298bb06266857351585789	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 14/432 (3.2%); all four pericyte markers: 3/432 (0.7%); Acta2/Tagln/Myh11: 64/432 (14.8%); Cnn1/Entpd1: 10/432 (2.3%); Plp1/Cnp: 378/432 (87.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/432 (0.0%); Pecam1/Cdh5: 0/432 (0.0%); Ptprc plus a listed subtype marker: 0/432 (0.0%)	SS: n=121; detection/mean Plp1 95.0%/22, Cnp 90.1%/18.5; pericyte pair 1.7%, contractile triple 9.1%, Schwann pair 86.8%, fibroblast pair 0.0% | D3: n=215; detection/mean Plp1 97.7%/20.1, Cnp 87.0%/8.13; pericyte pair 5.6%, contractile triple 24.7%, Schwann pair 86.5%, fibroblast pair 0.0% | D7: n=35; detection/mean Plp1 94.3%/31.6, Cnp 85.7%/15.4; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 82.9%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1888; median mitochondrial fraction 0.0288; predicted doublets 4/432; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=8; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.902622+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
9	resolution_10	9	934	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 265 versus rest 105; Tagln: 100.0% detected, mean 204 versus rest 66; Myh11: 100.0% detected, mean 31.8 versus rest 14.3; Cnn1: 98.6% detected, mean 7.2 versus rest 1.88; Entpd1: 74.5% detected, mean 1.39 versus rest 0.611	Other programs remain visible: same-cell pericyte pair and contractile triple 5.2%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.3%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	4e88fe4ba5bd8ef89c79ff843ec413b3d3ea4344c6443240ae738f4e8ff12714	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 49/934 (5.2%); all four pericyte markers: 7/934 (0.7%); Acta2/Tagln/Myh11: 934/934 (100.0%); Cnn1/Entpd1: 690/934 (73.9%); Plp1/Cnp: 3/934 (0.3%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/934 (0.1%); Pecam1/Cdh5: 0/934 (0.0%); Ptprc plus a listed subtype marker: 0/934 (0.0%)	SS: n=23; detection/mean Acta2 100.0%/192, Tagln 100.0%/139, Myh11 100.0%/34.2, Cnn1 100.0%/9.94, Entpd1 47.8%/1.45; pericyte pair 4.3%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=911; detection/mean Acta2 100.0%/266, Tagln 100.0%/205, Myh11 100.0%/31.7, Cnn1 98.6%/7.13, Entpd1 75.2%/1.39; pericyte pair 5.3%, contractile triple 100.0%, Schwann pair 0.3%, fibroblast pair 0.1% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 3109; median mitochondrial fraction 0.0829; predicted doublets 0/934; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=9; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.913269+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
10	resolution_10	10	2023	VSMC	VSMC	supported	Acta2: 99.5% detected, mean 142 versus rest 110; Tagln: 99.1% detected, mean 70.7 versus rest 73.9; Myh11: 95.6% detected, mean 21.5 versus rest 14.4; Cnn1: 44.0% detected, mean 3.05 versus rest 2.06; Entpd1: 24.3% detected, mean 0.808 versus rest 0.633	Other programs remain visible: same-cell pericyte pair and contractile triple 6.4%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	c217575ba91f1827cf381acd3381121348b6dea6c629d096aafcbb3335979538	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 148/2023 (7.3%); all four pericyte markers: 4/2023 (0.2%); Acta2/Tagln/Myh11: 1928/2023 (95.3%); Cnn1/Entpd1: 288/2023 (14.2%); Plp1/Cnp: 1/2023 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2023 (0.0%); Pecam1/Cdh5: 0/2023 (0.0%); Ptprc plus a listed subtype marker: 0/2023 (0.0%)	SS: n=18 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/141, Tagln 94.4%/69.9, Myh11 88.9%/17.8, Cnn1 22.2%/0.861, Entpd1 11.1%/0.319; pericyte pair 5.6%, contractile triple 83.3%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=6 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/173, Tagln 100.0%/114, Myh11 50.0%/11.3, Cnn1 0.0%/0, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 50.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=808; detection/mean Acta2 99.0%/124, Tagln 98.1%/58, Myh11 93.7%/19.1, Cnn1 35.3%/2.55, Entpd1 20.2%/0.738; pericyte pair 8.5%, contractile triple 93.3%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1191; detection/mean Acta2 99.8%/154, Tagln 99.7%/79.1, Myh11 97.1%/23.2, Cnn1 50.5%/3.44, Entpd1 27.4%/0.867; pericyte pair 6.5%, contractile triple 97.1%, Schwann pair 0.1%, fibroblast pair 0.0%	median detected genes 1499; median mitochondrial fraction 0.0645; predicted doublets 1/2023; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=10; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.932858+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
11	resolution_10	11	406	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 136 versus rest 113; Tagln: 99.8% detected, mean 69.4 versus rest 73.6; Myh11: 98.8% detected, mean 21.8 versus rest 15.1; Cnn1: 59.4% detected, mean 3.72 versus rest 2.14; Entpd1: 27.6% detected, mean 0.87 versus rest 0.648	Other programs remain visible: same-cell pericyte pair and contractile triple 4.4%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	8b8639c6c7e06a43be7a63dc868eaf8708643e398fb88df8bea468512bd53c8a	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 19/406 (4.7%); all four pericyte markers: 3/406 (0.7%); Acta2/Tagln/Myh11: 400/406 (98.5%); Cnn1/Entpd1: 70/406 (17.2%); Plp1/Cnp: 0/406 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/406 (0.0%); Pecam1/Cdh5: 0/406 (0.0%); Ptprc plus a listed subtype marker: 0/406 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=3 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/152, Tagln 100.0%/127, Myh11 100.0%/37.7, Cnn1 0.0%/0, Entpd1 66.7%/2.31; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=392; detection/mean Acta2 100.0%/135, Tagln 99.7%/68.3, Myh11 98.7%/21.6, Cnn1 59.4%/3.73, Entpd1 27.3%/0.866; pericyte pair 4.8%, contractile triple 98.5%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=11 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/174, Tagln 100.0%/93.8, Myh11 100.0%/26.9, Cnn1 72.7%/4.32, Entpd1 27.3%/0.606; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1474.5; median mitochondrial fraction 0.0768; predicted doublets 1/406; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=11; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.947981+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
12	resolution_10	12	570	pericyte	pericyte	supported	Kcnj8: 75.4% detected, mean 5.22 versus rest 5.86; Abcc9: 84.7% detected, mean 4.99 versus rest 3.7; Colec11: 69.5% detected, mean 4.8 versus rest 5.77; Vtn: 84.7% detected, mean 5.07 versus rest 5.83	Other programs remain visible: same-cell pericyte pair and contractile triple 59.6%; pericyte and fibroblast pairs 11.4%; Schwann pair and contractile triple 0.5%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	d63ec2f29d0165a54255c91de983e833b36d11f5f49be6e2411e8e16117e72e3	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 499/570 (87.5%); all four pericyte markers: 322/570 (56.5%); Acta2/Tagln/Myh11: 379/570 (66.5%); Cnn1/Entpd1: 17/570 (3.0%); Plp1/Cnp: 5/570 (0.9%); at least two of Pdgfra/Lum/Dcn/Cd34: 68/570 (11.9%); Pecam1/Cdh5: 0/570 (0.0%); Ptprc plus a listed subtype marker: 0/570 (0.0%)	SS: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 42.9%/8.69, Abcc9 57.1%/3.71, Colec11 57.1%/8.6, Vtn 100.0%/19.5; pericyte pair 57.1%, contractile triple 42.9%, Schwann pair 0.0%, fibroblast pair 14.3% | D3: n=523; detection/mean Kcnj8 76.5%/5.14, Abcc9 87.2%/5.19, Colec11 70.2%/4.76, Vtn 85.7%/4.68; pericyte pair 88.7%, contractile triple 67.7%, Schwann pair 0.8%, fibroblast pair 12.2% | D7: n=33; detection/mean Kcnj8 69.7%/5.45, Abcc9 57.6%/1.88, Colec11 60.6%/4.09, Vtn 66.7%/5.9; pericyte pair 75.8%, contractile triple 60.6%, Schwann pair 3.0%, fibroblast pair 9.1% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 57.1%/6.25, Abcc9 57.1%/5.64, Colec11 71.4%/7.34, Vtn 85.7%/15.6; pericyte pair 85.7%, contractile triple 28.6%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 4393.5; median mitochondrial fraction 0.0357; predicted doublets 0/570; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=12; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.967365+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
13	resolution_10	13	1674	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 137 versus rest 111; Tagln: 99.9% detected, mean 99.2 versus rest 70.7; Myh11: 98.5% detected, mean 18.2 versus rest 14.9; Cnn1: 41.2% detected, mean 1.61 versus rest 2.23; Entpd1: 50.0% detected, mean 1.07 versus rest 0.608	Other programs remain visible: same-cell pericyte pair and contractile triple 14.2%; pericyte and fibroblast pairs 0.1%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	6c05f4e6b0c09500dd21d5b04a3cc42b4b98b2bd2419c0aace015c1f4a77e788	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 248/1674 (14.8%); all four pericyte markers: 22/1674 (1.3%); Acta2/Tagln/Myh11: 1648/1674 (98.4%); Cnn1/Entpd1: 453/1674 (27.1%); Plp1/Cnp: 3/1674 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/1674 (0.1%); Pecam1/Cdh5: 0/1674 (0.0%); Ptprc plus a listed subtype marker: 0/1674 (0.0%)	SS: n=4 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/122, Tagln 100.0%/57.9, Myh11 100.0%/20, Cnn1 25.0%/1.52, Entpd1 50.0%/1.04; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1670; detection/mean Acta2 100.0%/137, Tagln 99.9%/99.3, Myh11 98.5%/18.2, Cnn1 41.2%/1.61, Entpd1 50.0%/1.07; pericyte pair 14.9%, contractile triple 98.4%, Schwann pair 0.2%, fibroblast pair 0.1% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2435; median mitochondrial fraction 0.0641; predicted doublets 0/1674; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=13; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.977892+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
14	resolution_10	14	1096	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 159 versus rest 111; Tagln: 98.9% detected, mean 108 versus rest 71.2; Myh11: 97.4% detected, mean 21.6 versus rest 14.8; Cnn1: 39.2% detected, mean 1.77 versus rest 2.2; Entpd1: 47.8% detected, mean 1.14 versus rest 0.62	Other programs remain visible: same-cell pericyte pair and contractile triple 11.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	87bb0f7b6f8125136e8442dae121c6f10a40ef48b1affb348c32d975c1ed0cd3	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 134/1096 (12.2%); all four pericyte markers: 7/1096 (0.6%); Acta2/Tagln/Myh11: 1063/1096 (97.0%); Cnn1/Entpd1: 286/1096 (26.1%); Plp1/Cnp: 1/1096 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/1096 (0.0%); Pecam1/Cdh5: 0/1096 (0.0%); Ptprc plus a listed subtype marker: 0/1096 (0.0%)	SS: n=17 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/120, Tagln 88.2%/63.4, Myh11 94.1%/18.8, Cnn1 17.6%/0.955, Entpd1 11.8%/0.345; pericyte pair 0.0%, contractile triple 88.2%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1077; detection/mean Acta2 99.9%/160, Tagln 99.3%/109, Myh11 97.5%/21.6, Cnn1 39.6%/1.78, Entpd1 48.5%/1.15; pericyte pair 12.3%, contractile triple 97.3%, Schwann pair 0.1%, fibroblast pair 0.0% | D7: n=2 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/38.4, Tagln 0.0%/0, Myh11 100.0%/10.2, Cnn1 0.0%/0, Entpd1 0.0%/0; pericyte pair 50.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 2249.5; median mitochondrial fraction 0.0772; predicted doublets 0/1096; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=14; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:34:59.992929+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
15	resolution_10	15	1561	pericyte	pericyte	supported	Kcnj8: 93.0% detected, mean 24.1 versus rest 4; Abcc9: 96.9% detected, mean 21.6 versus rest 1.95; Colec11: 93.0% detected, mean 20.7 versus rest 4.24; Vtn: 92.4% detected, mean 17.7 versus rest 4.6	Other programs remain visible: same-cell pericyte pair and contractile triple 22.5%; pericyte and fibroblast pairs 1.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	b1c82ad30a60a2017e1038cc452abf620869bd7209fe02618e691b19e93c8547	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1533/1561 (98.2%); all four pericyte markers: 1294/1561 (82.9%); Acta2/Tagln/Myh11: 360/1561 (23.1%); Cnn1/Entpd1: 0/1561 (0.0%); Plp1/Cnp: 2/1561 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 15/1561 (1.0%); Pecam1/Cdh5: 0/1561 (0.0%); Ptprc plus a listed subtype marker: 0/1561 (0.0%)	SS: n=13 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 92.3%/23.4, Abcc9 100.0%/16.2, Colec11 92.3%/20.8, Vtn 84.6%/18.3; pericyte pair 100.0%, contractile triple 23.1%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1548; detection/mean Kcnj8 93.0%/24.1, Abcc9 96.9%/21.6, Colec11 93.0%/20.7, Vtn 92.4%/17.7; pericyte pair 98.2%, contractile triple 23.1%, Schwann pair 0.1%, fibroblast pair 1.0% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 1746; median mitochondrial fraction 0.0444; predicted doublets 0/1561; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=15; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.003326+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
16	resolution_10	16	873	pericyte	pericyte	supported	Kcnj8: 75.1% detected, mean 10.2 versus rest 5.6; Abcc9: 70.1% detected, mean 4.64 versus rest 3.69; Colec11: 94.4% detected, mean 24.6 versus rest 4.72; Vtn: 90.1% detected, mean 20.3 versus rest 5.02	Other programs remain visible: same-cell pericyte pair and contractile triple 38.3%; pericyte and fibroblast pairs 7.8%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	5e8666adcdbbe010e52611aa26b41b92d7e739283c430d5ac85ff6d0ef3903eb	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 830/873 (95.1%); all four pericyte markers: 476/873 (54.5%); Acta2/Tagln/Myh11: 356/873 (40.8%); Cnn1/Entpd1: 8/873 (0.9%); Plp1/Cnp: 2/873 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 87/873 (10.0%); Pecam1/Cdh5: 0/873 (0.0%); Ptprc plus a listed subtype marker: 0/873 (0.0%)	SS: n=64; detection/mean Kcnj8 68.8%/6.8, Abcc9 51.6%/2.19, Colec11 93.8%/24.6, Vtn 85.9%/29.4; pericyte pair 92.2%, contractile triple 67.2%, Schwann pair 0.0%, fibroblast pair 10.9% | D3: n=79; detection/mean Kcnj8 59.5%/2.91, Abcc9 82.3%/4.05, Colec11 92.4%/14, Vtn 93.7%/18.8; pericyte pair 94.9%, contractile triple 82.3%, Schwann pair 1.3%, fibroblast pair 17.7% | D7: n=512; detection/mean Kcnj8 78.9%/11.8, Abcc9 76.0%/5.45, Colec11 94.9%/23.9, Vtn 88.5%/15; pericyte pair 95.5%, contractile triple 30.3%, Schwann pair 0.2%, fibroblast pair 10.5% | D42: n=218; detection/mean Kcnj8 73.9%/9.95, Abcc9 57.3%/3.69, Colec11 94.0%/30.1, Vtn 94.0%/30.7; pericyte pair 95.0%, contractile triple 42.7%, Schwann pair 0.0%, fibroblast pair 5.5%	median detected genes 1938; median mitochondrial fraction 0.0309; predicted doublets 3/873; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=16; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.022726+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
17	resolution_10	17	103	unassigned	unassigned	mixed	Kcnj8: 98.1% detected, mean 7.69 versus rest 5.83; Abcc9: 99.0% detected, mean 6.94 versus rest 3.72; Colec11: 95.1% detected, mean 6.29 versus rest 5.74; Vtn: 93.2% detected, mean 5.16 versus rest 5.8; Myh11: 100.0% detected, mean 18.1 versus rest 15.2; Cnn1: 70.9% detected, mean 2.58 versus rest 2.17; Entpd1: 62.1% detected, mean 0.981 versus rest 0.651; Pdgfra: 0.0% detected, mean 0 versus rest 0.0151; Lum: 1.9% detected, mean 0.0191 versus rest 0.438; Dcn: 10.7% detected, mean 0.0914 versus rest 1.62; Cd34: 3.9% detected, mean 0.0327 versus rest 0.0755	Other programs remain visible: same-cell pericyte pair and contractile triple 99.0%; pericyte and fibroblast pairs 1.9%; Schwann pair and contractile triple 1.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Strong pericyte and VSMC-associated programs occur in the same cells: all four pericyte markers commonly coincide with Acta2/Tagln/Myh11, and Cnn1/Entpd1 coexpression is substantial. Elevated doublet flags and complexity add concern, but do not prove doublets. Pericyte contractile overlap alone would not justify exclusion; the combined unusually strong dual signature leaves mural identity unresolved. Retain all cells in composition denominators, label unassigned, and exclude this cluster from supported-pericyte contrasts. 103 cells: 93 express all four pericyte markers; all 103 express Acta2/Tagln/Myh11; 51 express Cnn1/Entpd1. Eleven Scrublet flags are retained. The joint signature is not evidence that cells convert between mural lineages.	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	16d6921e598982422ad2ef61867e39a1bae1bc2c828e951d351f35d4bc58a579	SCP002-A001	accepted_versioned_annotation_decision	M	at least two of Kcnj8/Abcc9/Colec11/Vtn: 102/103 (99.0%); all four pericyte markers: 93/103 (90.3%); Acta2/Tagln/Myh11: 103/103 (100.0%); Cnn1/Entpd1: 51/103 (49.5%); Plp1/Cnp: 1/103 (1.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 2/103 (1.9%); Pecam1/Cdh5: 0/103 (0.0%); Ptprc plus a listed subtype marker: 0/103 (0.0%)	SS: n=11 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/10.3, Abcc9 100.0%/6.47, Colec11 100.0%/8.04, Vtn 100.0%/7.96, Myh11 100.0%/18.9, Cnn1 72.7%/2.55, Entpd1 45.5%/0.812, Pdgfra 0.0%/0, Lum 0.0%/0, Dcn 0.0%/0, Cd34 0.0%/0; pericyte pair 100.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=90; detection/mean Kcnj8 97.8%/6.79, Abcc9 98.9%/6.99, Colec11 94.4%/5.67, Vtn 92.2%/4.59, Myh11 100.0%/18.2, Cnn1 72.2%/2.64, Entpd1 65.6%/1.02, Pdgfra 0.0%/0, Lum 2.2%/0.0218, Dcn 12.2%/0.105, Cd34 3.3%/0.0226; pericyte pair 98.9%, contractile triple 100.0%, Schwann pair 1.1%, fibroblast pair 2.2% | D7: n=2 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 100.0%/34.2, Abcc9 100.0%/7.04, Colec11 100.0%/24.5, Vtn 100.0%/15.6, Myh11 100.0%/6.62, Cnn1 0.0%/0, Entpd1 0.0%/0, Pdgfra 0.0%/0, Lum 0.0%/0, Dcn 0.0%/0, Cd34 50.0%/0.666; pericyte pair 100.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 3640; median mitochondrial fraction 0.0668; predicted doublets 11/103; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=17; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.038574+00:00	mixed	Strong pericyte and VSMC-associated programs occur in the same cells: all four pericyte markers commonly coincide with Acta2/Tagln/Myh11, and Cnn1/Entpd1 coexpression is substantial. Elevated doublet flags and complexity add concern, but do not prove doublets. Pericyte contractile overlap alone would not justify exclusion; the combined unusually strong dual signature leaves mural identity unresolved. Retain all cells in composition denominators, label unassigned, and exclude this cluster from supported-pericyte contrasts. 103 cells: 93 express all four pericyte markers; all 103 express Acta2/Tagln/Myh11; 51 express Cnn1/Entpd1. Eleven Scrublet flags are retained. The joint signature is not evidence that cells convert between mural lineages.	proposal_uncertainty_retained
18	resolution_10	18	254	fibroblast	fibroblast	supported	Pdgfra: 58.3% detected, mean 0.853 versus rest 0.00242; Lum: 96.1% detected, mean 25.5 versus rest 0.0569; Dcn: 99.6% detected, mean 70.6 versus rest 0.57; Cd34: 81.9% detected, mean 3.39 versus rest 0.0252	Other programs remain visible: same-cell pericyte pair and contractile triple 2.4%; pericyte and fibroblast pairs 7.5%; Schwann pair and contractile triple 1.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	ad76ec777d98dba2bdb0ed0396bb20c6950d0a93d54d154a7e2d55fdf0b304f3	SCP002-A001	accepted_versioned_annotation_decision	F	at least two of Kcnj8/Abcc9/Colec11/Vtn: 19/254 (7.5%); all four pericyte markers: 4/254 (1.6%); Acta2/Tagln/Myh11: 47/254 (18.5%); Cnn1/Entpd1: 3/254 (1.2%); Plp1/Cnp: 3/254 (1.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 253/254 (99.6%); Pecam1/Cdh5: 0/254 (0.0%); Ptprc plus a listed subtype marker: 0/254 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=82; detection/mean Pdgfra 76.8%/0.923, Lum 92.7%/6.54, Dcn 98.8%/21, Cd34 74.4%/1.32; pericyte pair 14.6%, contractile triple 43.9%, Schwann pair 1.2%, fibroblast pair 98.8% | D7: n=165; detection/mean Pdgfra 49.1%/0.772, Lum 97.6%/33.2, Dcn 100.0%/89.4, Cd34 85.5%/4.31; pericyte pair 4.2%, contractile triple 6.7%, Schwann pair 1.2%, fibroblast pair 100.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Pdgfra 57.1%/1.96, Lum 100.0%/66.5, Dcn 100.0%/206, Cd34 85.7%/6.26; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 100.0%	median detected genes 3424.5; median mitochondrial fraction 0.0239; predicted doublets 0/254; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=resolution_10, cluster=18; source annotation_evidence/markers_resolution_10/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.053492+00:00	supported	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	supported_broad_identity_retained
0	structure_seed_1702	0	2615	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 149 versus rest 107; Tagln: 99.7% detected, mean 91.4 versus rest 70.3; Myh11: 98.0% detected, mean 21.9 versus rest 14.1; Cnn1: 48.1% detected, mean 3.28 versus rest 1.97; Entpd1: 29.1% detected, mean 0.792 versus rest 0.628	Other programs remain visible: same-cell pericyte pair and contractile triple 7.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	7d339ed81e1b0945054b74beca2339292da61784a562efa6e5bd27a9a2fd945f	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 219/2615 (8.4%); all four pericyte markers: 10/2615 (0.4%); Acta2/Tagln/Myh11: 2555/2615 (97.7%); Cnn1/Entpd1: 455/2615 (17.4%); Plp1/Cnp: 3/2615 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/2615 (0.0%); Pecam1/Cdh5: 0/2615 (0.0%); Ptprc plus a listed subtype marker: 0/2615 (0.0%)	SS: n=2565; detection/mean Acta2 99.9%/149, Tagln 99.7%/91.1, Myh11 98.1%/21.8, Cnn1 48.3%/3.28, Entpd1 29.0%/0.784; pericyte pair 8.4%, contractile triple 97.9%, Schwann pair 0.1%, fibroblast pair 0.0% | D3: n=42; detection/mean Acta2 100.0%/177, Tagln 100.0%/120, Myh11 88.1%/25.6, Cnn1 42.9%/3.79, Entpd1 33.3%/1.34; pericyte pair 7.1%, contractile triple 88.1%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=6 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/69, Tagln 100.0%/49.1, Myh11 100.0%/36.8, Cnn1 33.3%/2.01, Entpd1 16.7%/0.523; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=2 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/141, Tagln 100.0%/29.2, Myh11 100.0%/27.2, Cnn1 0.0%/0, Entpd1 50.0%/1.39; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 1803; median mitochondrial fraction 0.0587; predicted doublets 7/2615; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=structure_seed_1702, cluster=0; source annotation_evidence/markers_structure_seed_1702/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.073200+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
1	structure_seed_1702	1	1907	VSMC	VSMC	supported	Acta2: 97.1% detected, mean 114 versus rest 114; Tagln: 94.8% detected, mean 54.9 versus rest 75.9; Myh11: 87.8% detected, mean 16 versus rest 15.2; Cnn1: 19.8% detected, mean 1.23 versus rest 2.29; Entpd1: 15.9% detected, mean 0.562 versus rest 0.665	Other programs remain visible: same-cell pericyte pair and contractile triple 17.4%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	9bed4bdfe485f9e7393145eb3edbe8c14acc7ac60421ce4e3f01903089c45ce2	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 481/1907 (25.2%); all four pericyte markers: 78/1907 (4.1%); Acta2/Tagln/Myh11: 1632/1907 (85.6%); Cnn1/Entpd1: 107/1907 (5.6%); Plp1/Cnp: 2/1907 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/1907 (0.0%); Pecam1/Cdh5: 0/1907 (0.0%); Ptprc plus a listed subtype marker: 0/1907 (0.0%)	SS: n=135; detection/mean Acta2 98.5%/147, Tagln 94.8%/82.9, Myh11 89.6%/22.4, Cnn1 37.0%/2.18, Entpd1 13.3%/0.478; pericyte pair 6.7%, contractile triple 86.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=13 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/124, Tagln 92.3%/89.5, Myh11 53.8%/22.3, Cnn1 30.8%/3.47, Entpd1 7.7%/0.326; pericyte pair 7.7%, contractile triple 53.8%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=585; detection/mean Acta2 93.7%/92.7, Tagln 90.6%/41.6, Myh11 83.2%/12.2, Cnn1 10.8%/0.703, Entpd1 13.3%/0.498; pericyte pair 30.8%, contractile triple 80.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=1174; detection/mean Acta2 98.6%/121, Tagln 96.9%/57.9, Myh11 90.3%/17.1, Cnn1 22.1%/1.36, Entpd1 17.5%/0.606; pericyte pair 24.8%, contractile triple 88.6%, Schwann pair 0.2%, fibroblast pair 0.0%	median detected genes 1392; median mitochondrial fraction 0.0507; predicted doublets 6/1907; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=structure_seed_1702, cluster=1; source annotation_evidence/markers_structure_seed_1702/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.092775+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
2	structure_seed_1702	2	2781	VSMC	VSMC	supported	Acta2: 100.0% detected, mean 158 versus rest 105; Tagln: 100.0% detected, mean 115 versus rest 65.5; Myh11: 99.7% detected, mean 20.3 versus rest 14.3; Cnn1: 57.4% detected, mean 2.41 versus rest 2.13; Entpd1: 57.4% detected, mean 1.17 versus rest 0.552	Other programs remain visible: same-cell pericyte pair and contractile triple 7.3%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	3e9aa0bef52f1e2fee2b0ec5835cc0c10d8cab722d90f2a20c6b7e8c1092ea49	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 204/2781 (7.3%); all four pericyte markers: 10/2781 (0.4%); Acta2/Tagln/Myh11: 2774/2781 (99.7%); Cnn1/Entpd1: 1059/2781 (38.1%); Plp1/Cnp: 1/2781 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/2781 (0.0%); Pecam1/Cdh5: 0/2781 (0.0%); Ptprc plus a listed subtype marker: 0/2781 (0.0%)	SS: n=19 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/135, Tagln 100.0%/84.1, Myh11 100.0%/24.4, Cnn1 68.4%/4.34, Entpd1 42.1%/0.942; pericyte pair 5.3%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=2762; detection/mean Acta2 100.0%/158, Tagln 100.0%/115, Myh11 99.7%/20.3, Cnn1 57.3%/2.4, Entpd1 57.5%/1.18; pericyte pair 7.3%, contractile triple 99.7%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 2566; median mitochondrial fraction 0.0703; predicted doublets 0/2781; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=structure_seed_1702, cluster=2; source annotation_evidence/markers_structure_seed_1702/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.103377+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
3	structure_seed_1702	3	1361	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 154 versus rest 110; Tagln: 99.6% detected, mean 80.2 versus rest 72.9; Myh11: 98.8% detected, mean 25 versus rest 14.4; Cnn1: 65.5% detected, mean 4.69 versus rest 1.96; Entpd1: 29.1% detected, mean 0.915 versus rest 0.631	Other programs remain visible: same-cell pericyte pair and contractile triple 2.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	7abd66737e7ebeb73981880c3b3f4fbf8c305be633ac18347dade8628d7c6eb5	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 37/1361 (2.7%); all four pericyte markers: 4/1361 (0.3%); Acta2/Tagln/Myh11: 1342/1361 (98.6%); Cnn1/Entpd1: 286/1361 (21.0%); Plp1/Cnp: 1/1361 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/1361 (0.0%); Pecam1/Cdh5: 0/1361 (0.0%); Ptprc plus a listed subtype marker: 0/1361 (0.0%)	SS: n=9 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/136, Tagln 100.0%/86.1, Myh11 88.9%/18, Cnn1 44.4%/3.87, Entpd1 33.3%/0.91; pericyte pair 0.0%, contractile triple 88.9%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=3 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/234, Tagln 100.0%/138, Myh11 100.0%/30.8, Cnn1 0.0%/0, Entpd1 33.3%/1.51; pericyte pair 0.0%, contractile triple 100.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D7: n=844; detection/mean Acta2 99.9%/139, Tagln 99.4%/69.4, Myh11 98.2%/23.2, Cnn1 57.6%/4.1, Entpd1 25.8%/0.86; pericyte pair 3.2%, contractile triple 98.0%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=505; detection/mean Acta2 99.8%/179, Tagln 99.8%/97.9, Myh11 99.8%/28.1, Cnn1 79.6%/5.72, Entpd1 34.5%/1; pericyte pair 2.0%, contractile triple 99.8%, Schwann pair 0.2%, fibroblast pair 0.0%	median detected genes 1561; median mitochondrial fraction 0.0758; predicted doublets 1/1361; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=structure_seed_1702, cluster=3; source annotation_evidence/markers_structure_seed_1702/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.122934+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
4	structure_seed_1702	4	1190	pericyte	pericyte	supported	Kcnj8: 93.4% detected, mean 35.3 versus rest 3.63; Abcc9: 86.0% detected, mean 13.7 versus rest 2.99; Colec11: 92.9% detected, mean 24.7 versus rest 4.32; Vtn: 92.1% detected, mean 28 versus rest 4.14	Other programs remain visible: same-cell pericyte pair and contractile triple 7.1%; pericyte and fibroblast pairs 0.3%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	83de9b6873b5f6e15027d372d14628d5542bb8e1ee39d70e538fe40753c148b9	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1160/1190 (97.5%); all four pericyte markers: 892/1190 (75.0%); Acta2/Tagln/Myh11: 86/1190 (7.2%); Cnn1/Entpd1: 0/1190 (0.0%); Plp1/Cnp: 1/1190 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 5/1190 (0.4%); Pecam1/Cdh5: 0/1190 (0.0%); Ptprc plus a listed subtype marker: 0/1190 (0.0%)	SS: n=387; detection/mean Kcnj8 91.2%/25.5, Abcc9 83.7%/11.8, Colec11 93.8%/20.9, Vtn 93.5%/25.4; pericyte pair 98.4%, contractile triple 16.3%, Schwann pair 0.0%, fibroblast pair 0.3% | D3: n=55; detection/mean Kcnj8 76.4%/25.9, Abcc9 58.2%/14, Colec11 74.5%/19.5, Vtn 74.5%/19.4; pericyte pair 87.3%, contractile triple 9.1%, Schwann pair 0.0%, fibroblast pair 1.8% | D7: n=176; detection/mean Kcnj8 94.3%/41, Abcc9 85.2%/14, Colec11 96.0%/29.7, Vtn 90.9%/34.9; pericyte pair 97.7%, contractile triple 1.7%, Schwann pair 0.0%, fibroblast pair 1.1% | D42: n=572; detection/mean Kcnj8 96.3%/41.1, Abcc9 90.4%/14.9, Colec11 93.0%/26.3, Vtn 93.2%/28.5; pericyte pair 97.7%, contractile triple 2.6%, Schwann pair 0.2%, fibroblast pair 0.2%	median detected genes 1210; median mitochondrial fraction 0.0309; predicted doublets 4/1190; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=structure_seed_1702, cluster=4; source annotation_evidence/markers_structure_seed_1702/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.142387+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
5	structure_seed_1702	5	432	Schwann	Schwann	supported	Plp1: 96.8% detected, mean 23 versus rest 0.0544; Cnp: 88.9% detected, mean 13.4 versus rest 0.106	Other programs remain visible: same-cell pericyte pair and contractile triple 1.6%; pericyte and fibroblast pairs 0.0%; Schwann pair and contractile triple 13.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	e6f997da9513413875ba350696d03eb9becd30a955298bb06266857351585789	SCP002-A001	accepted_versioned_annotation_decision	S	at least two of Kcnj8/Abcc9/Colec11/Vtn: 14/432 (3.2%); all four pericyte markers: 3/432 (0.7%); Acta2/Tagln/Myh11: 64/432 (14.8%); Cnn1/Entpd1: 10/432 (2.3%); Plp1/Cnp: 378/432 (87.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 0/432 (0.0%); Pecam1/Cdh5: 0/432 (0.0%); Ptprc plus a listed subtype marker: 0/432 (0.0%)	SS: n=121; detection/mean Plp1 95.0%/22, Cnp 90.1%/18.5; pericyte pair 1.7%, contractile triple 9.1%, Schwann pair 86.8%, fibroblast pair 0.0% | D3: n=215; detection/mean Plp1 97.7%/20.1, Cnp 87.0%/8.13; pericyte pair 5.6%, contractile triple 24.7%, Schwann pair 86.5%, fibroblast pair 0.0% | D7: n=35; detection/mean Plp1 94.3%/31.6, Cnp 85.7%/15.4; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 82.9%, fibroblast pair 0.0% | D42: n=61; detection/mean Plp1 98.4%/30.4, Cnp 95.1%/20.9; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 95.1%, fibroblast pair 0.0%	median detected genes 1888; median mitochondrial fraction 0.0288; predicted doublets 4/432; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=structure_seed_1702, cluster=5; source annotation_evidence/markers_structure_seed_1702/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.161454+00:00	supported	Concordant Plp1 and Cnp are widespread and strongly enriched relative to the other clusters, including in each adequately populated library. Mcam/Cspg4 and scattered contractile transcripts do not establish mural identity; the frozen dictionary uses these as non-exclusive context. Broad Schwann-like identity is supported, without claiming lineage proof or excluding low-level contamination. 	supported_broad_identity_retained
6	structure_seed_1702	6	965	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 277 versus rest 104; Tagln: 99.9% detected, mean 209 versus rest 65.4; Myh11: 99.5% detected, mean 34.7 versus rest 14.1; Cnn1: 98.5% detected, mean 9.29 versus rest 1.75; Entpd1: 63.7% detected, mean 1.29 versus rest 0.615	Other programs remain visible: same-cell pericyte pair and contractile triple 5.0%; pericyte and fibroblast pairs 0.2%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	75e695301fa2d9766d8423816e13a181c2715ebd35781d2df47ce93f17e89cf9	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 50/965 (5.2%); all four pericyte markers: 6/965 (0.6%); Acta2/Tagln/Myh11: 960/965 (99.5%); Cnn1/Entpd1: 614/965 (63.6%); Plp1/Cnp: 2/965 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 8/965 (0.8%); Pecam1/Cdh5: 0/965 (0.0%); Ptprc plus a listed subtype marker: 0/965 (0.0%)	SS: n=220; detection/mean Acta2 100.0%/239, Tagln 100.0%/173, Myh11 98.6%/35.3, Cnn1 97.3%/10.8, Entpd1 42.7%/1.1; pericyte pair 2.7%, contractile triple 98.6%, Schwann pair 0.0%, fibroblast pair 2.3% | D3: n=591; detection/mean Acta2 100.0%/297, Tagln 100.0%/237, Myh11 100.0%/34.8, Cnn1 99.5%/8.43, Entpd1 76.8%/1.38; pericyte pair 6.4%, contractile triple 100.0%, Schwann pair 0.3%, fibroblast pair 0.3% | D7: n=58; detection/mean Acta2 98.3%/246, Tagln 98.3%/145, Myh11 98.3%/34.4, Cnn1 94.8%/11.2, Entpd1 27.6%/0.777; pericyte pair 1.7%, contractile triple 98.3%, Schwann pair 0.0%, fibroblast pair 1.7% | D42: n=96; detection/mean Acta2 100.0%/262, Tagln 100.0%/151, Myh11 99.0%/33.2, Cnn1 97.9%/9.86, Entpd1 53.1%/1.44; pericyte pair 5.2%, contractile triple 99.0%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2869; median mitochondrial fraction 0.0823; predicted doublets 0/965; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=structure_seed_1702, cluster=6; source annotation_evidence/markers_structure_seed_1702/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.180961+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
7	structure_seed_1702	7	1521	pericyte	pericyte	supported	Kcnj8: 76.2% detected, mean 9.03 versus rest 5.53; Abcc9: 77.3% detected, mean 4.91 versus rest 3.63; Colec11: 85.3% detected, mean 16.9 versus rest 4.65; Vtn: 88.4% detected, mean 14.6 versus rest 4.94	Other programs remain visible: same-cell pericyte pair and contractile triple 46.8%; pericyte and fibroblast pairs 8.8%; Schwann pair and contractile triple 0.3%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	06d0ccfb527b8ad593d99d620374585fd69be9d570d9d1ba6afbffb0976519d9	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1409/1521 (92.6%); all four pericyte markers: 867/1521 (57.0%); Acta2/Tagln/Myh11: 776/1521 (51.0%); Cnn1/Entpd1: 27/1521 (1.8%); Plp1/Cnp: 7/1521 (0.5%); at least two of Pdgfra/Lum/Dcn/Cd34: 157/1521 (10.3%); Pecam1/Cdh5: 0/1521 (0.0%); Ptprc plus a listed subtype marker: 0/1521 (0.0%)	SS: n=70; detection/mean Kcnj8 67.1%/7.09, Abcc9 52.9%/2.37, Colec11 91.4%/23.4, Vtn 87.1%/28.7; pericyte pair 90.0%, contractile triple 65.7%, Schwann pair 0.0%, fibroblast pair 11.4% | D3: n=634; detection/mean Kcnj8 74.3%/4.62, Abcc9 87.1%/4.9, Colec11 74.0%/5.76, Vtn 87.1%/6.29; pericyte pair 89.9%, contractile triple 71.6%, Schwann pair 0.8%, fibroblast pair 12.1% | D7: n=593; detection/mean Kcnj8 79.9%/13.4, Abcc9 76.6%/5.64, Colec11 92.9%/23.1, Vtn 87.9%/15.9; pericyte pair 94.6%, contractile triple 30.4%, Schwann pair 0.3%, fibroblast pair 9.9% | D42: n=224; detection/mean Kcnj8 74.6%/10.5, Abcc9 58.9%/3.81, Colec11 95.5%/30.2, Vtn 93.7%/30.5; pericyte pair 96.0%, contractile triple 42.9%, Schwann pair 0.0%, fibroblast pair 5.8%	median detected genes 2396; median mitochondrial fraction 0.033; predicted doublets 3/1521; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=structure_seed_1702, cluster=7; source annotation_evidence/markers_structure_seed_1702/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.200282+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
8	structure_seed_1702	8	168	VSMC	VSMC	supported	Acta2: 97.6% detected, mean 113 versus rest 114; Tagln: 97.6% detected, mean 78.9 versus rest 73.5; Myh11: 92.9% detected, mean 15 versus rest 15.3; Cnn1: 35.1% detected, mean 1.5 versus rest 2.18; Entpd1: 38.7% detected, mean 0.628 versus rest 0.654	Other programs remain visible: same-cell pericyte pair and contractile triple 28.6%; pericyte and fibroblast pairs 0.6%; Schwann pair and contractile triple 0.0%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	93227c0d676ea5d878330fd85752b1ac968a925142dbc794abe1eee4001ed079	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 57/168 (33.9%); all four pericyte markers: 14/168 (8.3%); Acta2/Tagln/Myh11: 155/168 (92.3%); Cnn1/Entpd1: 31/168 (18.5%); Plp1/Cnp: 0/168 (0.0%); at least two of Pdgfra/Lum/Dcn/Cd34: 1/168 (0.6%); Pecam1/Cdh5: 0/168 (0.0%); Ptprc plus a listed subtype marker: 0/168 (0.0%)	SS: n=28; detection/mean Acta2 100.0%/108, Tagln 100.0%/65.5, Myh11 92.9%/16.2, Cnn1 32.1%/1.68, Entpd1 21.4%/0.533; pericyte pair 21.4%, contractile triple 92.9%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=110; detection/mean Acta2 100.0%/120, Tagln 99.1%/92.7, Myh11 100.0%/15.9, Cnn1 37.3%/1.43, Entpd1 52.7%/0.806; pericyte pair 37.3%, contractile triple 99.1%, Schwann pair 0.0%, fibroblast pair 0.9% | D7: n=11 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/115, Tagln 100.0%/47.8, Myh11 90.9%/12.5, Cnn1 36.4%/2.08, Entpd1 0.0%/0; pericyte pair 0.0%, contractile triple 90.9%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: n=19 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 78.9%/80.1, Tagln 84.2%/36.7, Myh11 52.6%/9.41, Cnn1 26.3%/1.31, Entpd1 5.3%/0.0987; pericyte pair 52.6%, contractile triple 52.6%, Schwann pair 0.0%, fibroblast pair 0.0%	median detected genes 2572.5; median mitochondrial fraction 0.05; predicted doublets 0/168; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=structure_seed_1702, cluster=8; source annotation_evidence/markers_structure_seed_1702/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.219921+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
9	structure_seed_1702	9	2310	VSMC	VSMC	supported	Acta2: 99.9% detected, mean 123 versus rest 112; Tagln: 98.9% detected, mean 85.7 versus rest 71.6; Myh11: 95.3% detected, mean 16.1 versus rest 15.1; Cnn1: 24.6% detected, mean 0.993 versus rest 2.36; Entpd1: 39.6% detected, mean 0.867 versus rest 0.62	Other programs remain visible: same-cell pericyte pair and contractile triple 32.6%; pericyte and fibroblast pairs 0.2%; Schwann pair and contractile triple 0.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	a1b5c17da00b7777e5f3fbf43db620e2b9975dbb50aaeec42d8b0821f3833960	SCP002-A001	accepted_versioned_annotation_decision	V	at least two of Kcnj8/Abcc9/Colec11/Vtn: 824/2310 (35.7%); all four pericyte markers: 209/2310 (9.0%); Acta2/Tagln/Myh11: 2193/2310 (94.9%); Cnn1/Entpd1: 365/2310 (15.8%); Plp1/Cnp: 5/2310 (0.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 5/2310 (0.2%); Pecam1/Cdh5: 0/2310 (0.0%); Ptprc plus a listed subtype marker: 0/2310 (0.0%)	SS: n=26; detection/mean Acta2 100.0%/87.2, Tagln 80.8%/53.7, Myh11 84.6%/13.3, Cnn1 34.6%/1.31, Entpd1 19.2%/0.343; pericyte pair 65.4%, contractile triple 76.9%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=2281; detection/mean Acta2 99.9%/123, Tagln 99.2%/86.2, Myh11 95.4%/16.1, Cnn1 24.5%/0.991, Entpd1 39.9%/0.872; pericyte pair 35.3%, contractile triple 95.2%, Schwann pair 0.2%, fibroblast pair 0.2% | D7: n=3 (fewer than 20 cells; descriptive support is fragile); detection/mean Acta2 100.0%/30.4, Tagln 33.3%/4.8, Myh11 100.0%/11.6, Cnn1 0.0%/0, Entpd1 33.3%/1.6; pericyte pair 66.7%, contractile triple 33.3%, Schwann pair 0.0%, fibroblast pair 0.0% | D42: 0 cells; marker fractions undefined	median detected genes 2249.5; median mitochondrial fraction 0.0584; predicted doublets 11/2310; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=structure_seed_1702, cluster=9; source annotation_evidence/markers_structure_seed_1702/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.234997+00:00	supported	A dominant concordant Acta2/Tagln/Myh11 program, with Cnn1/Entpd1 evidence considered alongside the much weaker or less widespread pericyte dictionary, supports a broad VSMC-like identity. Shared mural markers alone were not decisive. Minority pericyte-program cells and lower-count library subsets remain possible heterogeneity, true overlap, ambient RNA or doublets; the cluster label is not a purity guarantee. No arterial/venous subtype is assigned. 	supported_broad_identity_retained
10	structure_seed_1702	10	1605	pericyte	pericyte	supported	Kcnj8: 92.5% detected, mean 23.8 versus rest 3.98; Abcc9: 96.8% detected, mean 21.2 versus rest 1.93; Colec11: 92.5% detected, mean 20.5 versus rest 4.21; Vtn: 92.4% detected, mean 17.5 versus rest 4.58	Other programs remain visible: same-cell pericyte pair and contractile triple 23.2%; pericyte and fibroblast pairs 1.0%; Schwann pair and contractile triple 0.1%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	2ef9065a888dab03e6b44fe10574c268fcd68e1922e49fdd865b92f839203e67	SCP002-A001	accepted_versioned_annotation_decision	P	at least two of Kcnj8/Abcc9/Colec11/Vtn: 1575/1605 (98.1%); all four pericyte markers: 1321/1605 (82.3%); Acta2/Tagln/Myh11: 381/1605 (23.7%); Cnn1/Entpd1: 0/1605 (0.0%); Plp1/Cnp: 2/1605 (0.1%); at least two of Pdgfra/Lum/Dcn/Cd34: 16/1605 (1.0%); Pecam1/Cdh5: 0/1605 (0.0%); Ptprc plus a listed subtype marker: 0/1605 (0.0%)	SS: n=14 (fewer than 20 cells; descriptive support is fragile); detection/mean Kcnj8 92.9%/24.8, Abcc9 100.0%/16.8, Colec11 92.9%/21.1, Vtn 85.7%/17.4; pericyte pair 100.0%, contractile triple 21.4%, Schwann pair 0.0%, fibroblast pair 0.0% | D3: n=1591; detection/mean Kcnj8 92.5%/23.7, Abcc9 96.8%/21.3, Colec11 92.5%/20.5, Vtn 92.5%/17.6; pericyte pair 98.1%, contractile triple 23.8%, Schwann pair 0.1%, fibroblast pair 1.0% | D7: 0 cells; marker fractions undefined | D42: 0 cells; marker fractions undefined	median detected genes 1752; median mitochondrial fraction 0.0444; predicted doublets 0/1605; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=structure_seed_1702, cluster=10; source annotation_evidence/markers_structure_seed_1702/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.245380+00:00	supported	Concordant Kcnj8, Abcc9, Colec11 and Vtn expression, including same-cell concordance, supports a broad pericyte identity in mural context. Contractile and partial matrix expression are compatible with the overlaps documented by Tung; neither Cspg4 absence nor Acta2 positivity is an exclusion rule. This is a broad cluster assignment, not proof that every barcode is a pericyte, not an activated-state classifier and not lineage tracing. 	supported_broad_identity_retained
11	structure_seed_1702	11	252	fibroblast	fibroblast	supported	Pdgfra: 58.3% detected, mean 0.855 versus rest 0.0025; Lum: 96.0% detected, mean 25.7 versus rest 0.0579; Dcn: 99.6% detected, mean 70.6 versus rest 0.578; Cd34: 82.1% detected, mean 3.42 versus rest 0.0252	Other programs remain visible: same-cell pericyte pair and contractile triple 2.0%; pericyte and fibroblast pairs 7.1%; Schwann pair and contractile triple 1.2%. Endothelial/immune conjunctions are explicitly recorded, not inferred absent from selection. Missing RNA can reflect dropout; positive low-level RNA can reflect ambient contamination. Expression-based doublet flags do not resolve all mixed or same-lineage doublets. Library and time are coupled, and biological-unit identities are not recovered.	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	/root/scp002_review	separate_agent_review	2026-09-12T09:46:58.297311+00:00	f53f5e6118ac9a54dbee461ed69e914c7e2b97874345efe68c3d9197668d4956	6faaaabc9678af783ebe922c2bfb80c8417fa921f16b44f1c0a9882253eaf323	SCP002-A001	accepted_versioned_annotation_decision	F	at least two of Kcnj8/Abcc9/Colec11/Vtn: 18/252 (7.1%); all four pericyte markers: 4/252 (1.6%); Acta2/Tagln/Myh11: 46/252 (18.3%); Cnn1/Entpd1: 3/252 (1.2%); Plp1/Cnp: 3/252 (1.2%); at least two of Pdgfra/Lum/Dcn/Cd34: 251/252 (99.6%); Pecam1/Cdh5: 0/252 (0.0%); Ptprc plus a listed subtype marker: 0/252 (0.0%)	SS: 0 cells; marker fractions undefined | D3: n=82; detection/mean Pdgfra 76.8%/0.923, Lum 92.7%/6.54, Dcn 98.8%/21, Cd34 74.4%/1.32; pericyte pair 14.6%, contractile triple 43.9%, Schwann pair 1.2%, fibroblast pair 98.8% | D7: n=163; detection/mean Pdgfra 49.1%/0.773, Lum 97.5%/33.5, Dcn 100.0%/89.8, Cd34 85.9%/4.35; pericyte pair 3.7%, contractile triple 6.1%, Schwann pair 1.2%, fibroblast pair 100.0% | D42: n=7 (fewer than 20 cells; descriptive support is fragile); detection/mean Pdgfra 57.1%/1.96, Lum 100.0%/66.5, Dcn 100.0%/206, Cd34 85.7%/6.26; pericyte pair 0.0%, contractile triple 0.0%, Schwann pair 0.0%, fibroblast pair 100.0%	median detected genes 3441; median mitochondrial fraction 0.0239; predicted doublets 0/252; missing calls 0	evidence/cluster_marker_summary.tsv and evidence/same_cell_program_summary.tsv, variant=structure_seed_1702, cluster=11; source annotation_evidence/markers_structure_seed_1702/	/root/annotation_evidence	separate_ai_annotation_assessor_not_final_reviewer	2026-09-12T09:35:00.260221+00:00	supported	Pdgfra with widespread Lum, Dcn and Cd34 provides concordant fibroblast evidence, not matrix expression alone. Sparse pericyte identity markers and a partial contractile program do not outweigh this four-marker pattern. Contractile overlap is not proof of myofibroblast identity or transdifferentiation. The selected cells and cluster assignment do not establish whole-heart abundance. 	supported_broad_identity_retained